Deciphering cellular and molecular mechanisms of synaptic function and impact on neuronal circuit output. Viral vector development and CNS gene therapy.

Iowa City, IA
Joined December 2018
For ~25 years Ad vectors had little to no ability to transduce Purkinje cells, until now! Excited to announce our paper in MTMCD @MolTherapy on the development of Ad vectors that transduce Purkinje cells in a humanized mouse model shorturl.at/wyBW5
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Wondered why different synapses have distinct presynaptic Cav2 subtype composition? Read our paper @JPhysiol by grad student @jianing59966408 doi.org/10.1113/JP284957 We define the motifs in Cav2 α1 subunit that control subtype and preference @UIowaResearch @UIowaNeuro
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Cake to celebrate Uchechi and Madhuri being awarded Post Comp Fellowships from the UI Grad College Uchechi is developing gene therapy approaches to treat A-T Madhuri is deciphering the molecular mechanisms for ultrafast synaptic transmission in hearing @UIGradCollege @UIowaACB
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CONGRATULATIONS to Madhuri Bendale who passed her comps on Aug 9 and is an official PhD candidate in the UI CDB Keep an eye on this budding superstar Madhuri's PhD will be on Molecular Mechanisms of ultrafast auditory synaptic transmission @UIowaACB @UIowaNeuro @UIGradCollege
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CONGRATULATIONS to Uchechi Okoroafor, who passed her comps on Friday and is an official PhD candidate in the UI CDB program Keep on eye on this budding superstar Uchechi's PhD will be on Developing Novel Gene Therapy approaches to treat A-T @UIowaNeuro @UIowaACB @UIGradCollege
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Giant Synapse 2023 Nov 10/11 Georgetown University Synapses reign supreme Meeting is free will be multiple trainee talks too please RT @KateOCG @NChanaday @CAndrewFrank @SynapsesInSight @mossy_fibers @JasonSynaptic @JMC_Scientist @KLabGPCR @KT_Kindt @TedAbelneuro @BlackInNeuro
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Giant Synapse update 18 speakers confirmed We have short talk slots for grad students/post docs Meeting is free Nov 10-11 Synapses reign supreme Webpage to come Please RT @KateOCG @JasonSynaptic @SynapsesInSight @CAndrewFrank @HTB_soFLY @TedAbelneuro @PeriKurshan @NeuroBender
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Meet lab member graduate student Uchechi Okoroafor. She was featured on the Noon News at Uiowa tinyurl.com/4k4ststx Uchechi's thesis project is centered on developing gene therapy approaches to treat A-T @UIowaNeuro @uiowabiomed @UIowaACB
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CONGRATULATIONS to Jianing Li @jianing59966408 for being awarded an AHA Predoctoral Fellowship Jianing is solving decades old questions about the mechanisms controlling presynaptic Cav2 channel subtype abundance and organization @AHA_Research @UIGradCollege @UIowaNeuro @UIowaACB
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Interested in deciphering the fundamental questions in cell biology in health and diesease? Come to today's ACB seminar featuring Dr. Joerg Bewersdorf at 11:00 am Dr. Bewersdorf is a leader and pioneer in SMLM and their application in cell biology @UIowaACB @UIowaNeuro @IowaMed
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New piece of lab equipment came today!! Coffee grinder in action.. spreading happiness 5th floor PBDB .. putting the 5 year employment at UIowa present to good. ⁦@UIowaNeuro⁩
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Love synapses! Come to Iowa City for the INI Synapse Symposium for the latest in synapse biology and control of neuronal circuit function. Speaker slots available for PhD students and post docs and poster sessions @Oly_Binewski @RobertsNeuro @dion_synapse @TedAbelneuro
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Resuming our lab tradition of celebrating our papers/grants/awards with cake and coffee. First time since preCOVID days No cupcakes were harmed in this foto
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We had a great week hosting Andi and Amita (front left) from the Mccullagh lab @ZaarlyLiz and showing them the latest greatest tools and techniques in using viral vectors to probe auditory brainstem circuit function @NIDCD @UIowaNeuro Excited to see what future findings are made
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We have grown Excited to have Madhuri Bendale(left) and Uchechi Okoroafor(right) from UI BSP PhD program @uiowabiomed officially join the lab Stay tuned for the exciting discoveries these two talented scientists will make on their PhD journey @UIowaACB @UIowaNeuro @UIGradCollege
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We are excited to give a huge congrats to new ICRU summer fellowship recipient Amanda Dougherty UI Class of 2023 Amanda's undergrad research focuses on Developing Viral Vector Gene Therapy Approaches to treat Cerebellar Ataxias @UIowaACB @uiowabiology @UIowaNeuro @uiowaicru
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Interested in solving how the brain operates? Want to understand how synapses control brain function? Come to todays seminar by Dr. Matthew Dalva at 1:00 pm to hear about his latest research on synaptic plasticity @UIowaNeuro @IowaNeuro @UIowaACB @IowaMed
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It is with a bit of sadness in the lab today as we say goodbye to Paula Valino Ramos a true champion in the lab and on the basketball court We look forward to all her future success and accomplishments in the MSTP program at WUSTL @WUSTLmstp @IowaWBB @UIowaNeuro @UIowaACB
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