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What SNP variation is sufficient to connect an outbreak strain with its potential environmental source?
Check out what we learned from genomic analyses of a Serratia marcescens outbreak.
Appreciate the collaborative efforts of all involved!
mdpi.com/1660-4601/20/17/670…
New paper out on Serratia marcescens outbreak. Thanks to all my colleagues at MCPHL, CCHCS, and CDPH who brought this work to fruition.😁 mdpi.com/1660-4601/20/17/670…
Rahil Ryder retweeted
SARS-CoV-2 saltation variant PJ.2.1 has raised concerns over another JN.1-like event.
Here we found:
1. PJ.2.1 shows markedly higher ACE2 binding.
2. PJ.2.1's antigenicity remains comparable to the JN.1 family.
3. No increased immune evasion against human plasma.
While PJ.2.1 currently lacks the immune evasion capabilities of other contemporary strains (XFG, PQ.16.1.1, BA.3.2.2...), its robust baseline receptor-binding strength mirrors the early evolutionary trajectory of BA.2.86 to JN.1, necessitating continued genomic, epidemiological, and virological surveillance of the PJ.2.1 lineage.
Details can be found in the recent BioRxiv manuscript:
biorxiv.org/content/10.64898…
Rahil Ryder retweeted
#ConvMut is finally free at the @GISAID .org platform to facilitate vaccine & mAb manufacturers.
@lsubissi @RajlabN @MarionKoopmans
@SolidEvidence @BenjMurrell @SystemsVirology @tylernstarr @JPWeiland @CorneliusRoemer @ilariacapua @yunlong_cao
@Invivyd @moderna_tx
H/t @polimi
‼️🚨 #ConvMut is finally ready! Our Christmas 🎁 for the variant seekers community: automated charting and analysis of convergent evolution in SARS-CoV-2, developed by @dslab_polimi (#1 University in Italy). Preprint here👇
biorxiv.org/content/10.1101/…
Rahil Ryder retweeted
In new study led by @timcyuu, we measure how mutations to H3 flu HA affect cell entry, stability & antibody escape
We find pleiotropic effects of mutations on these phenotypes shape evolution: epistasis alleviates cell-entry but not stability constraints
biorxiv.org/content/10.1101/…
Rahil Ryder retweeted
Monitoring viral evolution at population scale (in almost real-time) for the first time in the history of virology is leading to unprecedented findings like this
Rahil Ryder retweeted
Interested in #BirdFlu ? Follow the @WHO virtual meeting on #H5N1 preparedness on Mar 19.
Free registration at this link: who.zoom.us/webinar/register…
Includes epidemiology, antivirals and vaccines (my talk).
@PeacockFlu @HelenBranswell @DuckSwabber @MichaelWorobey @EricTopol
Amazing work by the Nextstrain team detailing H5N1 cattle outbreak.
nextstrain.org/blog/2024-06-…
Excited to share our preprint on SARS-CoV-2 recombinants in California.
preprints.org/manuscript/202…
I got it too!
Just got my hands on "The Applied Genomic Epidemiology Handbook" - a game-changer for public health pros! 📚 Major kudos to @alliblk (@WADeptHealth), @evogytis (@VU_LT), with contributions from @EpiDemos82 (@UCF), and Janeece Pourroy (@ChanZuckerberg). It's packed with practical tips & real-world case studies on leveraging pathogen genomic data. A must-read for anyone in #PublicHealth or #GenomicEpidemiology.
And even better - you can get it on Amazon: amazon.com/dp/103253026X?psc…
#Epidemiology #PathogenGenomics
We're looking for a Research Scientist Supervisor I. This position supports the California Department of Public Health’s (CDPH) mission and strategic plan by providing scientific leadership on SARS-CoV-2 and coordinating with partners working on other respiratory viruses.
Genomics Unit Chief Classification: RESEARCH SCIENTIST SUPERVISOR I (EPIDEMIOLOGY/BIOSTATISTICS) $8,984.00 - $11,196.00# of Positions: 1 Work Location: Sacramento County Telework: Hybrid Job Type: Permanent, Full Time calcareers.ca.gov/CalHrPubli…
This recruitment is posted in the Sacramento and Contra Costa County locations. Final Filing Date: 3/28/24 Position Details Job Code #: JC-419501 Position #(s): 581-410-5643-909
Rahil Ryder retweeted
Joint statement by @UNDP, @UNFPA, @UNICEF, @WFP and WHO on humanitarian supplies crossing into Gaza
A first, but limited, shipment of life-saving humanitarian supplies from the United Nations and the Egyptian Red Crescent entered Gaza today on 20 trucks, passing through the Rafah Crossing.
It will provide an urgently needed lifeline to some of the hundreds of thousands of civilians, mostly women and children, who have been cut off from water, food, medicine, fuel and other essentials. But it is only a small beginning and far from enough. More than 1.6 million people in Gaza are in critical need of humanitarian aid. Children, pregnant women and the elderly remain the most vulnerable. Nearly half of Gaza’s population are children.
With so much civilian infrastructure in Gaza damaged or destroyed in nearly two weeks of constant bombings, including shelters, health facilities, water, sanitation, and electrical systems, time is running out before mortality rates could skyrocket due to disease outbreaks and lack of health-care capacity.
Hospitals are overwhelmed with casualties. Civilians face mounting challenges in accessing essential food supplies. Health facilities no longer have fuel and are running on small amounts they have secured locally. These are expected to run out in the next day or so. Water production capacity is at 5 per cent of normal levels. Pre-positioned humanitarian supplies have already been depleted. Vulnerable people are at greatest risk and children are dying at an alarming rate and being denied their right to protection, food, water and health care.
Nearly one-third of the population of Palestine was food insecure before this conflict in Gaza. Today stocks in shops are nearly exhausted and bakeries are closing, while tens of thousands of people are displaced and unable to cook or safely purchase food.
We call for a humanitarian ceasefire, along with immediate, unrestricted humanitarian access throughout Gaza to allow humanitarian actors to reach civilians in need, save lives and prevent further human suffering. Flows of humanitarian aid must be at scale and sustained, and allow all Gazans to preserve their dignity.
We call for safe and sustained access to water, food, health – including sexual and reproductive health – and fuel, which is necessary to enable essential services.
We call for the protection of all civilians and civilian infrastructure in Gaza, including health-care facilities.
We call for the protection of humanitarian workers in Gaza who are risking their lives in the service of others.
And we call for the utmost respect of international humanitarian law by all parties.
Gaza was a desperate humanitarian situation before the most recent hostilities. It is now catastrophic. The world must do more.
I got into the public health field as an APHL Associate. Loved the work and where it brought me.
The #APHLFellowship is in full bloom today with the launch of applications for the next cohort! The Public Health Laboratory Fellowship Program invites students ready to advance their career in public health laboratory science to apply. Learn more at buff.ly/3AX0HT9
Highly recommend the CSUMB class Bioinformatics (BIO410/510) taught by @DrJueFish for all students interested in biology/genomics. Bioinformatics is the future and there is a lot of job growth! I would not be where I am today without this class.
@CSUMB @csumb_aes @csumbscience
Rahil Ryder retweeted
Drop a 💙if you are thankful for Dr. Fauci's more than 50 years of public service to the American people.
Rahil Ryder retweeted
Excited for my graduate student Rahil Ryder to defend her Masters thesis this coming Tuesday. If you're near campus, swing by in-person or register for a zoom link here: shorturl.at/gzCKZ.

























