Changes in metabolic pathways are frequently seen in cancer cells, and mutations in certain metabolic genes may even play a direct role in cancer development and progression. One gene for which this is true is the multi-localizing gene FH. proteinatlas.org/news/2026-0…

The protein FATE1 is abnormally expressed in many cancer types and using mIHC/IF it is shown to localize (green) to the cytoplasm (red) and nucleus (magenta) of Sertoli cells that support the developing sperm cells in testis. proteinatlas.org/news/2026-0…

The expression of PDX1, the transcription factor regulating development of the pancreas and expression of insulin in beta cells in the islets of Langerhans, is shown to localize (green) to the nucleus of beta cells (magenta) using mIHC/IF. proteinatlas.org/news/2026-0…

Current therapies inadequately target T-cell pathways in autoimmune and inflammatory diseases limiting disease control. In a recent publication a novel, targetable transcriptional-metabolic axis that sustains inflammatory T-cell responses is identified. proteinatlas.org/news/2026-0…

A Protein Sci article presents the HPA Multiplex tissue resource, with 1,106 proteins analyzed across eight antibody panels. Mapping proteins to cell types, cell states, and tissue structures give deeper insights in protein expression in human tissues. proteinatlas.org/news/2026-0…

A protein in the wrong place can be catastrophic ALS is associated with high morbidity and early mortality. It has turned out that redistribution of the protein TARDBP from the nucleus to the cytoplasm in multiple brain cell types is part of the process. proteinatlas.org/news/2026-0…

A recent study investigated early changes in ovarian cancer. In this interview Fabian Coscia and Mihnea-Paul Dragomir discuss how the team moved from spatial proteomics discovery to tissue-based validation using an antibody against DHCR7. proteinatlas.org/news/2026-0…

A study in PNAS describes how hypoxia and elimination of peroxisomes drives HCC dedifferentiation. RNF126 is identified as an inducible switch that determines peroxisomal fate and links the hypoxic microenvironment to loss of hepatocyte differentiation. proteinatlas.org/news/2026-0…

Saliva is a combination of enzyme-rich secretions from serous acini and mucin-rich secretions from mucus acini. Using mIHC/IF the regulator of acinar cell functions BHLHA15 (green) is shown in the nucleus of serous acini (cyan) within the salivary gland. proteinatlas.org/news/2026-0…

Mitochondria go where they are needed Mitochondria do a lot more than ATP production. The positioning of mitochondria within cells is regulated and dynamic and their direct interaction with other organelles can regulate many cellular processes. Read more proteinatlas.org/news/2026-0…

Transcription factor FOXJ1 (magenta) and chromatin regulator HMGN3 (green) display different nuclear staining in the fallopian tube. FOXJ1 stains a subset of the cells in the fallopian tube epithelium while HMGN3 shows a more general staining pattern. proteinatlas.org/news/2026-0…

A Nature study suggests ALDH18A1 and ferroptosis as a therapeutic target for cancer treatment. Inhibition of ALDH18A1 suppressed livercarcinogenesis through depletion of spermine (essential for cellular homeostasis) and activation of ferroptosis in HCC. proteinatlas.org/news/2026-0…

In this episode of Proteins Unfolded Evelina Sjöstedt, head of HPA Single cell analysis talks about the transcriptome in the context of the genome and proteome. She discusses her current research at The Human Protein Atlas and single cell transcriptomics. proteinatlas.org/news/2026-0…

In the Episode 82 of of the Proteomics show podcast series "Alt Proteomics" HPA researcher Dr Cecilia Lindskog talks about the importance of proteomics data integration together with the hosts Benjamin Neely and Ben Orsburn. proteinatlas.org/news/2026-0…

Glycolysis-associated enzyme PKLR highlighted in cytoplasm of proximal tubular cells (green) in the kidney using multiplex immunohistochemistry. Other kidney structures shown are Distal tubules (red), podocytes (yellow) and endothelial cells (magenta). proteinatlas.org/news/2026-0…

In version 25.1 of the Human Protein Atlas, a dataset based on Deep Visual Proteomics has been integrated in the Single Cell resource to provide mass-spectrometry based proteomics at an unprecedented resolution across cell types and tissues. proteinatlas.org/news/2026-0…

A study by HPA researchers in Nature Communications presents a high-resolution spatial map of proteins associated with motile cilia in the human fallopian tube, providing new insights into reproductive biology, infertility and cilia-related disease. proteinatlas.org/news/2026-0…

The Human Protein Atlas welcomes GeneTex’s recent announcement formalizing a collaborative relationship with the Human Protein Atlas. Collaborations with Atlas Antibodies, NCI-CPTC, Thermo Fisher Scientific, and Absea Biotech are also acknowledged. proteinatlas.org/news/2026-0…

The differences in blood protein levels during childhood and early adulthood were recently explored in an article published in Nature Communications, which highlighted the importance of accounting for age and sex when analysing protein levels in children. proteinatlas.org/news/2026-0…