mRNA translation and degradation group leader in Bern, viral proteins vs human translation - Nanopore seq-curious and very much into teaching - 🏳️🌈
Bern, Switzerland
Joined May 2014
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We report a human cell-free translation screen that identified NT-2, a Fusarium mycotoxin that blocks human ribosomes.
The surprise: NT-2 does binds the ribosome and pushes them into a dormant state. #ribosome #RNA #cryoEM
nature.com/articles/s42003-0…
Some of our research highlights featured in @Nature
@unibern @MCIDBern @DCBPunibern
nature.com/articles/d41586-0…
Karousis Lab retweeted
Our latest work is out in @Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 nature.com/articles/s41586-0…
New pre-print 📢:Cell-free translation from diverse human cell types: Fast, reproducible and scalable @JZiegelmuller @OMuhlemann @MCIDBern @DCBPunibern @unibern biorxiv.org/content/10.1101/… – at Berne, Switzerland
#Habilitation done! 🎉 I’m grateful and proud to receive the Privat Dozent title from @unibern, an institution with a special place in my heart. I'll strive to stand as an ambassador of its values in sharing my passion for Biochemistry and Molecular Biology. @DCBPunibern
1/ Preprint alert📢: Uncoupling the functional roles of Coronavirus Nsp1
biorxiv.org/cgi/content/shor… #biorxiv_molbio
Doubly excited because this work is based on our first Master's student to graduate from the lab, Emilie Bäumlin.
@unibern @DCBPunibern @MCIDBern @NCCR_RNADisease
5/ We evaluated Nsp1 previously proposed Nsp1 inhibitors, Montelukast and Mitoxantrone, finding them ineffective against Nsp1’s ability to inhibit translation. 🚫
Thrilled to see @Jonathan_Bohlen, starting his group, very, very well deserved!
It's a very special day for me. I am so excited and grateful for this opportunity. My lab will study the role of mRNA translation in human immunity. Reach out if you're interested to join us. @GeneCenter_LMU @LMU_Muenchen
Karousis Lab retweeted
Please RT: Are you a highly skilled, top-motivated biochemist looking for an exciting postdoc project? We are looking for you. For details, check here: ohws.prospective.ch/public/v…
Is Science Direct down for everyone? Any ideas how to circumvent it when doing doi-based paper searches?
#sciencedirect #AcademicTwitter #AcademicChatter
Karousis Lab retweeted
Today we report in @natBME the eePASSIGE system, which uses evolved and engineered recombinases and prime editing to integrate large gene-sized DNA cargoes into the mammalian genome in an efficient, precise, and targeted manner. (1/13)
drive.google.com/file/d/1WDM…
Karousis Lab retweeted
We’re excited to share our study in @CellCellPress on the role of the MAP3 kinase ZAK in UV-induced apoptosis led by @2primehydroxyl! We studied cell signaling kinetics following UV-damage and found that ZAK drives apoptosis via ribosome collisions. cell.com/cell/fulltext/S0092…
Karousis Lab retweeted
Check out our two new papers! We delevoped a method to follow individual translating ribosomes for hours in living cells, and discovered that ribosomes are great friends and help each other in problematic situations
Two new lab papers: In the first paper we develop Stopless-ORF circRNAs (socRNAs), a technique to measure translation by individual ribosomes with incredible precision. Amazing work jointly led by @MadernMax and @_SoraY.
biorxiv.org/content/10.1101/…
Karousis Lab retweeted
Our work on translation-dependent mRNA decay during T CD4+ lymphocyte activation is out! @genomeresearch genome.cshlp.org/cgi/content…