@SchleinLab

Develop innovative AI and wet lab approaches in biomedical science | MD, PhD, MBA | Medical Geneticist https://xitter.cf/t.co/Ns5PX9MmKJ

 Hamburg, GER
Joined June 2022
  • Tweets157
  • Following197
  • Followers234
41Media
Christian Schlein retweeted
Cell Genomics@CellGenomicsAug 6
Telomere-to-telomere genome assembly and a pangenome for the rat dlvr.it/TTtzNQ

Telomere-to-telomere genome assembly and a pangenome for the rat

Rat strains have been used in a wide range of genetic studies. Here, the rat genome is advanced through the creation of a T2T assembly that provides novel insights into genome content and function....

cell.com
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Familial hypercholesterolemia was recorded in Danish registries since 1978, as the only country in the world. In both women and men in 1978 through 2021 age at death normalized but not age at coronary heart disease. Eur Heart J just published: academic.oup.com/eurheartj/a…
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Honored to have received the @AusMito travel award to represent @SchleinLab and present our work on mitochondrial fatty acid synthesis at @aussiemit 2024! Looking forward to this opportunity and meeting you all there! @TRR_BATenergy #mitochondria #lipids #brownfat
Mito Foundation@AusMito21 Nov 2024
🌟 Congrats to the recipients of the Mito Foundation's travel grants for @aussiemit 2024! These travel grants will help 7 researchers and health professionals attend AussieMit — Australia's largest conference related to mitochondrial biology and disease. aussiemit.com.au/awards/

Awards - Aussiemit 2026

There is no excerpt because this is a protected post.

aussiemit.com.au
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The @DDEA_Denmark Postdoctoral summit 2024 was a blast! Honored to receive the “Best Poster Award” and the “Second Best Poster Pitch Award” for our lab's recent collaborative work. @annawo13 @SchleinLab. Heartfelt thanks to the organizers and the committee for an incredible week!
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"Lipoprotein(a) and cardiovascular disease" review published today in The Lancet: 50 days' free access: authors.elsevier.com/a/1jlsN… Please share and resend for others to download. Bottom line: measure Lp(a) in all once in a lifetime and stay tuned for coming Lp(a)-lowering therapy!
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Christian Schlein retweeted
Alexander Bartelt@BarteltLab24 Jul 2024
Today, we report that cholesterol-induced inflammation in adipocytes is under control of the Nfe2l1-ATF3 pathway. Proteasome-mediated proteostasis is vital to suppress insulin resistance and atherosclerosis in mice and is linked to obesity in humans. 👇 biorxiv.org/content/10.1101/… – at Munich, Germany

Control of cholesterol-induced adipocyte inflammation by the Nfe2l1-Atf3 pathway

While adipocytes are critical pillars of energy metabolism, their dysfunction is linked to adipose tissue (AT) inflammation, insulin resistance, and ectopic lipotoxicity in cardiometabolic diseases....

biorxiv.org
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My first author paper from my thesis work has been uploaded to BioRxiv! We identified Mecr as important for T cell fitness in in vivo CRISPR screens. I have further worked with Mecr and am the first to show it regulates T cell function and metabolism. biorxiv.org/content/10.1101/…

Mitochondrial Fatty Acid Synthesis and Mecr Regulate CD4+ T Cell Function and Oxidative Metabolism

Summary We show that the mitochondrial fatty acid synthesis gene Mecr shapes CD4+ T cell metabolism and function. It may be targeted in inflammatory diseases and provides rationale to consider the...

biorxiv.org
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Christian Schlein retweeted
Björn Schumacher@schumacherbj23 Jun 2024
Preprints need to gain more visibility. With the current review process they are years ahead of the conventional publishing record. If you are a funding body, pay reviewers to evaluate preprints to make them fully eligible as track record.
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Christian Schlein retweeted
CNAG@cnag_eu4 Jun 2024
...and last but not least at #eshg2024: 👩‍🔬Our analyst Ida Paramonov presents the disease-causing mitochondrial variants she has worked on in @Solve_RD 🙌Great effort, many congratulations! #CNAG #RareDiseases #FindACure #Genomics #GeneticDiseases #DiagnosticOdyssey
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Christian Schlein retweeted
Sam Tsimikas, MD
@Lpa_Doc7 Apr 2024
This is a medical first- despite drug approvals for TG >500, none were shown to reduce pancreatitis. The Balance study required great science, a great drug, great study design, and great execution to succeed. Congrats to @ionispharma for 15 yrs of dedication and perseverance to help patients in need! nejm.org/doi/full/10.1056/NE…
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Christian Schlein retweeted
Aaron Cypess@acypess24 Mar 2024
Excellent summary describing both Lp(a) and what to do if high.
Family Heart Foundation
@FamilyHeartFdn24 Mar 2024
A6: “Make sure you go to a clinician who understands all of the complex ramifications of Lp(a) and is trained to deal with it.” - @DrLipid #KnowLpa
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Ever wondered what determines the composition of complex lipids? Here, Worthmann (@annawo13) et al. show that endogenous lipid synthesis controls the use of #PUFA and thus determine the therapeutic benefit of #omega3 fatty acid supplementation. @SchleinLab nature.com/articles/s41467-0…

Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use

Nature Communications - Polyunsaturated Fatty Acids (PUFA), such as omega-3 fatty acids, are recognized for their lipid lowering and anti-inflammatory properties. Here, the authors show that...

nature.com
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Christian Schlein retweeted
CRC/TRR-BATenergy@TRR_BATenergy7 Jan 2024
New publications from our TRR333 PIs @SchleinLab @annawo13 ! What a great start for the new year 2024! Huge congrats!
Christian Schlein
@SchleinLab2 Jan 2024
And now the manuscript got published at @NatureComms. What a nice start into 2024! Thanks to @annawo13 and her group as well as all other collaborateurs for this journey. #HappyNewYear @UKEHamburg nature.com/articles/s41467-0…

Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use

Nature Communications - Polyunsaturated Fatty Acids (PUFA), such as omega-3 fatty acids, are recognized for their lipid lowering and anti-inflammatory properties. Here, the authors show that...

nature.com
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Christian Schlein retweeted
Oded Rechavi
@OdedRechavi3 Nov 2023
MUST WATCH. The best description of the situation that I've seen so far, by the German vice-chancellor, Robert Habeck.
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Vice Chancellor Robert Habeck on the dimension of the terror, Germanys historical responsibility and our deep solidarity with Israel. 🇮🇱 סגן הקנצלר והשר הפדרלי רוברט האבק על ממדי מתקפות הטרור הברבריות, האחריות ההיסטורית הגרמנית והסולידריות העמוקה והבלתי מעורערת שלנו לישראל 🇮🇱
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Happy to be representing @SchleinLab at the 46th European Lipoprotein Club @society_eas and discussing our recent findings with @F_Haumann and @annawo13 in regards to the importance of mitochondrial fatty acid synthesis for metabolic health. – at Tutzing, Germany
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Christian Schlein retweeted
Nature Metabolism
@NatMetabolism27 Jul 2023
METABOLIC MESSENGER FGF21 was originally found to correct metabolic dysfunction & body weight in metabolic disease. @potthofflab & @Kyle_H_Flippo (@uiowa) discuss FGF21's discovery & current knowledge on pharmacological & physiological effects. #Tbt 🔙 nature.com/articles/s42255-0…

Metabolic Messengers: FGF21

Nature Metabolism - Flippo and Potthoff provide a concise overview of the major physiological and pharmacological effects of FGF21 in nutrient and energy homeostasis.

nature.com
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Extremely happy and proud to be among the “Rising Star Awards 2023” recipients at the #BATenegy international conference! Thanks to the organizing committee for this opportunity and for funding my research! Of course a big thanks for the continuous support from @SchleinLab! – at Hamburg, Germany
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Happy to present our data from @SchleinLab on mtFAS and its implication in brown adipose tissue function at the @TRR_BATenergy in Hamburg. #brownfat #mitochondria #lipids #BATenergy – at Hamburg, Germany
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Christian Schlein retweeted
Pablo M. Garcia-Roves@m_roves6 Apr 2023
Of interest!
Christian Schlein
@SchleinLab5 Apr 2023
Mitochondria are excellent in breaking down fatty acids. But did you know that they also can produce fatty acids? In our latest preprint, we show that mitochondrial fatty acid synthesis is an essential player in systemic energy metabolism. medrxiv.org/content/10.1101/…

Mitochondrial fatty acid synthesis is essential for coordinated energy transformation

Mitochondria warrant cellular energy demands by generating energy equivalents in central carbon metabolism. They are also able to newly synthesize fatty acids via mitochondrial fatty acid synthesis...

medrxiv.org
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