@RobShekoi
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Life is coming from you, not at you. Prev Developmental Bio @Harvard.
Joined May 2022
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Rob Sheko retweeted
Rinad (@rinadwithanr) and I wrote an essay about iron deficiency!
It came out of a broader project we’ve been working on surrounding “low-hanging fruit” in improving general health and wellbeing. The problems we’ll address impact many people and their quality of life. In many cases, they tend to be measurable, treatable, and strangely under-served or neglected by the broader healthcare system.
Iron deficiency really stood out here, particularly in women. It’s incredibly common, can affect how you feel and function well before you’re technically anemic, and yet often isn’t caught because routine bloodwork doesn’t actually measure iron stores. (Lately, we’ve been seeing a lot of discussion re: iron deficiency on Twitter, and I’m glad more people are talking about it!)
We looked at how iron deficiency actually works, why ferritin matters, how prevalent it is, what the evidence says about its effects on fatigue, cognition and physical performance, why it so often goes undetected, and what the evidence says about treatment.
This is the first piece in a larger body of work we’re developing on overlooked-yet-surprisingly-tractable problems in health—particularly in women’s health, longevity, and quality of life. More coming soon!
In the meantime, get your ferritin checked and read what we’ve put together. Substack link below!
And if any of this is an area you’re working on or thinking about, DM me or Rinad—we’d love to discuss :)
Rob Sheko retweeted
We've not understood why SGLT2 drugs (like empagliflozin, Jardiance) have marked protective heart benefit.
Today @ScienceMagazine a mechanism unraveled for improving cardiac metabolism and fuel efficiency
science.org/doi/10.1126/scie…
Rob Sheko retweeted
Careful out there - some accounts are getting phishing attacks asking you to vote for them and you can “conveniently” vote with your X account
(Requiring you to login with your password to a X clone)
Bam, phished, account gone
Stay frosty 🥶 folks
Genetic medicine is creating a whole new frontier for aging interventions. Excited to have coauthored a piece here alongside many of the field's top figures. We cover how gene editing, RNA silencing, epigenome modification, and engineered cell therapies can be used to close fundamental gaps in our biology and address problems no intrinsic pathways can solve.
IT'S OUT. 🎉
FRONTIERS OF LONGEVITY SCIENCE @SpringerNature
Leading scientists, clinicians, and entrepreneurs on where the field stands, and where it will go.
Science today. Longevity tomorrow. 🚀
Like and repost to help it travel!👇👨⚕️
🔗linkedin.com/posts/agingdoc_…
It’s crazy how, just a few years ago, thymic regrowth was a pretty niche area in aging research. Involution was seen as a normal part of immune maturation. Now several groups are going after it. Expecting some big results out of this therapeutic approach
Sustaining the health of the thymus and our immune system, preventing its involution, may be key to promoting healthspan @nature @EdwrdChen
nature.com/articles/d41586-0…
So excited to be expanding Aevitas to NYC! If you're in the area working on aging and regenerative medicine, or just curious about the field, we'd love to hear from you. We're building the NYC community for in-depth conversations about organ rejuvenation, bioengineering, stem cell therapies, and the broader challenges shaping the future of human health.
Aevitas is expanding! We’re so excited to announce Aevitas NYC: a new hub for New York’s aging biology community.
Aging is one of the most complex problems in biology, and large-scale breakthroughs require more than individual labs working in isolation. The field needs spaces for exceptional scientists, clinicians, investors, and founders to share knowledge, challenge assumptions, and build new approaches. That's why we started Aevitas.
After a phenomenal two years with our SF hub, we chose NYC as the place to build our second node. New York is becoming a global powerhouse in tissue regeneration, novel aging clinical trials, and multi-omic systems biology. We believe New York will be a defining center for the next generation of aging science.
So what will Aevitas NYC look like? A dense, technical community where ambitious people can exchange ideas, form collaborations, and work on the foundational challenges of aging and human healthspan. We'll host events at our physical space as well as our resident builders program. If you're interested in being a resident or attending our events, we've linked all the info you need below.
See you in NYC!
Rob Sheko retweeted
Replying to @bryan_johnson
If your "biological age" can leap 13 years and then quickly return back after you've slept, you haven't measured aging, you've measured something more akin to tiredness.
I strongly suspect a key part of treating cellular aging will involve restoring histone production. Expression of histone proteins declines with age and puts cells in a position where they can’t properly maintain nucleosomes/chromatin/epigenetic regulation, both at baseline and especially during cell division.
I’m excited to launch the Longevity Biotech Atlas, a personal project mapping 700+ organizations across the aging and longevity ecosystem.
Longevity biotech is moving fast.
A lot of the public narrative has centered on GLP-1s, peptides, biohacking, and consumer health optimization. But beneath that, a much deeper ecosystem is forming: companies, labs, investors, and non-profits working on core technologies that will enable fundamentally new forms of measurement and rejuvenation.
The field is growing quickly, but it is still hard to answer basic questions:
Who is building what?
Which areas are crowded?
Which technologies are underexplored?
Where should founders, scientists, investors, and operators be paying attention?
To help make the space easier to navigate, I synthesized public information on 700+ organizations—ranging from therapeutics developers, diagnostics, investors, and more— into a single database.
You can explore the atlas at the link in the comments.
This is still an early version, and I’ll be adding more over time: new organizations, personal accounts, bookmarks, and better ways to track how the field is evolving. My hope is to build this out into a core tool for people trying to understand, build, fund, or work in longevity.
If you’re interested in aging biology, biotech, investing, company formation, or the future of medicine, follow along. I’ll be sharing updates, maps of different subfields, and analyses of where the biggest opportunities and gaps may be. Let me know what you find useful!
Vitalist bay was a phenomenal experience last year! If you’re at all interested in aging this is the event you need to go to!
Rob Sheko retweeted
Big takeaway from looking through all the events: longevity, AI, and women's health are hot🔥. ARPA-H, the US govt's new $1.5bil/year granting agency, is on the ground at JPM looking for innovators shaping biotech's future. Lots of exciting events, see you all there! --Aevitas
What happens if you combine the TRIIM trial intervention with the recent DFI treatment Feng Zhang published? Both boosted different aspects of adaptive immune development and maintenance. The next step is clearly to put the two together!
One year down, and what a journey its been! @AevitasHouse has been an incredible community of researchers and builders solving urgent challenges in human health. For 2026, we're expanding our support of projects in aging, bioengineering, and systems biology. Especially if you're early stage or new to SF, we'll help you find the right people and supporters for your project. If you've been looking for a hardcore, technical biotech community to call home, apply for our 2026 cohort!