@SchmitBiophys

Emergent behavior in biomolecules. I study how biomolecules interact. Not just 1 or 2 molecules, but moles of them.

 Manhattan, Kansas
Joined September 2008
  • Tweets507
  • Following403
  • Followers527
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In these days without conferences, we need to find new ways to communicate our science. I'm not going to say that I know the right or wrong way to do this. But the right way is with Lego. @Afarnti @PNASNews
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Thrilled to be a part of this collaboration!
Kresten Lindorff-Larsen@LindorffLarsen20 Feb 2024
How do proteins mis-fold? New preprint led by @JAunstrup from @alexander_buell @biophysics_dtu group with MD simulations by Abigail Barclay. We combined experimental measurements of Φ-values with restrained simulations to study the TSE for fibril growth doi.org/10.26434/chemrxiv-20…
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Congrats to the lab and collaborator @SchmitBiophys ! (more soon!) Polyubiquitin ligand-induced phase transitions are optimized by spacing between ubiquitin units | PNAS pnas.org/doi/10.1073/pnas.23…
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Circuit Topology Approach for the Comparative Analysis of Intrinsically Disordered Proteins #IDP #compchem #cheminformatics pubs.acs.org/doi/10.1021/acs… @VSheikhhasani @laurenswh @SchmitBiophys @AlirezaMashaghi Vol63 Issue8 #JCIM #Bioinformatics
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Jeremy Schmit retweeted
Pools Trader@PcclsTrader13 May 2023
Fun collaboration with @SchmitBiophys - I learnt a lot in process and our discovery opens the door for many more experiments!
The Science of Parkinson's@ScienceofPD12 May 2023
New paper from @PernillaWittung et al explores elongation kinetics of #Parkinsons-associated α-synuclein with Thioflavin-T fluorescence & solution state NMR spectroscopy, & finds elongation of synuclein amyloids involves distinct kinetic regimes cell.com/biophysj/fulltext/S…
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Interested in designing ligands to optimize phase separation of scaffolds in condensates? With @SchmitBiophys, we dived into this problem using designed tetraubiquitin ligand hubs, and combined theory and experiment to uncover molecular rules - learn more: biorxiv.org/content/10.1101/…
Phase diagrams with designed tetraUb ligand and UBQLN2

ALT Phase diagrams with designed tetraUb ligand and UBQLN2

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Jeremy Schmit retweeted
Andrea Bauerfeind@mages058 Nov 2022
Missed The @FASEBorg Nuclear Bodies Conference this year? Read the Meeting Report in the FASEB Journal doi.org/10.1096/fj.202201455…; then sign up to be notified of the next conference, bit.ly/37LRHog. #NBSRC22 #GeneControl #RNAmetabolism #PhaseSeparation #Genomics #Cancer
This FASEB Science Research Conference (SRC) is the only conference focused exclusively on nuclear bodies. This inaugural meeting will focus on the most recent developments linking the biology of nuclear bodies to cancer and other disease states. This conference aims to unite distinguished researchers as well as new investigators from different fields – such as cell biology, genomics, biophysics, and cancer biology – to foster interdisciplinary synergism, crosstalk, and future collaborations.

ALT This FASEB Science Research Conference (SRC) is the only conference focused exclusively on nuclear bodies. This inaugural meeting will focus on the most recent developments linking the biology of nuclear bodies to cancer and other disease states. This conference aims to unite distinguished researchers as well as new investigators from different fields – such as cell biology, genomics, biophysics, and cancer biology – to foster interdisciplinary synergism, crosstalk, and future collaborations.

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That submission feeling...
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Thanks to @OASaleh and Fyl Pincus for a great visit to UCSB. And to all the physics and BMSE students for their fantastic questions. It's amazing how much the place has grown since I was there!
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Afternoon fun at the Protein Folding #GRC with Ed O'Brian, @fried_lab, and @SulkowskaL. Not shown: @davethirum
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Getting an early start on #GRC Protein Folding Dynamics. Looking forward to seeing everyone in Ventura!
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Thanks so much for the opportunity to speak!
IDPseminars@IDPseminars1 Sep 2022
Replying to @IDPseminars
@SchmitBiophys showed how the network structure encode the functional properties of condensate to give unique structure/function properties. He also reminded us that about the limitations of condensates as reaction crucibles: Slow diffusion. ⬇️ doi.org/10.1101/2022.05.05.4…
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Honored and excited to present in @IDPseminars this week!
IDPseminars@IDPseminars29 Aug 2022
Join us on Thursday for seminars by @ioana_ilie_UvA and @SchmitBiophys! New attendees can register at: idpseminars.com
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Jeremy Schmit retweeted
Jie Xiao@JieXiao_Lab3 Aug 2022
Assistant professors wanted! Come to join us at Johns Hopkins School of Medicine Biophysics! apply.interfolio.com/110326
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Jeremy Schmit retweeted
IDPseminars@IDPseminars28 Jul 2022
After a brief break, we are happy to announce our program for the coming months featuring: @BoeynaemsSteven, @DrJoanShea @ioana_ilie_UvA, @SchmitBiophys, @savitski_lab, @Nicolas_Fawzi, @daviddesancho, Frans Mulder, @jrkumita and Christine Keating.
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Announcing the latest from the Schmit group: a special treat for the amyloid afficionados in the Twitterverse (I know you're out there!) A look at nucleation of the aggregates driving diseases like Alzheimer’s and Huntington’s. 1/9 doi.org/10.1016/j.bpj.2022.0…
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Our result explains co-aggregation data in length variants. Since amyloid nuclei only involve a few amino acids from each chain, they are relatively insensitive to sequence or length differences. Differences are more important during elongation. 8/9 science.org/doi/full/10.1126…

Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β40 (Aβ40) by the...

Combined experiment and simulation reveals a structural mechanism of surface-catalyzed nucleation in Aβ amyloid formation.

science.org
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Special thanks to lead author @PhanBioPhys for doing all the hard work and @HalfmannLab for helpful discussions. 9/9
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