Research Leader Computational Biology @DEECA_Vic @VicGovAg | visiting researcher @CamBakerSGI | @BakerResearchAu | @UniMelb | Views my own
Melbourne, Victoria
Joined October 2019
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A layman digest of our recent paper “Integrating extensive functional annotations and multiomics of cattle enhances climate resilience prediction and mapping” link.growkudos.com/1etkb99p4…
Massive multi-omics data are generated to annotate animal genomes. However, how to use these datasets to improve genomic prediction and mapping is not clear. More importantly, how to use these datasets to improve agriculture in the changing climate is not understood.
Integrating extensive functional annotations and multiomics of cattle enhances climate resilience prediction and mapping | PNAS pnas.org/doi/10.1073/pnas.25…
Integrating extensive functional annotations and multiomics of cattle enhances climate resilience prediction and mapping | PNAS pnas.org/doi/10.1073/pnas.25…
Ruidong Xiang retweeted
GSOR is validated by applying it to milk lipid traits in cattle, led by Ghoreishifar et al, and they identify potentially causal genes and pathways linked to milk composition: lnkd.in/gUyqvtG9
Estimated Breeding Value(EBV) or Polygenic Score(PGS) cal using genome-wide SNPs. We propose calculate EBV or PGS near genes - cis or local EBV/PGS to assoc with assayed gene expression to prioritise genes and tissues: Genetic score omics regression (GSOR)academic.oup.com/pnasnexus/a…
GSOR is validated by applying it to milk lipid traits in cattle, led by Ghoreishifar et al, and they identify potentially causal genes and pathways linked to milk composition: lnkd.in/gUyqvtG9
Ruidong Xiang retweeted
Estimated Breeding Value(EBV) or Polygenic Score(PGS) cal using genome-wide SNPs. We propose calculate EBV or PGS near genes - cis or local EBV/PGS to assoc with assayed gene expression to prioritise genes and tissues: Genetic score omics regression (GSOR)academic.oup.com/pnasnexus/a…
Ruidong Xiang retweeted
We collaborated on analysing MRI imaging data from the UK Biobank, found that visceral adipose tissue (abdominal fat) has stronger links to venous thromboembolism (blood clot) than BMI. Publication: sciencedirect.com/science/ar…
We collaborated on analysing MRI imaging data from the UK Biobank, found that visceral adipose tissue (abdominal fat) has stronger links to venous thromboembolism (blood clot) than BMI. Publication: sciencedirect.com/science/ar…
Ruidong Xiang retweeted
Complex trait analyses usually focus on trait means. We analysed trait variances in human blood cell phenotypes, yielding new biological/clinical insights: trait variation strongly negatively selected, impact polygenic score accuracy and highlights the effect of alcohol on health
Ruidong Xiang retweeted
Further reading: Further reading: nature.com/articles/s41467-0…
Complex trait analyses usually focus on trait means. We analysed trait variances in human blood cell phenotypes, yielding new biological/clinical insights: trait variation strongly negatively selected, impact polygenic score accuracy and highlights the effect of alcohol on health
Further reading: Further reading: nature.com/articles/s41467-0…
Ruidong Xiang retweeted
Thrilled to share that the pilot ChickenGTEx resource is online at Nature Genetics now @NatureGenet . Congratulations to all the collaborators. Looking forward to more scientific outcomes from the FarmGTEx. nature.com/articles/s41588-0…
Ruidong Xiang retweeted
Exciting global efforts to discover and use regulatory variants (eg, eQTLs, sQTLs) to enhance agriculture, evolution and biomedicine! Further reading for our pioneer work in Cattle GTEx: resource 👉nature.com/articles/s41588-0…; trait heritability dissection 👉sciencedirect.com/science/ar…
Thrilled to share that The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project perspective paper is out @NatureGenet. Thank all the authors for the efforts and supports. Looking forward to seeing amazing science coming from this initiative. nature.com/articles/s41588-0…
Exciting global efforts to discover and use regulatory variants (eg, eQTLs, sQTLs) to enhance agriculture, evolution and biomedicine! Further reading for our pioneer work in Cattle GTEx: resource 👉nature.com/articles/s41588-0…; trait heritability dissection 👉sciencedirect.com/science/ar…
Thrilled to share that The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project perspective paper is out @NatureGenet. Thank all the authors for the efforts and supports. Looking forward to seeing amazing science coming from this initiative. nature.com/articles/s41588-0…
Ruidong Xiang retweeted
Great to see the Farm Animal Genotype–Tissue Expression (#FarmGTEx) Project perspective article published in @NatureGenet. A fantastic #livestock #FunctionalGenomics project led by @LingzhaoF at @AarhusUni_int.
nature.com/articles/s41588-0…
Ruidong Xiang retweeted
Thrilled to share that The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project perspective paper is out @NatureGenet. Thank all the authors for the efforts and supports. Looking forward to seeing amazing science coming from this initiative. nature.com/articles/s41588-0…
One of it’s kind: sheep multi-tissue developmental gene expression atlas (dGEA) academic.oup.com/gpb/article… ; global collaboration across EU, China, Australia and US! @emilylouise221 @LingzhaoF