Pediatrician scientist | PGY-2 @BCM_pediatrics | MD/PhD from @UMNMSTP and @Masopust_Vezys lab | former postbac @NIH VRC | Terp alum @UofMaryland
Joined June 2019
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Sathi Wijeyesinghe retweeted
Through sex-inclusive research, we find that meningeal regulatory T cells suppress pain sensitivity under the control of ovarian hormones.
science.org/doi/10.1126/scie…
by @EloraMidavaine, at @UCSF, in @ScienceMagazine.
ALT Spinal cord meningeal sheets demonstrating Tregs (red) and nerves (blue). Note: These nerves are not the same nerves of the skin that are being tested for pain, and are not the same nerves that are injured.
#Immunology out now @ScienceMagazine
Regulatory T cells inhibit pain sensing in female, but not male, mice.
buff.ly/GU13Wsz
By @EloraMidavaine, @sakeen_k et al.
Sathi Wijeyesinghe retweeted
Our NIH grant to discover coronavirus antiviral meds was terminated today.
With this grant, we had developed a better SARSCoV2 inhibitor than Paxlovid, and we recently discovered an improved drug that looks better than Pfizer's own second-generation inhibitor.
Sathi Wijeyesinghe retweeted
Hear from a talented lineup of immunologists next Wednesday, Sept 18 featuring @zurisullivan, @alexwellsies, @DjenetBousbaine, @ValeriaMReyes, @CicaCanesso, @ScientistBecs, @Liwen_Deng811, & @NZanluqui.
Register: bit.ly/ScrippsLeaders
Sathi Wijeyesinghe retweeted
Our paper describing in vitro resident memory T cell differentiation in an epithelial organoid model is out at @CellReports doi.org/10.1016/j.celrep.202…. If you are excited about T cells and reproductive mucosa, we are looking for postdocs-apply.interfolio.com/145385
Sathi Wijeyesinghe retweeted
Excited to share our perspective on resident memory T cells in solid tumors!!Huge thanks to @ImmunityCP and @Jodi___G. Amazing figures and artwork from @KatarinaECheng and support from the whole @Masopust_Vezys team.
kwnsfk27.r.eu-west-1.awstrac…
Sathi Wijeyesinghe retweeted
Delighted to share our new work @Jamequistlab @CFI_UMN on cytokine regulation of homeostatic memory CD8 T cells
biorxiv.org/content/10.1101/…
tl;dr homeostatic circulating and resident memory CD8 T cells are resilient to loss of IL-7Rα (surprise!)
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Collaboration between IL-7 and IL-15 enables adaptation of tissue-resident and circulating memory CD8+ T cells biorxiv.org/cgi/content/shor… #biorxiv_immuno
Sathi Wijeyesinghe retweeted
We are seeking 1-2 talented immunology students to join our team in the tropical and picturesque region of North Queensland, where summers are endless and sunshine is abundant.
Sathi Wijeyesinghe retweeted
Cutting Edge: First Lung Infection Permanently Enlarges Lymph Nodes and Enhances New T Cell Responses journals.aai.org/jimmunol/ar…
Sathi Wijeyesinghe retweeted
The Thompson lab is officially live! Excited to announce that I recently accepted a faculty position @JohnsHopkinsMMI studying immunometabolic regulation of vaccine responses. Kicking off the new lab with my first purchase, obviously a @CytekBio flow cytometer!
Sathi Wijeyesinghe retweeted
Very excited to share our paper led by @madisonstrine Intestinal tuft cell immune privilege enables norovirus persistence | Science Immunology science.org/doi/10.1126/scii… 1/n
Sathi Wijeyesinghe retweeted
CD39 is expressed on functional effector and tissue resident memory CD8+ T cells biorxiv.org/cgi/content/shor… #biorxiv_immuno
Sathi Wijeyesinghe retweeted
Thrilled to announce the opening of the Srivatsan Lab (srivatsan-lab.com) at the @fredhutch. The lab will be building new sequencing technologies to understand how our cells and bodies form over the course of development.
The newest @FredHutch Basic Sciences lab opens its doors! The @SRsrivatsan Lab is developing new sequencing technologies to interrogate structure-function relationships during vertebrate development. The lab is growing and hiring at all levels: srivatsan-lab.com/
Sathi Wijeyesinghe retweeted
Michael is the godfather of viral pathogenesis and the reason so many labs have been able to use LCMV (and other viruses) for fundamental discoveries. He was an inspiration and giant in the field. I will be forever grateful to the advice he gave me early in my career. RIP MBAO
The Scripps Research community mourns the passing of Michael Oldstone, MD, esteemed virologist and professor emeritus, who helped establish the viral pathogenesis field and shaped our understanding of host immune responses scripps.edu/news-and-events/…
Sathi Wijeyesinghe retweeted
Our study on human T cell memory formation during infancy and childhood revealing progressive maturation of tissue resident subsets in mucosal sites is online—thanks to @tconnors22, @_shivaliv and great collaborators @AYatesGroup, @psimslab @bruskolab.
cell.com/immunity/fulltext/S…
Sathi Wijeyesinghe retweeted
Very excited to share our work in @SciImmunology on the migration properties of CD8+ tumor-infiltrating lymphocytes (TILs)! Using 🐭 models and parabiosis, we uncovered unique features of tumor-resident T cells. Spoiler 🚨tumor ≠ healthy tissue. science.org/doi/10.1126/scii… 1/7
Sathi Wijeyesinghe retweeted
check out our paper from my time as a postdoc in @Masopust_Vezys lab! cellular and humoral immunity working together🤝! Resident memory T cells induce rapid (within hrs) vascular permeability in the female reproductive tract, enabling infiltration of neutralizing antibodies 1/5
Work from @PCRosato1,@Masopust_Vezys, and colleagues show CD8+ TRMs may enhance local #humoral immunity. mucosalimmunology.org/articl…
Sathi Wijeyesinghe retweeted
Authored by Andrew G. Soerens et al, we show that #Tcells are capable of proliferating in response to iterative stimulation for over 10yrs! And produce enough progeny to occupy a volume 30,000x the Earth's volume! @Nature nature.com/articles/s41586-0…
Sathi Wijeyesinghe retweeted
Very excited to share our work on HIV, out this week in @Nature. We sort and RNA-seq infected cells solely based on the detection of provirus DNA. Infected CD4 T cells have unique signatures that help to explain HIV persistence in vivo. nature.com/articles/s41586-0…
