@SEBASOLE

Director Médico en Clínica IRAM // Profesor Titular en Universidad Diego Portales

 SANTIAGO, CHILE
youtube.com/user/sebasole10
Joined July 2010
  • Tweets2.5K
  • Following2.1K
  • Followers1.5K
163Media
SEBASTIAN SOLE retweeted
Dr Rishabh Jain
@DrRishabhOncoOct 16
🚨 ESMO 2026: A new treatment algorithm for localized gastric & oesophageal cancer! 🔹 Oesophageal SCC: CROSS → Surgery → Adjuvant nivolumab (if residual disease) 🔹 Gastric/GEJ adenocarcinoma: Perioperative D-FLOT + durvalumab maintenance is now preferred. 🔹 Early-stage disease: Endoscopic or surgical resection. 🔹 Unresectable/unfit: Definitive chemoradiotherapy. The key shift: Immunotherapy is now integrated into curative-intent treatment for selected patients. #ESMO2026 #GastricCancer #EsophagealCancer @ASCO @oncoalert
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SEBASTIAN SOLE retweeted
PDBrown
@PDBrownOncOct 10
Sham controlled Randomized Trial Low Dose Radiation Therapy Knee Osteoarthritis · LDRT signif response · Sup responder rate persisted out to 8 mo
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SEBASTIAN SOLE retweeted
The Lancet
@TheLancetOct 11
ICYMI - Radiotherapy after surgery halves risk of recurrence in a type of brain tumour that can often grow back, trial shows. Find out more in The Lancet: spkl.io/60147VN0i #EANO2026 @EANOassociation
Kaplan\u2013Meier estimates of disease-free survival by treatment group in the intention-to-treat population. Median follow-up was 64 months (IQR 50\u201375). HR=hazard ratio. Copyright: 2026 The Author(s). Published by Elsevier Ltd. CC BY 4.0.

ALT Kaplan\u2013Meier estimates of disease-free survival by treatment group in the intention-to-treat population. Median follow-up was 64 months (IQR 50\u201375). HR=hazard ratio. Copyright: 2026 The Author(s). Published by Elsevier Ltd. CC BY 4.0.

