Mach Lab (@RHMachLab) profile picture

Mach Lab

@RHMachLab

Laboratory of Robert H Mach

 University of Pennsylvania
med.upenn.edu/apps/faculty/index.php/g275/p8658246
Joined April 2020
  • Tweets19
  • Following36
  • Followers62
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Photo by Mach Lab (@RHMachLab)
Exciting work from our lab on computer-aided drug design for radio-tracer development titled “Computational Chemistry for the Identification of Lead Compounds for Radiotracer Development” has been recently published in Pharmaceuticals mdpi.com/1424-8247/16/2/317
Computational Chemistry for the Identification of Lead Compounds for Radiotracer Development

Computational Chemistry for the Identification of Lead Compounds for Radiotracer Development

The use of computer-aided drug design (CADD) for the identification of lead compounds in radiotracer development is steadily increasing. Traditional CADD methods, such as structure-based and ligand...

mdpi.com
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Mach lab and friends at the ⁦@UofPenn game! ⁦@aladdinBro @TaraTaghvaee @GuilongT⁩ @ChemistryGrEEK @rickbarrett_phd @air_sea_sam⁩
Image from Mach Lab (@RHMachLab)
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Poly (ADP-ribose) (PAR) is reported to interact with phosphorylated α-Synuclein in post mortem #Parkinsons samples - from @RHMachLab & colleagues; Interactions between negatively charged PAR & lysine residues on the N-terminal region of αSyn confirmed frontiersin.org/articles/10.…
Image from The Science of Parkinson's (@ScienceofPD)
Image from The Science of Parkinson's (@ScienceofPD)
Image from The Science of Parkinson's (@ScienceofPD)
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Replying to @Scott_LabUM @SocRadiophSci
Thank you @Scott_LabUM it was a great conference with a lot of exciting research!
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New evaluation of a low-toxicity PARP inhibitors as a neuroprotective agents for #Parkinsons from @RHMachLab; The ideal PARP inhibitor needs to inhibit PARP-1 hyperactivity while also limiting downstream DNA damage & cellular toxicity (ideal for oncology) link.springer.com/article/10…
Image from The Science of Parkinson's (@ScienceofPD)
Image from The Science of Parkinson's (@ScienceofPD)
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Just realized our friends from @RHMachLab at @PennRadiology are on the Twitter! Show them some love!
Image from ScottLab (@Scott_LabUM)
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Proof-of-concept study demonstrates new approach for identifying #PET tracers for Parkinson’s & other neurodegenerative diseases🧠 ft Virginia Lee (@PennPathLabMed), @RHMachLab, Zsofia Lengyel-Zhand (@PennRadiology), @EJPLab & John Ferrie (@PennChemistry) bit.ly/33MngIT
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Our review @RHMachLab @WindhorstBert featured by @Molecules_MDPI !
Molecules MDPI (@Molecules_MDPI) profile pictureMolecules MDPI@Molecules_MDPI11 Aug 2020
#HighlyCitedPaper #HighlyAccessedPaper PET Imaging of Microglial Activation—Beyond Targeting TSPO By Robert H. Mach, et al. 👉mdpi.com/1420-3049/23/3/607 #positronemissiontomography #microglia #neuroinflammation
Image from Molecules MDPI (@Molecules_MDPI)
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Check out our recently accepted manuscript 📝 in @ChemCommun Synthesis and Characterization of High Affinity Fluorogenic α-Synuclein Probes 🔗 pubs.rsc.org/en/content/arti…
Synthesis and characterization of high affinity fluorogenic α-synuclein probes†

Synthesis and characterization of high affinity fluorogenic α-synuclein probes†

Fluorescent small molecules are powerful tools for imaging α-synuclein pathology in vitro and in vivo. In this work, we explore benzofuranone as a potentia

pubs.rsc.org
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The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor complex are responsible for the cellular uptake of Aβ42 and its protein aggregates biorxiv.org/cgi/content/shor… #bioRxiv
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The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor complex are responsible for the cellular uptake of Aβ42 and its protein aggregates biorxiv.org/cgi/content/shor… #biorxiv_neursci
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PARP-1 tracer demonstrates that PARP-1 expression is independent of breast cancer subtype providing foundational evidence to test PARP PET as a companion diagnostic for PARP inhibitor therapy jamanetwork.altmetric.com/de…
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RT @PennRadiology PARP-1 tracer demonstrates that PARP-1 expression is independent of breast cancer subtype providing foundational evidence to test PARP PET as a companion diagnostic for PARP inhibitor therapy jamanetwork.altmetric.com/de…
Penn Radiology (@PennRadiology) profile picturePenn Radiology@PennRadiology16 Apr 2020
Great @PennMedicine team effort on clinical trial shows PARP-1 expression is independent of breast cancer subtype providing foundational evidence to test PARP PET as a companion diagnostic for PARP inhibitor therapy jamanetwork.com/journals/jam… #PARP1 #breastcancer @PennMDForum
PET Imaging of Poly–(Adenosine Diphosphate–Ribose) Polymerase 1 Expression in Breast Cancer

PET Imaging of Poly–(Adenosine Diphosphate–Ribose) Polymerase 1 Expression in Breast Cancer

This nonrandomized clinical trial tested [18F]FluorThanatrace as a method for measuring regional poly–(adenosine diphosphate–ribose) polymerase 1 expression in breast cancer and as a potential...

jamanetwork.com
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Great @PennMedicine team effort on clinical trial shows PARP-1 expression is independent of breast cancer subtype providing foundational evidence to test PARP PET as a companion diagnostic for PARP inhibitor therapy jamanetwork.com/journals/jam… #PARP1 #breastcancer @PennMDForum
PET Imaging of Poly–(Adenosine Diphosphate–Ribose) Polymerase 1 Expression in Breast Cancer

PET Imaging of Poly–(Adenosine Diphosphate–Ribose) Polymerase 1 Expression in Breast Cancer

This nonrandomized clinical trial tested [18F]FluorThanatrace as a method for measuring regional poly–(adenosine diphosphate–ribose) polymerase 1 expression in breast cancer and as a potential...

jamanetwork.com
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