@SamantLab

Group Leader @BabrahamInst. He/him. All things #ubiquitin #proteostasis #proteomics #ageing #senescence. Spend too much on food & wine. Opinions mine, all mine!

 Cambridge, UK
samantlab.github.io/
Joined March 2012
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🧬 Looking for a PhD in the biosciences? Applications are open for the Cambridge Biosciences DTP, offering fully funded PhD opportunities across a range of research areas. 📅 Deadline: 8 December 2026 🔗 bbsrcdtp.lifesci.cam.ac.uk/h… #PhD #Biosciences
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Rahul Samant retweeted
ShorterLab@ShorterLab
Sep 26
VCP is a critical component for TDP-43 disaggregase activity in skeletal muscle: biorxiv.org/content/10.64898…

VCP is a critical component for TDP-43 disaggregase activity in skeletal muscle

TDP-43 aggregates are a unifying pathological feature between several neurodegenerative diseases and myopathies. Mutations in the AAA ATPase protein VCP have been linked to TDP-43 proteinopathies in...

biorxiv.org
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A Deep-Learning Based Biomarker of Systemic Cellular Senescence Burden to Predict Mortality and Health Outcomes onlinelibrary.wiley.com/doi/…

A Deep‐Learning Based Biomarker of Systemic Cellular Senescence Burden to Predict Mortality and...

Using 38 blood SASP proteins, a guided autoencoder-transformer model generates a composite SASP Score that captures systemic cellular senescence burden. The score predicts mortality and age-related...

onlinelibrary.wiley.com
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Rahul Samant retweeted
Carmen Sandi@carmensandi10
Sep 24
Meet the outstanding chairs & discussants who will help drive the conversations across the plenary panels. #GSRNet2027 #StressResearch #ResilienceResearch @GSRNet_
🤖 Made with AI
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Rahul Samant retweeted
Daniel Heller@Dan_A_Heller
Sep 24
So excited to be part of this incredible work out today in @ScienceMagazine on how P-selectin-targeted anti-senescence nanotherapy can fight fibrotic conditions and cancers. Congrats to @LoweLabMSKCC and @hellerlab members and others @MSKCancerCenter!! science.org/doi/10.1126/scie…

Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer

Fibrotic remodeling of tissues and tumors establishes immunosuppressive microenvironments that drive organ dysfunction and, in cancer, limit response to immunotherapy. Senescent-like cells are...

science.org
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Loss of killifish cGAS attenuates age-related signatures but does not affect organismal life span link.springer.com/article/10…

Loss of killifish cGAS attenuates age-related signatures but does not affect organismal life span

EMBO Reports - The cGAS/STING pathway is a central innate immune signaling pathway responsive to cytosolic DNA. Chronic activation of this pathway promotes numerous age-related pathologies, but its...

link.springer.com
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Senescent cell heterogeneity in brain aging and neurodegenerative disease: Neuron cell.com/neuron/fulltext/S08…

Senescent cell heterogeneity in brain aging and neurodegenerative disease

This review by Graves et al. synthesizes emerging evidence that senescent brain cells are heterogeneous, dynamic, and context dependent, highlighting determinants of diverse programs and emphasizing...

cell.com
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Rahul Samant retweeted
Janet Kumita@jrkumita
Sep 21
ANNOUNCING the 2nd UK Biomolecular Condensates Network Symposium (8th-10th Dec 2026)! Join us to celebrate the diversity of #condensates research. Register (QR code) & submit Abstracts: docs.google.com/forms/d/e/1F… Spaces are limited! @PhysicsofLifeUK
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Rahul Samant retweeted
Janet Kumita@jrkumita
Sep 22
Put the UK Biomolecular Condensates monthly on-line seminar into your diary (2nd Oct 2026, 1 pm BST). Jennifer McManus and Mark Ashe are presenting! @Markashe #condensates @PhysicsofLifeUK
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Clocking in at just under 4 hours, the examiners commended Devinda for her thoughtful approach during the viva, and ability to stand up (sometimes literally...) for her convictions.
Rahul Samant@SamantLab
Mar 27
Congrats to Devinda for passing her PhD viva with flying colours! Massive thanks to examiners Cleo Bishop and Angeleen Fleming for an “intense but fun” experience.
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Congrats to Devinda for passing her PhD viva with flying colours! Massive thanks to examiners Cleo Bishop and Angeleen Fleming for an “intense but fun” experience.
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Samant Lab #preprint no. 4: “Ubi-SCAPE enables deep exploration of the poly-ubiquitylome” biorxiv.org/content/10.64898… 🧵 to follow soon—but check it out in the meantime! #proteomics #TeamMassSpec
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We're #hiring a #postdoc--get in touch! Someone with expertise in 3D models (organoids/ALIs) and advanced imaging, and a passion to drive a project on how cellular #senescence and #proteostasis dysregulation contribute to tissue #ageing. Apply by 25th Feb babrahaminstitute.livevacanc…
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No one has accused me of this before...
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Thanks for letting a #Proteostasis geek gatecrash the #ICSA2025Rome party!
International Cell Senescence Association@ICSA_senescence
21 Sep 2025
Day 3 began with Session 7 at #ICSA2025Rome: exploring senescence pathways from mechanisms to therapeutic opportunities. A strong finish to the scientific program!
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We're recruiting a Research Assistant (new grant--details to follow!)--come help us work with primary human patient material to make cool 2D/3D co-culture systems, & learn more about how #proteostasis & #senescence play together in these contexts: babrahaminstitute.livevacanc…
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24-hour pre-conditioning for the Stress Proteins GRC in Maine…
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Back to @EdenProject for the first time in over a decade. Really enjoyed the Invisible Worlds exhibition in the Core.
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Bucket-list weekender for my dad’s 70th.
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Really chuffed to be hosting my PhD supervisor, Paul Workman, for the Babraham Distinguished Lecture today.
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