All the influencers are losing it over the new report that intermittent fasting is associated with a 91% increase in heart disease death. Obviously many caveats, and not published yet so don't know what other flaws exist, but this seems like a pretty big effect and probably worth not ignoring completely, just because you don't want to believe it's true washingtonpost.com/wellness/… I've said all along that fasting/intermittent fasting/time restricted eating have little to no benefits if not also paired with a reduction in overall caloric intake. The animal data seem clear on this, at least from a longevity and healthspan perspective. We published a comprehensive review on this a couple of years ago. ncbi.nlm.nih.gov/pmc/article… Intermittent fasting or time-restricted eating in people can lead to reduced muscle mass - seen previously and also in the recent reports. That can likley be overcome by diet quality and resistance training, but requires some thought and effort. Loss of muscle mass is a problem and may be contributing to increased mortality here and in general. My advice: (1) If you want to do IF/TRF to control weight, you really need to focus on a high quality diet and do some resistance exercise to maintain muscle mass (2) If your doc or favorite internet personality isn't telling you this, you may want to seek information elsewhere (3) Don't do IF/TRF because you think it promotes longevity. It doesn't, even in mice, unless it's in the context of caloric restriction