James ODonnell retweeted
Excited to see our @NIH NHLBI / @RCSI_Irl @stjamesdublin collaboration looking at the role of endotheliopathy, VWF/ADAMTS13 in #VEXAS thrombosis is now out in @BloodPortfolio. @ProfJSODonnell Anne-Marije Hulshof ashpublications.org/blood/ar…
James ODonnell retweeted
Mild isolated functional VWF defects in the 30 to 50 IU/dL range are common and are associated with significant bleeding in some patients. ow.ly/PlcA50Wrynz #thrombosisandhemostasis #clinicaltrialsandobservations
James ODonnell retweeted
New RCSI research has identified a previously unrecognised subgroup of patients with the bleeding disorder von Willebrand disease.
The findings challenge current diagnostic practices and highlight a need to adapt clinical guidelines.
➡️ rcsi.com/dublin/news-and-eve…
#RCSIdiscover
James ODonnell retweeted
Celebrating the great news of promotion to Professor of nursing for our colleague @dodonnell22 @ulsterunisonp Congratulations Professor O’Donnell!! We are #proudofuu #ulsternurse #ulsterparamedics
James ODonnell retweeted
Delighted to be promoted to Professor of Nursing. Thanks to everyone who has supported me and believed in me.
Celebrating the great news of promotion to Professor of nursing for our colleague @dodonnell22 @ulsterunisonp Congratulations Professor O’Donnell!! We are #proudofuu #ulsternurse #ulsterparamedics
James ODonnell retweeted
Montgomery Educational Symposium on Hemostasis (MESH) was a huge success thanks to the incredibly bright minds and warm hearts that gathered to honor ‘Montgomery, Milwaukee’s’ amazing career @VersitiResearch
James ODonnell retweeted
President of Haematology Association of Ireland @Paulv8205 giving an overview of 25 years of the #HAI and recognition of Liam O’Connell - Ireland’s first haematologist.
@stjamesdublin @tcddublin @CancerInstIRE
James ODonnell retweeted
BT200 interaction with the VWF-A1 domain in proximity to this lysine cluster significantly attenuates macrophage LRP1-mediated clearance. ow.ly/qa6A50Twvon #thrombosisandhemostasis
James ODonnell retweeted
Very excited to share our science and kick off new collaborations. Coffee is also mentioned, which is excellent.
REMINDER: Our next #PBSResearch seminar series supported by @thermofisher is tomorrow Tues. 1st Oct. at 3pm in the Cheyne LT.
We are thrilled to welcome Prof. James Luyendyk (@TFFVIIa) from @michiganstateu to see his fascinating work ‘targeting vWF to accelerate liver repair’🔬
James ODonnell retweeted
REMINDER: Our next #PBSResearch seminar series supported by @thermofisher is tomorrow Tues. 1st Oct. at 3pm in the Cheyne LT.
We are thrilled to welcome Prof. James Luyendyk (@TFFVIIa) from @michiganstateu to see his fascinating work ‘targeting vWF to accelerate liver repair’🔬
James ODonnell retweeted
#BT200 prolongs VWF half-life by attenuating macrophage-mediated clearance and specifically the interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1. A anovel therapeutic approach for #von Willebrand disease and #hemophilia. ashpublications.org/blood/ar…
James ODonnell retweeted
Valuable information on the mode of action of BT200 published in @BloodAdvances. It blocks VWF clearance through LRP1. BT200 is a treatment being developed for non-type 3 von Willebrand disease. tinyurl.com/mss46ja3 #VWD #VWF #Willebrand
James ODonnell retweeted
👀Let’s take a peek at the story that made our #october #coverart
In #vWD type vicenza, #vWF clearance is accelerated. How⁉️
🧬 Atiq et al. showed that the VWF-R1205H mutation leads to loss of positive charge and increased binding to macrophage clearance receptors via LRP1 and SR-AI.
A significant novel insight into the mechanism of this complex disease.
✍️@DavidLillicrap @Jme_os @ProfJSODonnell
jthjournal.org/article/S1538…
James ODonnell retweeted
▶ Advanced analysis of platelet metabolism and mitochondrial function
Sonia Águila, @Sonia_AguilaM, Centro Regional de Hemodonación, IMIB-Pascual Parrilla, UCAM, Murcia (Spain)
▶ How is NO metabolism regulating platelet function Paolo Gresele, University of Perugia (Italy)
▶ Platelet heterogeneity in health and disease
Paul C. Armstrong, Queen Mary University of London Centre for Immunobiology, Blizard Institute (United Kingdom)
@isth #SETH #PlateletResearch #plaquetas #platelet #Murcia
James ODonnell retweeted
Novel functions for von Willebrand factor
ow.ly/rvCi50Tr8cP #thrombosisandhemostasis #vascularbiology
James ODonnell retweeted
Dr Alain Chan Kwo Chion @RCSIPharmBioMol features in the @siliconrepublic list of researchers to follow 🔬
Based at @IrishCtrVascBio his research focuses on approaches to treat the common bleeding disorder von Willebrand disease.
More ➡️ siliconrepublic.com/innovati…
#RCSIdiscover
James ODonnell retweeted
The gene encoding von Willebrand factor is located on the short arm of chromosome 12, and a highly homologous pseudogene that does not generate functional transcripts has been mapped on chromosome 22. #VWD go.nature.com/4cSDuCA
ALT Schematic of the structure of the gene coding for von Willebrand factor.
James ODonnell retweeted
Prof. Hervig will be sorely missed by all in the IBTS. We wish him a very happy retirement!
Wishing my esteemed colleague Prof. Hervig a very happy retirement!
A Laveesha pizza board to remind him of the wild Atlantic way as he returns to Norway 🇳🇴
#bloodylegend #transfusionmedicine
James ODonnell retweeted
von Willebrand factor synthesis occurs in endothelial cells and megakaryocytes as a single-chain polypeptide that, subsequently, undergoes extensive processing. #VWD go.nature.com/4cSDuCA
ALT A Figure showing the life cycle of von Willebrand factor.
James ODonnell retweeted
Our NEW Primer on von Willebrand disease is live today!
By @OmidSeidi, Eikenboom, @cecile_denis, @VeronicaFlood18, @james_paulad, @LentingPeter, Baronciani, @ProfJSODonnell, @DavidLillicrap & @flora_peyvandi #Hematology #VWD
Check it out here: go.nature.com/3WyE82i