The Research Center for Clinical Neuroimmunology and Neuroscience Basel is an interdisciplinary research institution supported by a non-profit foundation.

Basel
Joined February 2022
RC2NB retweeted
Yes👍 from @SofiaSandgren1 @JensKuhle @RC2NB @UniBasel: Blood NfL can provide information on disease activity, prognosis and treatment response, both in drug development trials and in personalised medicine in #MultipleSclerosis. 🔽 journals.sagepub.com/doi/abs… 2/🧵
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RC2NB retweeted
In #MultipleSclerosis, treatment effects on blood neurofilament light chain #NfL are moderately associated with therapeutic effects on relapses and MRI lesions. A meta-regression of randomized controlled trials from @RC2NB @UniBasel_en @unige_en ▶️ journals.sagepub.com/doi/abs…
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RC2NB retweeted
OCT availability and routine use by neurologists is limited in Switzerland. Awareness, education and guidelines on its clinical use in the care of people with #MultipleSclerosis. 🔓MSJ-ETC study from @Unispital_USZ @RC2NB ▶️ journals.sagepub.com/doi/ful…
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RC2NB retweeted
Deep learning can automate the classification of paramagnetic rim and remyelinated lesions in #MultipleSclerosis, guiding personalized treatment decisions. Study from @CristinaGranzi2 @RC2NB ▶️ journals.sagepub.com/doi/abs…
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New study in Science Translational Medicine (@ScienceMagazine) from @akproebstel and colleagues reveals distinct immune signatures in MOG antibody–associated disease (MOGAD), distinguishing it from MS. Researchers from Zurich, Munich, Toulouse, Lyon, Bonn & Basel (@DepBiomedicine, @DKFBasel, @RC2NB) uncover key immune differences shaping future therapies. 👉🏻 Link: science.org/doi/10.1126/scit… #MOGAD #MSResearch #Neuroinflammation
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MSIF is proud to announce Professor Ludwig Kappos as the 2025 #CharcotAward recipient, honouring a lifetime of impact in #MSResearch. 🏆🔬 From pioneering treatments to mentoring researchers worldwide, his legacy is global. 🌎 Read more: msintfederation.org/4ncra5K   @RC2NB
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Functional System scores and their corresponding subscores, Ambulation scores and EDSS scores revealed different patterns of disability in #MultipleSclerosis. Machine learning study using EXPAND trial from @RC2NB @UniBasel_en @UniSpitalBasel ▶️ journals.sagepub.com/doi/ful…
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Just 24 participants to go: Our Swisswide pragmatic #MultiSCRIPT trial is close to reaching 915 in about a year. Only possible through full embedding in routine care and with an outstanding team @RC2NB and #SMC and the wonderful support of our patients. multiscript.rc2nb.ch/
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Authors developed and validated SMARTCARE-EDSS training method to enable health care professionals to assess disability for decentralized trials in #MultipleSclerosis. A Swiss multicenter, randomized, cross-over study from @UniSpitalBasel @RC2NB ▶️ journals.sagepub.com/doi/ful…
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"[R]epair and damage processes within [#MultipleSclerosis] #lesions occur across the entire disease spectrum and their frequency correlates with patient disability, age, disease duration, and extent of neuroaxonal damage." doi.org/10.1002/ana.27102 @ThINk_Basel @RC2NB
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A hearty congratulations to the following new ECTRIMS Executive Committee members: Prof Gabriel Bsteh from @MedUni_Wien, Prof @J_SastreGarriga from @cemcat_em, and Prof @ZippFrauke from @uni_mainz More governance updates to follow! ➡️ bit.ly/3XWAmR7 #ECTRIMS2024
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Great to see #MultiSCRIPT highlighted @ECTRIMS. We @RC2NB hope this will be the future of real world evidence in MS.
Exciting news from the MultiSCRIPT Trial! We've hit 40% of our target with 373 participants. Welcome to Inselspital & Zurich University Hospital! Huge thanks to our dedicated team and participants. Learn more here: multiscript.rc2nb.ch/
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REFLEX study: Higher baseline #sNfL levels were associated with increased risk of conversion to #MultipleSclerosis, while treatment with sc #interferon β-1a delayed conversion time. doi.org/10.1177/175628642412… @JensKuhle @RC2NB
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New clue in MS brain protection: B cell therapy & a molecule called BAFF might work together to safeguard brain tissue. #MSresearch #Bcelltherapy #neuroprotection #MSresearch #BAFF (@proebstellab , Universities of Toronto, Mainz & Basel) Link Publication: science.org/doi/10.1126/scit… @ScienceTM
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There are 48 pragmatic trials 1967–2022 to assess mostly supportive care in #MultipleSclerosis (85%), with only 7 evaluating drugs (15%). New potential for randomized real-world evidence? A systematic overview from @LGHemkens @RC2NB @UniBasel ▶️ journals.sagepub.com/doi/ful…
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Central vein sign and cortical lesions may be valuable tools to increase the accuracy of multiple sclerosis diagnosis. ja.ma/3uWSw9d
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Studien mit Patienten sind wertvoll für die Erforschung neuer Therapien – aber nur, wenn sie einem festgelegten Schema folgen. Doch deutsche Unis biegen sich dieses Schema häufig zurecht, wie eine Analyse aus #PlosMedicine zeigt. Mit @m_grill via @SZ sz.de/1.6302964
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