@ProfKalium

Ion Channel Biophysics, K+ Channels, OXION PhD programme, @UniofOxford @OxfordPhysics @KavliOxford etc... Find me now on Bluesky....

 Oxford, England
biophysics.physics.ox.ac.uk/tucker/
Joined January 2017
  • Tweets1.5K
  • Following401
  • Followers1.3K
104Media
ProfKalium.bsky.social
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Stephen J. Tucker retweeted
RSC BMCS@RSC_BMCS28 Oct 2024
Do not forget to submit an oral abstract for 8th RSC-BMCS / SCI Symposium on Ion Channels as Therapeutic Targets! This symposium will showcase the most recent advances to aid the design of new ion channel therapeutics and promote interaction between scientists with a shared interest in the field of ion channel drug discovery. 🙌 Click here to submit an abstract 👇 lnkd.in/eQXsgHcP 🗓️Deadline: 15th November #IonChannels25
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Want to know when is a hydrophobic gate not a hydrophobic gate? Read more here in this Viewpoint: rupress.org/jgp/article/154/…
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Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease biorxiv.org/cgi/content/shor… #biorxiv_biophys
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Our latest Preprint: More new CryoEM structures of TASK1 and TASK3 @K2pChannels including the G239R disease-causing mutant structure of TASK3 (KCNK9 Imprinting Syndrome/Birk Barel Syndrome) biorxiv.org/content/10.1101/…
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I’m so glad at least one moment of this was captured for posterity. Fred is one of the true pioneers in the field and this was simply one of the most amazing talks I have heard.
Claudia Moreno@Cladoni12 Jul 2024
History of ion channels by one of his authors. Fred Sigworth’s closing seminar at the GRC was simply beautiful
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youtu.be/db1afWzokOU
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Stephen J. Tucker retweeted
Baron Chanda@ChandaLab0620 Jul 2024
One of the unforgettable moments at the 2024 Ion Channels GRC was the closing lecture by Fred Sigworth. If you missed it, here it is.. youtu.be/db1afWzokOU?si=hyCJ…

Voltage-gating emerges from the mist

See a new, accelerated version of this talk at https://youtu.be/wHE...

youtube.com
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scilifelab.se/event/linkopin…

Linköping Ion Channel Meeting

The second Linköping Ion Channel Meeting will take place on October 6-7, 2027. Click the button above to find out more! Welcome to the first Linköping Ion Channel Meeting Linköping […]

scilifelab.se
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Stephen J. Tucker retweeted
Slav Bagriantsev@SlavBagria10 Jul 2024
I feel hungry after just a few hours, but hibernating squirrels don't even after several months. This remarkable feat is possible due to reversible central hypothyroidism. A new study from the Gracheva lab by Sarah Mohr and @rafaeldaipra rdcu.be/dNmeC
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Exciting times for @K2pChannels indeed!
Dan Minor@ElectrosomeUCSF27 Jun 2024
Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site biorxiv.org/content/10.1101/… New work from our lab shows a hydrophilic gate (the flow restrictor) and polyunsaturated fatty acid site. See also work from @ProfKalium
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Our latest Preprint on structure of THIK-1 K2P Channel - lots of new features including a lower 'Y-gate'. biorxiv.org/content/10.1101/… Also exciting that Dan Minor's group @ElectrosomeUCSF have almost identical results and some additional structures - also on @biorxiv_biophys

CryoEM Structure of the human THIK-1 K2P K+ Channel Reveals a Lower ‘Y-gate’ Regulated by Lipids...

THIK-1 ( KCNK13 ) is a halothane-inhibited and anionic lipid-activated Two-Pore Domain (K2P) K+ channel implicated in microglial activation and neuroinflammation, and a current target for the...

biorxiv.org
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Structure of Kir7.1 biorxiv.org/content/10.1101/…

Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiolo...

Hereditary defects in the function of the Kir7.1 in the retinal pigment epithelium are associated with the ocular diseases retinitis pigmentosa, Leber congenital amaurosis, and snowflake vitreal...

biorxiv.org
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Our latest paper on Extracellular modulation of TREK2 K2P channels by nanobodies is now finally online in @NatureComms nature.com/articles/s41467-0…

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of...

Nature Communications - K2P channels are important regulators of cellular electrical activity. Here the authors show how nanobody fragments can be used to detect and modulate TREK2 K2P channel...

nature.com
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"A fundamental mistake in receptor theory has led to an enduring misunderstanding of how to estimate the affinity and efficacy of an agonist." arxiv.org/abs/2402.14617
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Matthew Freeman and Fran Ashcroft discuss "The Mould in Dr Florey's Coat" by Eric Lax in this #podcast podcasts.ox.ac.uk/good-scien…
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I am sad to report that Bill Catterall has died. He was an enormous presence @UW.
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A mechanism of lysosomal calcium entry | Science Advances science.org/doi/full/10.1126…

A mechanism of lysosomal calcium entry

Human TMEM165 is a proton-activated, lysosomal Ca2+ importer.

science.org
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Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis | Nature nature.com/articles/s41586-0…

Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis

Nature - The voltage-gated sodium channel Nav1.7 has a dual role in osteoarthritis—in chondrocytes, it promotes joint damage, and in dorsal root ganglia neurons, it increases pain transmission.

nature.com
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Stephen J. Tucker retweeted
Membrane Protein PDB@MemProtPDB9 Dec 2023
Eukaryotic Kv channel Shaker inactivates through selectivity filter dilation rather than collapse | Science Advances science.org/doi/10.1126/scia…
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