@SadhukhanLab

We are an interdisciplinary research group at IIT Palakkad in the Department of Chemistry. Bioorthogonal, Chemoproteomics, Click Chemistry @PalakkadIIT

 IIT Palakkad
sushabhan.wixsite.com/iitpkd-chembiol
Joined June 2022
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  • Followers110
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Thrilled to share our latest research publication!! Kudos to the entire team for their hard work and dedication. @AshishBora72500 @RitikaIITI @meena_lata39640 @SumanMukhopad14 @IITIOfficial @ACSBiomaterials . pubs.acs.org/doi/full/10.102…

Design and Synthesis of Ibuprofen-Based Self-Deliverable Hybrid Gel Systems: Stabilization of...

Abstract. The reported molecule gel-forming component N1,N3,N5-tris­(4-aminophenyl)­benzene-1,3,5-tricarboxamide (TABTA) has been synthesized and character

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Check out the recent publication from Sadhukhan lab, published in ACS applied nanomaterials. Broad spectrum antibacterial action of AgNP with amphiphilic derivatives of EGCG. Congratulations Shabin and the team. pubs.acs.org/doi/10.1021/acs…

Membrane-Active Amphiphilic EGCG Derivatives and Their Silver Nanoparticles-Formulation as Broad-...

Abstract. Eight hydroxyl groups in (−)-epigallocatechin-3-gallate (EGCG) make it difficult to access the hydrophobic domain of bacterial cell membranes and

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@ACS_ANM @ACSPublications @PalakkadIIT
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We are delighted to present the latest findings published in @ACS_Omega. This work showed, inhibition of EGFR by EGCG derivatives led to the activation of cytoprotective autophagy, a resistant mechanism to EGFR-TKIs. Congrats to the team. #EGFR #EGCG pubs.acs.org/doi/10.1021/acs…

4″-Alkyl EGCG Derivatives Induce Cytoprotective Autophagy Response by Inhibiting EGFR in Glioblas...

Abstract. Epidermal growth factor receptor (EGFR)-targeted therapy has been proven vital in the last two decades for the treatment of multiple cancer types

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@PalakkadIIT @ACSPublications @satyamsingh2704
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Give it a read to our recently published article, "Protein S-palmitoylation is markedly inhibited by 4″-alkyl ether lipophilic derivatives of EGCG, the major green tea polyphenol: In vitro and in silico studies" Congrats to the Team. #Palmitoylation #EGCG sciencedirect.com/science/ar…
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@PalakkadIIT @serbonline @IndiaDST
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Check out our recent paper on "Mitochondria targeting EGCG derivatives protect H9c2 cardiomyocytes from H2O2 induced apoptosis" published in @RSCAdvances, @PalakkadIIT Heartiest Congratulations to Revathy, Anupama and @IreneShajan. #EGCG #Cardiomyoctes pubs.rsc.org/en/content/arti…

Mitochondria-targeting EGCG derivatives protect H9c2 cardiomyocytes from H2O2-induced apoptosis:...

Pathologies related to cardiovascular diseases mostly emerge as a result of oxidative stress buildup in cardiomyocytes. The heavy load of mitochondrial oxi

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We are pleased to share our recently published article. This article provides the glimpse of breakthrough discoveries made in EGFR drug Discovery in past 20 years and future strategies to overcome drug resistance. Congrats! @satyamsingh2704 #EGFR #Cancer sciencedirect.com/science/ar…
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We would like to share our recently published collaborative project on Design, synthesis, and applications of pyrene-quinoline based cell-permeable AIEgen for cellular imaging and antibacterial activity. Congratulations to all the authors. @PalakkadIIT sciencedirect.com/science/ar…
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We are happy to share the recent publication by our group member Suchi in the JCCS @WileyGlobal This publication provides the comprehensive role of EGFR and FASN in breast cancer. #EGFR #FASN #breastcancer #cancerresearch doi.org/10.1007/s12079-023-0…
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Congratulations Revathy! For your publication. This is the first report demonstrating a single unmodified non-aromatic amino acid, Lysine as a selective and sensitive fluorescence sensor for detection of Cu2+ and Co2+ along with colorimetric distinction. sciencedirect.com/science/ar…
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Delighted to share that our group member Revathy and colleagues have published a paper on "In situ global proteomics profiling of EGCG targets using a cell permeable click-able bioorthogonal probe". #EGCG #Clickchemistry #Proteomics #Bioorthogonal 1/3 sciencedirect.com/science/ar…
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EGCG, an important polyphenol found in the green tea. EGCG exerts wide range of biological activities including anticancer, antiviral, antioxidant etc. However, it's molecular action mechanism is still unknown. Revathy and colleagues have designed and synthesized a clickable 2/3
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Probe, wherein we have identified several molecular targets of EGCG in the cellular system. 3/3 @PalakkadIIT #Polyphenol #ChemicalBiology
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Hi, This is Satyam and I'm pleased to share my #RSCPoster entitled "A novel 4"-alkyl ether derivatives of green tea polyphenol EGCG as potent and selective EGFR inhibitor". I look forward to hearing from you with any questions/suggestions. #RSCPosterLive #RSCChemBio #RSCMedChem
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Sadhukhan Lab retweeted
The Nobel Prize
@NobelPrize5 Oct 2022
BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
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Sadhukhan Lab retweeted
Satyam Singh@Satyam270423 Sep 2022
Our work on SARS-COV-2, where we have done some preliminary work on plant derived natural polyphenols as SARS-COV-2 RdRp inhibitor. #SARSCoV2 #EGCG #Theaflavin #Polyphenol #Quercetin tandfonline.com/doi/full/10.…

Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA‐dependent...

The sudden outburst of Coronavirus disease (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) poses a massive threat to global public health. Currently, no therap...

tandfonline.com
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Sadhukhan Lab retweeted
Satyam Singh@Satyam270423 Sep 2022
Our Second SARS-COV-2 publication, where we have found some interesting Organosulphur compounds as potential inhibitor candidates against multiple SARS-COV-2 proteins including #PLpro, #Spike, #RdRp, #Mpro, #helicase. #Organosulphur #SARSCoV2 #PhD sciencedirect.com/science/ar…
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Happy to share our newly published article where we have comprehensively covered majority of unexplored areas of EGCG, A Green Tea polyphenol on a chemistry and biology platform. @AcademicChatter @PhDForum @PhDVoice #phdchat #EGCG #Cancer #SARSCoV2 #EGFR tandfonline.com/doi/full/10.…

Chemico-biological aspects of (−)-epigallocatechin-3-gallate (EGCG) to improve its stability,...

Natural products have been a bedrock for drug discovery for decades. (−)-Epigallocatechin-3-gallate (EGCG) is one of the widely studied natural polyphenolic compounds derived from green tea. It is ...

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