@SarlahLab

Complex Molecules. Enabling Synthesis.

 Rice University
sarlahgroup.com
Joined April 2019
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Check out our recent approach to sannamycins, featuring dearomative hydroamination of benzene, interesting skeletal reorganization, and novel use of biomass material as a carbohydrate precursor.
J. Am. Chem. Soc.@J_A_C_S21 Aug 2025
Enantioselective Total Syntheses of Sannamycins A and B | Journal of the American Chemical Society @SarlahLab @RiceChemistry @RiceUniversity @ChemistryUIUC pubs.acs.org/doi/10.1021/jac…

Enantioselective Total Syntheses of Sannamycins A and B

Abstract. Aminoglycoside antibiotics are one of the oldest and most clinically relevant classes of anti-infective agents, yet their complex molecular archi

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Stereodivergent #Synthesis of Perhydrobenz[e]indene Terpenoids by Cheng Yang, Christopher J. Huck, @YaroslavBoyko4, Shang Ning, Uroš Vezonik, Alexander S. Shved, Scott E. Denmark, Binh Khanh Mai, David Sarlah @SarlahLab at @RiceChemistry in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
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Check our synthesis of nimbolide! A streamlined approach enabled by a powerful borylative Heck reaction and a stereochemically interesting alkyl ether formation. Fun fact: two identical twins working on the same molecule...I guess they are trying to keep it in the family😅
J. Am. Chem. Soc.@J_A_C_S22 Apr 2025
Stereoselective Total Synthesis of Nimbolide | Journal of the American Chemical Society @TotalSynthesis @TotalSyntheses @SarlahLab @RiceChemistry pubs.acs.org/doi/10.1021/jac…

Stereoselective Total Synthesis of Nimbolide

Abstract. A stereoselective total synthesis of nimbolide has been achieved in a convergent, 11-step sequence from α-methyl-(R)-carvone. The strategy relied

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Come and join us at GRC Natural Products this summer! We have a fantastic line of speakers from academia and industry. Be a part of the frontiers of science related to the chemistry and biology of bioactive compounds! grc.org/natural-products-and…
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Total Syntheses of Scabrolide B, Ineleganolide, and Related Norcembranoids | Journal of the American Chemical Society @SarlahLab @UofIllinois @ChemistryUIUC @RiceUniversity @TotalSynthesis @TotalSyntheses #Scabrolide #Norcembranoids #Mukaiyama #Michael pubs.acs.org/doi/10.1021/jac…

Total Syntheses of Scabrolide B, Ineleganolide, and Related Norcembranoids

Abstract. Concise total syntheses of several 5/7/6 norcembranoids, including ineleganolide, scabrolide B, sinuscalide C, and fragilolide A have been achiev

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Check our hydroamination of arenes! Adding hydride and nitrogen functionality across arenes has never been so easy.
Angewandte Chemie@angew_chem17 Jul 2024
Copper-Catalyzed Dearomative 1,2-Hydroamination (David Sarlah and co-workers) @SarlahLab #OpenAccess onlinelibrary.wiley.com/doi/…

Copper‐Catalyzed Dearomative 1,2‐Hydroamination

Harnessing an arenophile-mediated photocycloaddition and copper hydride catalysis, we report a formal dearomative hydroamination of nonactivated feedstock arenes, including benzene and naphthalene....

onlinelibrary.wiley.com
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Now online: News & Views on the Article by Wen-Xiu Xu, Zhuo Peng, Qing-Xiu Gu, Yao Zhu, Li-Han Zhao, Fucheng Leng & Hai-Hua Lu nature.com/articles/s44160-0… ($) Hydrogenation streamlines cyclolignan synthesis by David Ryffel & David Sarlah @SarlahLab nature.com/articles/s44160-0… ($)
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Oxidative Dearomatization of Pyridines | Journal of the American Chemical Society @IGBIllinois @SarlahLab @UofIllinois @TotalSyntheses #Dearomatization #Pyridines pubs.acs.org/doi/10.1021/jac…

Oxidative Dearomatization of Pyridines

Abstract. Dearomatization of pyridines is a well-established synthetic approach to access piperidines. Although remarkably powerful, existing dearomatizati

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Great collaboration with #PfizerChemistry, showcasing translation of our dearomatization chemistry to pyridines.
Scott Bagley@BagPhos17 Jan 2024
Dearomatization of pyridines is a rapidly evolving method of making functionalized amino-hets The @SarlahLab in #ChemCollabs with #PfizerChemistry has a new oxidative method now out in @J_A_C_S doi.org/10.1021/jacs.3c13603

