Today we are launching RootPath BinderVerse, a cloud lab for AI-designed binders. Sequence in, binding data out in as few as 3 days, gene synthesis time included! Antibodies and Fab fragments made with CHO cells (TAT from 6 days) and CAR-Ts made with primary T cells (TAT from 10 days) can also be created from your binder sequences and tested. Trustable data at lightning speed -- Learn more at binderverse.rootpath.com

Meet the winners! Based on expert review and social media impact, the five winners of the 1st cycle of Megabase Spark to receive 100 kb of rBlocks™ synthetic DNA are: 🏆 @mcrae_ewan (Houston Methodist) 🏆 Scott Pownall (Open Science Network Society) 🏆 @theicechol (Institute for Medical Engineering and Science, MIT) 🏆 @HansGerstmans (VIB - KU Leuven) 🏆 Hanne Vande Capelle (VIB - KU Leuven) We are inspired by the creativity and ambition of all applicants. Thank you all for submitting your awesome ideas! A huge thank you also goes to our reviewers @ProfTomEllis, @ATinyGreenCell, @timlu and @lecong for lending their expertise and time to evaluate submissions with such rigor. Stay tuned -- cycle 2 of Megabase Spark will open soon!

We are excited to share another #MegabaseSpark submission, titled 'Bio-Based Petrochemicals' from @sean_wirt: "We plan to survey enzymes for activity on non-native substrates, enabling the construction of novel metabolic pathways for bio-based commodity chemicals traditionally derived from petroleum. This research supports the transition to a robust bioeconomy." Like and repost if you think this idea is interesting! #SynBio #SyntheticBiology #DNA

We are excited to share another #MegabaseSpark submission, from @ChrisBatianis: "We wire cell growth to enzyme function: if the enzyme fires, the cell thrives. Thousands of variants turn growth into activity data that train LLM models to design better proteins. Synthesised AI-guided hits push sustainable manufacturing forward." Like and repost if you think this idea is interesting! #SynBio #SyntheticBiology #DNA

We are excited to share another #MegabaseSpark submission, from @nehastar03: "We bioengineer microbial biosynthetic gene clusters (BGCs) to unlock cryptic pathways and discover novel antimicrobial compounds. Using heterologous expression and rational design, we aim to produce potent and structurally diverse bioactive metabolites." Like and repost if you think this idea is interesting! #SynBio #SyntheticBiology #DNA

We are excited to share another #MegabaseSpark submission, from @AmodRBhat: "Tick-borne flaviviruses are stealthy, neglected threats endemic to me but ignored globally. Tired of watching research stall behind biosafety barriers, I intend to engineer "MiniFlaviReps" that are replication competent VLPs but don't require hazmat suits to conduct research.😁" Like and repost if you think this idea is interesting! #SynBio #SyntheticBiology #DNA

With the deadline approaching, we are excited to share another #MegabaseSpark submission, from @HansGerstmans: "Synthetic refactoring and optimization of a biosynthetic gene cluster encoding a potent anti-breast cancer natural product, to improve potency and production in a breast microbiome-resident bacterium." Like and repost if you like this idea! #SynBio #SyntheticBiology #DNA @KU_Leuven @VIB_microbes

Happy Friday! We got a new #MegabaseSpark submission from @lly_sam1: This research uses synthetic biology to determine if all 20 canonical amino acids are essential for life. By designing and testing proteins with fewer amino acids in bacteria, we aim to uncover fundamental life principles and advance protein design and synthetic biology. #SynBio #SyntheticBiology #DNA Like and repost if you like this idea!