MD, MPH | #RadRes @YaleRadiology | s/p @TehUofMed, @UCSDHealthSci, @StanfordGenSurg | Member-in-training @LIRADS5 and @radiology_rsna
New Haven, CT
Joined April 2022
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1/8 🧵
Can #HCC extend beyond the margin we see on grayscale ultrasound?
New @radiology_rsna study explores “perfusion beyond margin” (PBM), #CEUS feature that may peak into tumor aggressiveness & prognosis.
#RadInTraining
@RITEditor @RadiologyEditor @SuhnyAbbara @VChernyakMD
7/8
And the biology went even deeper.
RNA sequencing showed PBM-associated changes involving:
- Angiogenesis
- Epithelial-mesenchymal transition
- An immunosuppressive tumor microenvironment
This provides a possible biologic explanation for what is being seen on CEUS.
8/8 Take-home:
The visible tumor margin may not tell the whole story. "Perfusion beyond margin" on CEUS may identify HCCs with vascular extension beyond their grayscale more invasive phenotype.
Read more: pubs.rsna.org/doi/10.1148/ra…
1/12
Can non-contrast abbreviated MRI (NC-AMRI) be used for post #TACE surveillance of #HCC? New in @radiology_rsna: performance of NC-AMRI using #LIRADS ancillary features for post-TACE treatment response assessment.
#RadInTraining
@RITEditor @RadiologyEditor @SuhnyAbbara
11/12
The authors conclude NC-AMRI demonstrates moderate diagnostic performance for post-TACE treatment monitoring but remains inferior to full-sequence liver MRI.
Its potential role may lie in selected surveillance settings rather than routine replacement of standard imaging.
12/12
This study contributes to the growing literature exploring aMRI protocols and their role in improving the accessibility and efficiency of #HCC surveillance and treatment monitoring.
Read the article in Radiology: pubs.rsna.org/doi/10.1148/ra…
@VChernyakMD