Oxidative Dearomatization of Pyridines

Abstract. Dearomatization of pyridines is a well-established synthetic approach to access piperidines. Although remarkably powerful, existing dearomatizati

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Congratulations to our former member @Conghui_Tang for an awesome paper!
Angewandte Chemie@angew_chem23 Nov 2023
Direct C-C Double Bond Cleavage of Alkenes Enabled by Highly Dispersed Cobalt Catalyst and Hydroxylamine (Conghui Tang and co-workers) @Conghui_Tang onlinelibrary.wiley.com/doi/…

Direct C−C Double Bond Cleavage of Alkenes Enabled by Highly Dispersed Cobalt Catalyst and Hydrox...

A mild oxidative cleavage of alkene to form oxime ether was achieved by using single-atom cobalt catalyst and hydroxylamine. Diversified substrate patterns, including internal and terminal alkenes,...

onlinelibrary.wiley.com
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David Sarlah (@SarlahLab) closing the day at #EFMCASMC23 (with homefield advantage in #Croatia): Larock cyclization strategy based atropselective synthesis of darobactin A & even more fun with unhealthy looking twisted tricyclic terpenes. Next stop: speaker‘s dinner!
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Day 3 ⁦@ACSorganic⁩ #GRS2023 Amazing student presentations: Alexander Oanta (Northwestern Univ), David Ryffel (Univ of Illinois), Jenna Humke (Univ of Minnesota), Matthew McVeigh (UCLA) ⁦@SarlahLab⁩ ⁦@GargLab⁩
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It will fit but won't flip! Check out our preliminary collaborative study with @SpiroChemAG and #MerckChemistry, evaluating (very!) rigid Dewar pyridine derivatives as programmable piperidine isosteres. ift.tt/Bn4Kape
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Total Syntheses of Scabrolide A and Yonarolide @YaroslavBoyko4 @The_Foreign_ @SarlahLab @ChemistryUIUC @UofIllinois @TotalSyntheses #Scabrolide #Yonarolide #Diterpenes #NiPpentannulation #Methylenecyclopropane #Fragmentation #LiebeskindSroglCoupling pubs.acs.org/doi/10.1021/jac…

Total Syntheses of Scabrolide A and Yonarolide

Abstract. The concise total syntheses of oxidized norcembranoid terpenoids (−)-scabrolide A and (−)-yonarolide have been accomplished in 10 and 11 steps, r

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#TotalSyntheses of Scabrolide A and Yonarolide by Roberto Serrano, Yaroslav D. Boyko @YaroslavBoyko4, Lucas W. Hernandez, Aleksandras Lotuzas @The_Foreign_, and David Sarlah @SarlahLab at @ChemistryUIUC in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
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It’s here! Check out episode 4 of this season where we talk #TotalSynthesis of Darobactin A, a project in collaboration with. @SarlahLab. Check out the show on your favorite podcast platform! Apple: podcasts.apple.com/us/podcas… Spotify: open.spotify.com/episode/5mv…
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Featured in our One year of Nature Synthesis collection nature.com/articles/s44160-0… Article by @SarlahLab @pengliu_group Synthesis of (+)-ribostamycin by catalytic, enantioselective hydroamination of benzene
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π-Extended Rubrenes via Dearomative Annulative π-Extension Reaction @NagoyaUniv @Itamilab @SarlahLab @UofIllinois @ChemistryUIUC #PiExtended #Rubrenes #Dearomative #Annulative #PiExtension pubs.acs.org/doi/10.1021/jac…

π‑Extended Rubrenes via Dearomative Annulative π‑Extension Reaction

Abstract. Among a large variety of organic semiconducting materials, rubrene (5,6,11,12-tetraphenyltetracene) represents one of the most prominent molecula

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Our last issue of the year contains this great review from David Sarlah @SarlahLab & co @ChemistryUIUC on dearomative logic in natural product total synthesis Be sure to check out the full review on our website below🔽 pubs.rsc.org/en/content/arti…
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Check the story behind our Darobactin #synthesis, hosted by @MatthewHorwitz1. #TotalSynthesis #MerckChemistry
Synthesis Workshop@MatthewHorwitz119 Nov 2022
Today on Synthesis Workshop, David Ryffel (@SarlahLab @ChemistryUIUC) joins us to share his work on the total synthesis of Darobactin A in a brand new Research Spotlight episode! Episode: youtu.be/xgNyK4cZQUc @J_A_C_S 2022, 144, 31, 14026. doi.org/10.1021/jacs.2c05891
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