@RicciLab
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Professor @ Univ. of Rome Tor Vergata. #Nanotechnology, #SyntheticBiology, #Nanomachines and #Nanodevices.
Roma, Lazio
Joined May 2017
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Francesco Ricci Lab retweeted
Immune-Induced Antibody–DNA Hybrid Condensates | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
New paper from our group just out in @J_A_C_S! We show the combined use of DNA-DNA and antibody–antigen interactions to induce phase separation of antibody–DNA hybrid condensates. pubs.acs.org/doi/10.1021/jac… Congrats to Sara (@sara29_ss) for her first first-author paper!👇🧵 1/n
We also show that by simply replacing the antigen on the DNA nanostar we can induce the phase separation of different condensates in a orthogonal way without any crosstalk...here is the microscopy image of three condensates formed upon addition of three different antibodies! 5/n
All results were nicely described by theory and simulations of a phase-field model by our collaborators Lorenzo Rovigatti and Marco Cappa @SapienzaRoma. Finally thanks to co-corresp author
@erica_delgrosso for her invaluable support and @AIRC_it and @ERC_Research for funding. 6/n
The next Functional DNA Nanotechnology workshop #FDN2025 (Rome 15-17 October) is just around the corner! Due to last minute cancellations, we still have a couple of places available if anyone is interested... fdn2025.com/
Nice to see this collaborative work out in @angew_chem. We joined forces with @Ale_Sorrenti1 and @PuigmartiLuis to achieve non-equilibrium steady states using DNA-based systems and controlled RNA fuel supply. Congrats to @erica_delgrosso and @JamesDNicholas🥳
📢Check out our new paper! ✨
We demonstrate non-equilibrium steady states of a DNA-based system that dynamically adapt in real-time to subtle on-the-fly variations of a RNA fuel supply, and correspond to a true non-equilibrium composition of the system.
doi.org/10.1002/anie.2025129…
Francesco Ricci Lab retweeted
Excited to see our latest work finally out in @NatureNano 😍😍. Great collaboration and many thanks to all the authors @leonard_prins @RicciLab @benjamino_acid and @Epenocchio 🥳🥳
New paper online:
An information ratchet improves selectivity in molecular recognition under non-equilibrium conditions.
"...mechanism increases selectivity for the correct DNA duplex from 2:1 at equilibrium to 6:1 under energy-dissipating conditions."
nature.com/articles/s41565-0…
Great to see this is now out in @NatureNano! Thanks to @leonard_prins for this (yet another) collaborative project...kudos to @erica_delgrosso and Ben Roberts for combining experiment and theory in such a nice way. Thanks also to @EPenocchio for help with the theoretical part!
New paper online:
An information ratchet improves selectivity in molecular recognition under non-equilibrium conditions.
"...mechanism increases selectivity for the correct DNA duplex from 2:1 at equilibrium to 6:1 under energy-dissipating conditions."
nature.com/articles/s41565-0…
Hurry up! Today is the deadline to submit an abstract for the next Functional DNA Nanotechnology workshop #FDN2025, Rome 15-17 October 2025! Co-organized with Tim Liedl (@CeNS_LMU) and Fritz Simmel. fdn2025.com
The paper describing our MAIGRET (Molecular Assay based on antibody-Induced Guide-RNA Enzymatic Transcription) system is finally out in @NAR_Open! academic.oup.com/nar/article…. @ERC_Research, @AIRC_it 1/n
The name of the assay is an homage to one of the best examples of CRISPR-based sensors (SHERLOCK,
@Sherlock_Bio) developed by @zhangf, Collins + colleagues. While SHERLOCK detects DNA/RNA strands, MAIGRET enables the detection of proteins, antibodies and other molecules. 5/n
Finally, big congrats to our PhD student Francesca Miceli for her first first-author paper and to all the coauthors (@Simona_Ranallo, @BracagliaSara, @SorrentinoDa, @alessan_porch).
Francesco Ricci Lab retweeted
*ALERT*
If you are a bioengineer (or related), if you use synthetic biology for health-related applications, and you wish to start your own lab in a neat place (Naples), in a fantastic research institute, stay tuned, a call will be coming out! DM me if you want to have more info!