Senior Computational Biologist @ Pfizer | Neuroscience PhD @ WashU | Alzheimer’s disease | microglia | neuroinflammation | opinions are my own
Cambridge, MA
Joined November 2017
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Shih-Feng You retweeted
Original Article: In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia nej.md/3QXnXeG
Editorial: A New Approach to Lowering LDL Cholesterol nej.md/4grOSJB
#Genetics #Cardiology
ALT A detailed infographic illustrating in vivo gene editing of hepatocyte PCSK9 with VERVE-102. The top section depicts the liver and a lipid nanoparticle containing VERVE-102 components. The middle section explains the delivery of VERVE-102 to hepatocytes. The bottom section outlines how VERVE-102 inactivates PCSK9 gene through base editing. The entire infographic visualizes the medical and scientific process clearly.
Shih-Feng You retweeted
Researchers in Science report the development of a general-purpose biomedical AI agent that can help automate biomedical research workflows.
The authors say their results point “toward a future in which AI agents work alongside human researchers to accelerate biomedical discovery from basic research to translation.”
Learn more: scim.ag/4wDCtIw
Shih-Feng You retweeted
This week in medicine
- Novo Nordisk's anti-inflammatory IL6 inhibitor fails to prevent cardiovascular events
- Latigo Biotherapeutics' non-opioid NaV1.8 inhibitor had opioid-level pain relief in a phase 2b trial
- Argenx agreed to acquire Forte Biosciences and their first-in-class CD122 inhibitor for vitiligo
- Altimmune’s GLP-1/glucagon agonist helps treat alcohol use disorder
- Gilead/Merck's once-weekly pill matches the once-daily alternative for HIV treatment
- Caltech scientists developed an electronic skin for non-invasive monitoring of fatigue
- Novo Nordisk's GLP1-amylin co-agonist, Zenagamtide, had positive phase 2 trials in type 2 diabetes - both the injectable and pill form
- Stanford scientists find that clonal hematopoesis might actually protect against Alzheimer’s
- Replimune’s oncolytic virus moved closer to approval for treatment of melanoma
More here! breakingground.substack.com/…
Milestone
Presented at #ASCO26:
Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: nej.md/4nWaxvM
@ASCO
ALT Graph from a study published in the New England Journal of Medicine on daraxonrasib versus chemotherapy for metastatic pancreatic cancer. The x-axis represents months, and the y-axis shows the percentage of patients alive. Two lines indicate survival rates: daraxonrasib (blue) and chemotherapy (gray). The bottom section lists patients at risk over time. Title and journal logo are included.
Shih-Feng You retweeted
Alzheimer’s disease does not begin with memory loss.
It begins when your episodic memory network loses its ability to deactivate under load, driven by amyloid and tau disrupting synaptic signaling, which means your cognitive precision starts degrading years before you notice it. @NatureComms
Top medical journal posts a AI generated image as feature photo, it’s been three days and seems no one in @NEJM feel like to retract it. This showcases how much our academic and publication system paralyzed by AI.
An 87-year-old man presented with difficulty breathing after having inhaled thick smoke from a forest fire for several hours. Respiratory failure developed. On flexible bronchoscopy, black casts were seen in the airway. Read the full case details: nejm.org/doi/full/10.1056/NE…
ALT Images in Clinical Medicine Climate Change Bronchial Casts from Inhalation of Forest-Fire Smoke A photo of the bronchial casts from the inhalation of particulate matter from forest-fire smoke
Shih-Feng You retweeted
To understand most genetic signals for human disease that are located in non-coding regions, we will need to explore their effects on gene expression at the single-cell level.
Two new valuable resources apply this in brain tissue and neurological disease👇
Shih-Feng You retweeted
Aging isn't just a dimmer switch; it’s a logistics failure. In @NatureAging, Doug Henze, Tony Wyss-Coray, and I show how mRNA "gets stuck" in aging microglia, causing degradation of their spatial context: nature.com/articles/s43587-0…
Shih-Feng You retweeted
Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation
nature.com/articles/s41590-0…
Shih-Feng You retweeted
📢 Preprint: we present a whole-mouse-brain in vivo Perturb-seq atlas, 7.7 million cells, 1947 disease-associated perturbations, moving toward direct readout of how human genetics rewires cell states & circuits in vivo. Grateful for the Team! @NVIDIAHealth biorxiv.org/content/10.64898…
Shih-Feng You retweeted
Spatial perturb-seq: single-cell functional genomics within intact tissue architecture
Scale up your in situ CRISPR screens
Out in @NatureComms
Shih-Feng You retweeted
geneSTRUCTURE: A Modern Platform for Visualization of Gene Structures biorxiv.org/content/10.64898… 🧬💻🧪 github.com/hashimotoshumpei/…
Shih-Feng You retweeted
做生物、医学的朋友可以关注这个 skills：OpenClaw Medical Skills 震惊到，872个医学AI agent技能集全，从临床到生信、药物发现、医疗器械、健康管理一应俱全。
是时候让你的🦞学会医疗技巧了，一个🦞就是一个生物学信息医学信息专家： github.com/MedClaw-Org/OpenC…
Shih-Feng You retweeted
#SpatialTranscriptomics
Optimizing Xenium @10xGenomics In Situ data utility by quality assessment & best-practice analysis workflows
If you are a Xenium user, this is a must-read🔥
👉Segmentation: Cellpose + Baysor (Segmentation-free alternative: SSAM, Points2Regions)
👉Preprocessing: Library size normalization, log-transformation, scaling, k-nearest neighbors graph (all PCs + 16 neighbors), Louvain clustering
👉Spatially variable feature selection: Squidpy Moran's I, Seurat Moran's I, Sinfonia, SomDE, Giotto, Hotspot
👉Imputation: SpaGE, Seurat, Tangram, SpaOTsc
👉Spatial domain identification: binning-based strategy, Bansky, SPACEL
Performance
vs CosMX, Molecular cartography, MERFISH, MERSCOPE, high-sensitivity ISS
@naturemethods 2025
nature.com/articles/s41592-0…
Shih-Feng You retweeted
PlotGDP: an AI Agent for Bioinformatics Plotting
researchhub.com/paper/110751…
Shih-Feng You retweeted
A mouse circadian proteome atlas - it's a monster cell.com/molecular-cell/full…
Shih-Feng You retweeted
PET tracers specific for activated and homeostatic microglia are in the works. One targets TREM2, the other P2Y12R. #alzheimersdisease @LMU_Muenchen ow.ly/kPJO50YcBGN
Shih-Feng You retweeted
Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases
nature.com/articles/s41590-0…