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SEBASTIAN SOLE retweeted
NonsparseOncologist@5_utrOct 10
Every cancer organ gets the same sequence: surgery is the standard, then trials show you often don't need it, then surgery becomes the salvage. Breast, larynx, limb, rectum, esophagus, mesothelioma. Bladder is next. Patients want their organs. 🧵
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SEBASTIAN SOLE retweeted
RadOnc Tables@RadoncTablesOct 4
Was this one of the greatest ASTROs ever? Lots of updates on the tables from this year’s event, also publication of ROADS & ROAM GETUG P05 RTOG 0534 SPPORT ALLIANCE 071801 Russia LDRT osteoarthritis NRG CC009 STELLAR 2 MAVERICK ARST 0531 & 1431 COPORT RTOG 0815 ROADS ROAM
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SEBASTIAN SOLE retweeted
Drew Moghanaki
@DrewMoghanakiOct 4
🇯🇵 Provocative update from JCOG 0802 again shows that lobectomy is associated with inferior OS when stage I NSCLC is managed surgically. This time, among pts with high-risk pathological findings (LVI, VSI, pleural invasion, or LN metastasis). This rekindles the aphorism that wider surgical margins don't always = better outcomes, even though lobectomy improves RFS. jto.org/article/S1556-0864(2…
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SEBASTIAN SOLE retweeted
Angel Montero Luis@Monthy_AOct 1
First-in-human application of craniospinal LDRT for progressive MS demonstrates remarkable clinical efficacy with rapid improvement in disability and quality of life measures #radonc #ldrt #ASTRO26
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SEBASTIAN SOLE retweeted
Federica Ferrario@Fefe_FerrarioSep 29
So proud of our #POPART around the 🌍 superbly presented by @PanizzaDenis 👏🏼 @StAr_MCM74 @valefacc22 @CChissotti @CiroFranzese1 @Raffa_Lucchini @roberta_muni
Daniel E Spratt
@DrSpratticusSep 29
Post-prostatectomy RT in just 5 fractions? 👀 Ferrario et al and POPART team reports 100 pts treated with prostate-bed SBRT (32.5 Gy/5 fx): • Late ≥G2 GU toxicity: 8.5% • Only 1 late G2 GI event • Just 3 in-field relapses • 30-mo biochemical control: 74% Very encouraging local control and toxicity—but urinary QoL remains important to watch. #ASTRO26 #ProstateCancer #SBRT @HimanshuNagarMD @rtdess @RadOncDocJ @angela_jia_ @urotoday @TylerSbrt
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SEBASTIAN SOLE retweeted
Jaime Mañalich
@jmanalichSep 30
Muertes evitables. Chile con el mejor sistema de salud de América latina.
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#ASTRO26 @ASTRO_org Day 4 Selfie 4 After spanish session Reirradiation ☢️👏LATAM #Boston
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SEBASTIAN SOLE retweeted
Daniel E Spratt
@DrSpratticusSep 29
Across 3 prospective studies, the signal for post-prostatectomy SBRT in 5 fx is increasingly consistent: feasible, low toxicity & excellent in-field control. StereoBed randomized data show no PRO/toxicity penalty; POPART/esSBRT show few local failures. #ASTRO26 @rtdess @HimanshuNagarMD @RadOncDocJ @NRGonc @ASTRO_org @urotoday @ChadTangMD @TylerSbrt @SbrtSean @jryckman3 @seanmmcbride
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SEBASTIAN SOLE retweeted
Daniel E Spratt
@DrSpratticusSep 29
Post-prostatectomy RT in just 5 fractions? 👀 Ferrario et al and POPART team reports 100 pts treated with prostate-bed SBRT (32.5 Gy/5 fx): • Late ≥G2 GU toxicity: 8.5% • Only 1 late G2 GI event • Just 3 in-field relapses • 30-mo biochemical control: 74% Very encouraging local control and toxicity—but urinary QoL remains important to watch. #ASTRO26 #ProstateCancer #SBRT @HimanshuNagarMD @rtdess @RadOncDocJ @angela_jia_ @urotoday @TylerSbrt
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#ASTRO2026 @ASTRO_org @SEBASOLE Reirradiacion de Recto Muy elegante presentación!!!
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SEBASTIAN SOLE retweeted
Zach Klaassen
@zklaassen_mdSep 28
#ASTRO26 Plenary -- PACE-A: 5-yr Outcomes of RP vs SBRT for GG1-2 PCa @nickva1 @urotoday 📍n=123 (60 RP, 63 SBRT), mFU 8 yrs, 10 🇬🇧 centers 📍13 BCF events: HR 0.48, 95% CI 0:16-1.46 📍7 deaths (no PCa): HR 0.55, 95% CI 0.12, 2.46 📍EPIC-26 >=1 urinary pad: 14/29 (48%) RP vs 3/36 (8%) SBRT 📍EPIC-26 bowel bother: 1/28 (4%) RP vs 0 SBRT
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#ASTRO26 @nickva1 presents 5 yr data of PACE-A: SBRT v RP no differences in clinical outcomes use of =1 urinary pad 8.3% SBRT V 48% RP Low GI/GU events <%4 each arms
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SEBASTIAN SOLE retweeted
Alison Tree 💙@alison_treeSep 28
Replying to @nickva1
@nickva1 @royalmarsdenNHS presenting 5 year outcomes of PACE-A @EmmaHall71 Surprised to see numerically less bowel bother in the SBRT arm, noting small numbers. Await sexual outcome data tomorrow @ASTRO_org #ASTRO26
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SEBASTIAN SOLE retweeted
Dr Najeed Aadil@daakhsaabSep 28
☢️ #ASTRO26: LDRT in knee OA is fascinating. 292 patients | 4.5 Gy/10 fractions At 3 years: 🦵 VAS pain: 21 vs 55 📈 Responders: 69% vs 25% (p<0.0001) Long-term: disability 14% vs 25%; KL-2 knee replacement 14% vs 36% (HR 0.32, p=0.021).
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SEBASTIAN SOLE retweeted
NonsparseOncologist@5_utrSep 27
‼️ PACE-A Ph3 RCT SBRT(36.25/5) vs RP Median f/u 8 years bPFS HR 0.48 (0.16-1.46), 8-year rates of 91.2% (80.1-96.2) vs 83.7% (68.4-92) in favor of SBRT 48% pad use RP vs 8.3% SBRT at 5 years Wow #ASTRO26
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SEBASTIAN SOLE retweeted
Jeff Michalski@jmmradSep 28
Dr vanAs reports results of PACE-A confirming that SBRT is a safe, effective alternative to radical prostatectomy. Don’t miss the QoL results to be updated soon!
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SEBASTIAN SOLE retweeted
Hernan Letelier@hletelierSep 28
🚨 #ASTRO2026 PACE-A trial / Prostate Cancer – 5-year follow-up ✅ Similar OS: 98% vs 98% at 5 years ✅ Better urinary continence with SBRT: 8% vs 48% reporting ≥1 pad 🔥 ✅ No significant differences in late GI side effects: 0% vs 4% reporting moderate/big bowel problems 🚀
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