Group leader at Netherlands Cancer Institute / Quantitative Systems Biology
Nederland
Joined September 2011
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Exciting news for aspiring PhD students: the NKI PhD Program 2025 will open soon for applications! We participate with multiple top labs in this prestigious program, which offers a unique opportunity for PhD candidates to engage in cutting-edge genome biology and cancer research.
📢 Applications for the NKI PhD program open from Jan 1 - Feb 28. Join our international research community in Amsterdam, working in cancer biology, AI research & life sciences with leading scientists and top facilities #PhD #CancerResearch More info: bit.ly/3O4bOjq
Passionate about doing innovative, curiosity-driven research and looking to start your own lab? The NKI has an opening for a Junior Group Leader position! Join us in our collaborative environment in Amsterdam, to use our state-of-the-art infrastructure to make a real impact.
👀 We're looking for a junior group leader! Join our innovative, curiosity-driven institute in a collaborative, international environment. Full freedom to pursue your research, competitive salary & relocation support.
📅 Apply by Dec 1
Info & application: bit.ly/3BLA3j8
Happy and proud to receive the ERC Starting grant! We will investigate how genome-wide binding kinetics and energy landscapes of oncogenic transcription factors are regulated!
Interested in joining our team? Apply before the 22th of Sept. #ERCStG
nki.nl/news-events/news/euro…
Excited to share that we received the Technology Impact Award from @CancerResearch to develop methods to study immune - cancer cell interactions for identifying proteins and antigens that modulate cancer cell killing, and targets for immunotherapy! cancerresearch.org/cri-funde…
I'm #hiring a PhD student! Join the Lindeboom Lab at the @NKI_nl on an exciting project to explore oncogenic transcription factor binding kinetics and biophysics using state-of-the-art technologies! Apply now or share this exciting opportunity! nki.nl/careers-study/vacanci…
Extremely excited to see our paper out in @Nature!
How does the body respond to SARS-CoV-2, and what happens if you don't get infected after exposure?
We unravel the exact timeline of the cellular responses to inoculation with SARS-CoV-2 in humans. (1/4) nature.com/articles/s41586-0…
Highlights include the unexpected timing of the interferon response, new innate responses in unexpected cells and in abortive infections, identification and application of new activated T cell populations, and lower HLA-DQA2 expression as predictor for sustained infections. (3/4)
This was an amazing team effort by the @Teichlab and @drmarkonikolic lab. Massive thanks to my partners in crime @WorlockKaylee and Lisa Dratva, the @ChrisChiuLab that established the model, the involved teams at @sangerinstitute, @ucl, @NKI_nl, @imperialcollege, @hVIVO_UK. (4/4)
I'm #hiring a #postdoc to join my research group at the NKI in Amsterdam. Are you interested in developing state-of-the-art genomics and proteomics technologies to study TCR : antigen interactions in cancer? Apply before the 8th of May: nki.nl/careers-study/vacanci…
#AcademicTwitter
Honored to be among the recipients of the NWO Open Competition M1 grant! We will develop tools to improve our understanding of TCR-antigen interactions, using high-throughput screening & AI. Stay tuned for a postdoc vacancy to join this exciting project!
nwo.nl/en/news/nineteen-inno…
Rik Lindeboom retweeted
Nature research paper: Decoding chromatin states by proteomic profiling of nucleosome readers go.nature.com/3P7kNRC
Stoked to see this tour-the-force from the Bartke team out in Nature! We've decoded how DNA & histone modifications regulate protein binding to the genome using quantitative interaction proteomics. A leap forward in understanding chromatin dynamics! Congrats to everyone involved!
“If you want to know someone, look at their friends…” that’s how we decode histone codes and chromatin states.
Finally, the dream has come true… Almost a decade after I started the project in London, it has been published on Nature.
Enjoy the paper: nature.com/articles/s41586-0…
Thrilled to share my journey as a new junior PI at @NKI_nl, featured in @NatureCancer. From overcoming the challenges of setting up a lab to building a team and plotting a scientific course.
💫ONLINE NOW @NatureCancer – the #2023Generation – 12 group leaders share their journey to becoming an independent PI. Very inspiring stories, please do not miss them!
nature.com/articles/s43018-0…
Rik Lindeboom retweeted
Congratulations to Piet Borst, 2023 #LaskerAward winner! – “for an exceptional 50-year career of scientific discovery, mentorship, and leadership”. ow.ly/cuFl50PNTMJ
#Lasker2023 #LaskerLaureate #mtDNA #mitochondria #trypanosomes
The NKI opened an exciting new call and PhD program for students interested in Chromosome Biology and Gene Regulation!
🎓We are looking for outstanding candidates who want to become the new generation of ambitious #PhDstudents in a lively international research community. Check our website to learn about our #PhDprogram in #ChromosomeBiology & #GeneRegulation
➡️bit.ly/44iOcOc
Rik Lindeboom retweeted
Do different host transcriptional biomarkers of acute viral infection offer different clinical and research applications? Insights from SARS-CoV-2 human challenge in our new PREPRINT: medrxiv.org/content/10.1101/…
Rik Lindeboom retweeted
Excited to share STAPLER, a language model to predict TCR – pMHC reactivity that outperforms prior models.
And for ML aficionados: Description of a new data leakage problem inherent to a common negative data generation strategy.
biorxiv.org/content/10.1101/…
🧵👇
Rik Lindeboom retweeted
Our pre-print is out!!
Proud to share our work as part of the world’s first human #COVID-19 challenge study, in which we looked to temporally resolve the epithelial and immune response in SARS-CoV-2 infections at the single-cell level. 🧬🦠🔬
Key highlights summarised👇🧵(1/6)
Preprint alert! Excited and proud to share our work in which we applied single cell multi-omics on a unique-in-the-world SARS-CoV-2 challenge model to resolve the local and systemic immune response to an exact dose of virions in humans over time. (1/6) medrxiv.org/content/10.1101/…
We also provided multiple community resources. You can browse our sc data via our web portal, use Cell2TCR to identify activated TCRs in any dataset, and we provide models for detailed cell state annotation and to infer time since viral exposure in patient samples. (5/6)
An amazing team effort by the @Teichlab and @drmarkonikolic lab, especially my partners in crime @WorlockKaylee and Lisa Dratva, and @ChrisChiuLab for establishing the model. With teams from @sangerinstitute, @ucl, @imperialcollege, @hVIVO_UK. Thanks to everyone involved! (6/6)