@STEM15

Here for the science.

Joined June 2018
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  • Following182
  • Followers9
#Nevada @RepHorsford joins #TheLauraCoatesShow to discuss the "America's Workforce Act" and the companion bill "The National Apprenticeship Act" and the disparate economic impact of the pandemic on women on @SXMPOTUS @SIRIUSXM! Join the conversation!
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“My CV makes it look easy, but it hasn’t always been. For every paper or grant I have submitted, 80-90 % of them have been rejected, which is why I tell my students they have to love the pursuit of the question.” -⁦@CDCDirector⁩ ⁦@RWalensky⁩ vogue.com/article/dr-rochell…

Science Not Politics: How Dr. Rochelle Walensky is Saving the CDC

vogue.com
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Watch RAS wiggle! Here is our latest structure showing dynamics of a KRAS mutant found in RASopathies - KRAS P34R (mutation in red). Interesting connection with heterotrimeric G proteins. onlinelibrary.wiley.com/doi/….
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ICYMI - informed and thoughtful perspectives on Preparing for the Next Pandemic from an extraordinary leader, Dr. @SueDHellmann, who has led important institutions across sectors including @gatesfoundation and @UCSF. @WSJ
Dr. Sue Desmond-Hellmann@SueDHellmann3 Apr 2020
Ending the week sad about terrible suffering - so I took a shot at how we can do better next time. Preparing for the Next Pandemic - WSJ #COVID wsj.com/articles/preparing-f…

Preparing for the Next Pandemic

The Covid-19 crisis has clear lessons for what we can do now to stop a future global health emergency

wsj.com
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Doctors, nurses & ALL healthcare providers need adequate Personal Protective Equipment so they can treat patients without spreading COVID & also safely protect themselves. Everyone can help us! Here is how: CC: @DarilynMoyer @ACPinternists Please share w/ everyone you can🙏
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This past week has challenged each of us in unique ways, but we can all share the common experience of confronting unexpected challenges. We also share the truth that we can’t do this alone. Don’t be afraid to ask for help, and don’t be afraid to offer help to others.
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Dear elected officials for NC, we need some help. Please help us find #3Dprinters in the Charlotte area. We need #faceshields #masks #PPE for our healthcare teams caring for pts. #COVID19 We need printers, supplies, & some humans to help. Thx 🇺🇸 – at Charlotte, NC
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There is no treatment for 90% of rare diseases. Personalised medicines can target such illnesses econ.st/3cZVmN6
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Following guidance from the @StateDept and @CDCgov and #UNC’s prohibition of travel outside of North Carolina, all summer 2020 study abroad and international education programs are canceled. This includes undergraduate, graduate and professional programs unc.live/3cWFV8x
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"Individualized medicine, for us, is really understanding as much about each individual patient as we possibly can,” says @akeithstewart. to.pbs.org/308UBv7 via @NewsHour @PBS @milesobrien

How a growing trove of genetic data is informing medical breakthroughs

Individualized medicine, in which treatments are customized based on a patient’s unique DNA, is a rising field. Along with an ever-expanding genetic database, it offers tantalizing promise for...

pbs.org
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Many thanks to our many collaborators and colleagues, and to our funders for supporting this work
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To all my macrophage friends: check out this awesome work by @ashishkulkarny and co-workers. Dual‐inhibitor‐loaded nanoparticles target M2 macrophages and simultaneously inhibit CSF1R and SHP2 pathways to repolarize TAMs.
Ashish A. Kulkarni@TheKulkarniLab29 Oct 2019
Just out in Advanced Materials!! I am so so proud of my students, Anujan, Sahana and Dipika!! "CSF1R‐ and SHP2‐Inhibitor‐Loaded Nanoparticles Enhance Cytotoxic Activity and Phagocytosis in Tumor‐Associated Macrophages" @AdvSciNews @UMassChemEng @umassengin onlinelibrary.wiley.com/doi/…
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Clinically, this suggests that this resistance can be potentially overcome by targeting the specific RTK resistance mechanism — or perhaps by targeting nodes of convergence like MEK or ERK or SHP2, which would allow treatment of more disparate resistance mechs w fewer drugs
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.@DrMonicaGuzman & colleagues analyzed PTPN11-mutated #AML samples for sensitivity to epichaperome inhibition, a new cancer-targeting strategy. Findings were presented at #ASH19 by @WeillCornell @nyphospital Hem/Onc Fellow Dr. Justin Kaner (@WxMD529). bit.ly/2qdEP4C
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Insights into sorption and desorption mechanisms of PFOA’s cationic and zwitterionic precursor compounds ow.ly/Btly50wItIn
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Happy #PhytochemicalFriday! Today: allicin, a (zwitterionic!) compound from garlic. Normal garlic cells contain alliin (an amino acid-like compound), but crushing garlic exposes alliin to an enzyme that converts it into allicin - the major contributor to the aroma of fresh garlic
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A paper recently published in @nature from @liugroup discloses a ‘prime’ gene-editing system many years in the making. It has already been snapped up as the key founding intellectual property for Cambridge, Massachusetts-based startup Prime Medicine
Nature Biotechnology
@NatureBiotech8 Nov 2019
Gene editing enters ‘prime’ time. Early results suggest that prime editors are cleaner than CRISPR–Cas9 and more versatile than base editors, but many questions remain nature.com/articles/d41587-0…
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New Research: Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells: Non-mammalian vertebrates, including zebrafish, retain the ability to regenerate hair cells (HCs) due to unknown… frontiersin.org/articles/10.… #Neuroscience
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