@RossjohnLab

Led by Prof @Jamie_Rossjohn FRS we are focused on understanding molecular bases underpinning protective and aberrant immunity

 Monash University, Australia
rossjohnlab.com
Joined July 2014
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  • Followers1.5K
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In collaboration with labs @PN0rmski @KatherineKedz @AndrewB34372462 @syctong and co-authors, paper published @MonashUni: An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania: Cell cell.com/cell/fulltext/S0092…

An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First...

Predominant genetic variants found in First Nations peoples of the Oceania region influence the function of natural killer cells and may explain population-specific susceptibility to diseases,...

cell.com
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Rossjohn lab retweeted
Klebanoff_Lab@KlebanoffLabMar 18
🚨🧬An in vivo cell therapy engineering platform of transformative potential. Congratulations to @j_eyquem and team on a breathtaking (and groundbreaking) body of work. @parkerici @UCSF nature.com/articles/s41586-0…

In vivo site-specific engineering to reprogram T cells

Nature - Stable and cell-specific transgene expression can be achieved through in vivo site-specific integration of large DNA payloads using a two-vector system of enveloped delivery vehicles and...

nature.com
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NHMRC Investigator Grants out today. A devastating day for many. I have already received messages from some of the best researchers I know who have missed out. The senior levels had a cutoff of 5.93 (females), 6.2 (males) - according to my sources. The impact will be wide spread. The damage being done at the moment to the sector is totally unacceptable. We need to do a lot more to support our research community.
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#StarsOfScience – Professor Jane Visvader's groundbreaking discoveries at @WEHI_research have fundamentally changed how we understand breast development and cancer.

Prof Jane Visvader – Ruby Payne-Scott Medal and Lecture 2025

Working at WEHI, Jane’s breast stem cell discoveries reshaped cancer science, revealing BRCA1 cancer origins and sparking a global prevention trial for high-risk women.

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Congrats to PhD student, Liam Rashleigh, whose 1st authored paper on gd T cell receptor recognition was published today @Structure_CP cell.com/structure/fulltext/… #GDTcellclub @MonashUni @RossjohnLab

Antibody-like recognition of a γδ T cell receptor toward a foreign antigen

Rashleigh et al. utilized phycoerythrin, a bacterial derived protein, to explore immune reactivity of B cells, αβ T cells, and γδ T cells. All lymphocytes directly recognized PE, while T cell...

cell.com
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Early bird registration pricing for CD1-MR1 2025 ends this Friday, 6th June! Get on it 👉👉 cd1mr1.com
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Congrats to Hien, 1st author of this study that arose from her hard work during her PhD.
Peeref@Peeref12 Jun 2025
Latest research from @jbiolchem “The molecular basis of T cell receptor recognition of citrullinated tenascin-C presented by HLA-DR4” by Dao et al. jbc.org/article/S0021-9258(2… @ASBMB @Jamie_Rossjohn
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In collaboration with Moody lab, latest paper from @RossjohnLab describing the structure of a lipopeptide bound to a MHC-I like molecule found in chickens - hopefully this study will not ruffle too many feathers.
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Your immune system gradually loses it top team players when we get older 👱➡️👵 Our study in @eBioMedicine investigates how long our good immune cells stay around – a 🧵⬇️ go.unimelb.edu.au/4sep @CvandeSandt @KatherineKedz @TheDohertyInst #Influenza #AgingResearch
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Our latest paper demonstrating the potential of “our” DOT cells against colorectal cancer has just been published in @NatureCancer: rdcu.be/ehYwG Many congrats to the whole team, especially @RafaelBlancoDom! :)
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Recent paper from lab describing a peptide-independent MHC-restricted T cell receptor nature.com/articles/s41467-0… in collaboration with La Gruta lab @MonashUni @Monash_FMNHS @RossjohnLab @NatureComms

A naturally selected αβ T cell receptor binds HLA-DQ2 molecules without co-contacting the presented...

Nature Communications - T cell receptors co-recognizing both MHC and antigenic peptide for a tri-party specific interaction has been a central dogma of T cell-mediated responses. Here the authors...

nature.com
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In collaboration with @NicoleLaGruta1 and colleagues, latest paper from @Jamie_Rossjohn lab describing role of Lck-coreceptor assocation in T cell function. @MonashUni science.org/doi/10.1126/scii…

LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR...

LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.

science.org
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Researchers in Science #Immunology have identified CD8+ T cells from human donors that can recognize naturally occurring influenza variants spanning more than 100 years, including the 1918 influenza A and 2024 #H5N1. @Jamie_Rossjohn @kedzierskalab scim.ag/4hpSzh1
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🚨 Flu breakthrough! 🚨 Researchers at @TheDohertyInst & @MonashUni have discovered immune cells that recognise flu viruses even as they mutate—a further step toward a universal flu vaccine. go.unimelb.edu.au/d7z8 @UniMelbMDHS @TheRMH @oanheei @Jamie_Rossjohn @kedzierskalab @KatherineKedz
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Our latest study @SciImmunology identifies the molecular determinants of cross-reactive B35/NP418-restricted CD8+ T cells across IAVs from 1918 H1N1 to 2024 H5N1, and assesses their functionality. @KatherineKedz @RossjohnLab science.org/doi/10.1126/scii…

Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors

TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.

science.org
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Rossjohn lab retweeted
Waggoner Lab@LabWaggoner7 Feb 2025
TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants @SciImmunology science.org/doi/10.1126/scii… @RossjohnLab @Jamie_Rossjohn @kedzierskalab @KatherineKedz
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science.org/doi/10.1126/scii… First paper from the @JohnstoneLab for the year and a brilliant collaboration with @TheDohertyInst colleagues Dan Utzschneider and Alex Kallies. Thanks to all @PeterMacRes @PeterMacCC for help and support and great job Dane Newman and Leonie Cluse!

Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3...

ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.

science.org
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Ziggy enjoying park time #roughcollie
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Researchers paid $8.968 billion for their findings to be freely accessible. 🧵1/10
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abc.net.au/news/science/2025…

Forty-one species added to Australia’s threatened list despite zero extinction target

A number of animals, plants and an entire ecosystem were added to Australia's extinction watch list in 2024. We look at the new species under threat.

abc.net.au
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Latest paper from lab, where Awad et al describe how cigarette smoke impacts that MAIT-MR1 axis and implications for lung diseases. In collaboration with Fairlie, Hansbro and Corbett labs doi.org/10.1084/jem.20240896 @MonashBDI @nhmrc @WaelAwadMoh @MonashUni @Jamie_Rossjohn @JExpMed

Cigarette smoke components modulate the MR1–MAIT axis

Cigarette smoke is a diverse mix of chemicals that bind the antigen-presenting protein MR1 and modulate MAIT cell function in the lung through diverse mech

rupress.org
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