The superbioactivity is based on precise segmentation of assemblies containing amino acids with positive and negative charge but lacking specific signals. We observed by live microscopy a "tapping" motion of protein-laden negative segments on neurons at millisecond time scales.

Using dipolar coupling, we observed the formation of salt bridges between lysine and glutamic acid residues, suggesting the folding of neuro-active epitopes. Coassembly of two biological signals was demonstrated, along with small clusters and filaments in the dynamic systems.

12 carbons in the hydrophobic segment generated the right cohesion and pKa of acidic amino acids to cross the barrier and reassemble. 2 or 4 additional carbons trap the assemblies in endothelial cells. Our findings should help in the design of supramolecular drugs for the brain.

The materials enhance maturation and electrophysiology in mouse and human neurons. The bioactivity is provided by supramolecular assemblies of peptide amphiphiles. The conducting polymer was PEDOT with dual functionalization by design for bonding to the printable polysaccharide.

These water-based materials will require new approaches to the characterization of ferroelectricity given their expected ionic conductivity. This generates more complex data with linear and nonlinear effects.

Interestingly, the effective supramolecular copolymerization which traps the toxic peptides requires metastable nanofibers. This significantly improved survival of motor and cortical neurons exposed to Aβ42.

The highly emissive supramolecular polymers form upon addition of sea water to amino-naphthalene imide aggregates, and the superoxide produced upon visible light irradiation generates hydrogen peroxide—a potential liquid fuel.