
🧠Neurosurgeon-Scientist | AI, Brain Cancer and Digital Health Researcher | Ambidextrous | Author |🇳🇵🇬🇧 @TheCrick @kingsneuro @kingsimaging @naamii_nepal
London, UK
Joined March 2012
- Tweets393
- Following989
- Followers1K
- Likes6.1K
Pinned Tweet
“🚨 Podcast 🚨”
Dive deep into the world of neuro-oncology with ‘Neuro-oncology Talks | The Deep Dive.’ Explore groundbreaking research, AI in medicine, and the future of brain tumor treatment. 🎙️
Listen now: podcasts.apple.com/gb/podcas…
#NeuroOncology #CancerResearch #AIInMedicine
Prajwal Ghimire retweeted
1/Radiologist not answering the phone?
Just want a quick read on that stat head CT?
Here's a little help on how to do it yourself w/a thread on how to read a head CT!
Our paper on clinical cortical and subcortical map of motor homunculus from @KingsNeuro has been included in 100 years in 💯 papers of @The_SBNS centenary celebration publication.
Thank you @The_SBNS.
Replying to @KingsNeuro
4/6
2021-Ghimire P, Lavrador J, Baig A, Furlanetti L, Brogna C, Gullan R, Vergani F, Bhangoo R, Ashkan K. Intraop mapping of pre-central motor cortex and subcortex... Brain Struct Funct. 2021 Jun;226(5):1601-1611.
🔗doi.org/10.1007/s00429-021-0…
👏@prazNeuro
Prajwal Ghimire retweeted
Fantastic illustrations! Very useful to understand the concepts! @PrazNeuro
Replying to @KingsNeuro
3/3 ⚠️ Surgical Safety:
👉Complications: in 48.9% , emphasizing the procedural challenge of deep-seated ventricular corridors.
👉Decisions should tailor the approach to specific tumour biology and patient presentation
Illustrations @PrazNeuro 👏
The choice of surgical technique alone does not govern complete resection or CSF diversion success. Instead, individual patient presentation, anatomical location, and tumour biology should guide the tailored selection of surgical approach. 👇
Excellent team effort @KingsNeuro 👏
Hot off Press:📜
1/3 🧵 How do conventional craniotomy and minimally invasive surgery (MIS) compare for intraventricular tumours?
A systematic review and individual patient data meta-analysis of 1,500 patients (361 studies) provides key clinical insights. 👇
@AsfandBm
The Advanced 3D Neurosurgical Anatomy Atlas (brain & spine) is now public.
Open Access | Free
Any browser, 3D, VR and mobile version
10 interactive specimens, 34 guided surgical approaches, Rhoton Collection plates, white matter dissection walkthrough.
prazg.github.io/3D_Neurosurg…
Prajwal Ghimire retweeted
BREAKING NEWS
The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
While navigated intra-op ultrasound offers a low-cost, real-time tool to compensate for dynamic intraoperative brain shift, its greatest standalone utility may be in lesions with purely anatomical endpoints, such as brain metastases.
@KingsNeuro @lavrador_jose
Infographic 👇
1/4 🧠 How do neurosurgeons maximize tumour cytoreduction while safeguarding neurological function in eloquent brain regions?
A study of 104 patients @KingsCollegeNHS evaluated navigated intraoperative ultrasound (N-ioUS) integrated into a modern multimodal workflow:👇
@feras199
Prajwal Ghimire retweeted
NEW Viewpoint: The clinician–artificial intelligence scientist: a proposed career pathway in medicine.
Read it here: thelancet.com/journals/landi…
Prajwal Ghimire retweeted
Waving the white flag when it comes to white matter anatomy?
Turns out white matter anatomy isn’t black & white!
Diffusion tensor imaging or DTI can help us to see the different systems in the white matter.
But often we don’t have DTI on routine brain MRIs.
So how can we tell if pathology is affecting important white matter functional anatomy?
We have to estimate, based on landmarks
Here’s how to remember the major tracts:
Motor tracts/Posterior Limb of the Internal Capsule/Corticospinal tract:
Corticospinal tract goes through your CORE. What is central in the brain? The ventricles!!
It runs along the lateral aspect of the lateral ventricles
Corpus Callosum:
Letter C looks like the curves of the splenium and genu of the corpus callosum
Superior Longitudinal Fasciculus:
What is superior & long in your body—your arms! Superior longitudinal fasciculus looks like arms hanging down along the lateral aspect of the brain
Inferior fronto-occipital fasciculus & Inferior longitudinal fasciculus
What’s inferior & long in your body—your legs! These curve around posteriorly and inferiorly, like two legs with their heels touching
So now you can always find the major white matter tracts!
Hopefully, now you can be right about what’s white!
Answering "is there a trial for this?" in neuro-oncology clinic meant opening six registries.
Brain Trials Finder searches all six at once: US, UK, EU, India, China, WHO.
Filter by age, KPS, recurrence. Every match score is itemized.
Free, open source.
prazg.github.io/brain_trials…
Prajwal Ghimire retweeted
Worried that hydrocephalus is hiding in plain sight?
Normal pressure hydrocephalus (NPH) can mimic volume loss
How can you tell the difference?
Many findings can be seen with NPH—you may use 1 or more. But do you know how well your sign performs?
Here are how common NPH signs perform:
Evans index
SENS: 100
SPEC: 74
Cingulate sulcus sign:
SENS: 63
SPEC: 61
Callosal angle:
SENS: 49
SPEC: 78
Disproportionately enlarged subarachnoid spaces (DESH):
SENS: 94
SPEC: 41
Anteroposterior diameter of the lateral ventricle index:
SENS: 98
SPEC: 100
For the SINPHONI trial, a combination of Evans index > 0.3 & DESH had a 70-80% PPV for shunt responsiveness.
Now you know the signs of NPH & how good they may or may not be. Hopefully, you can now set the bar high when it comes to hydrocephalus!
Prajwal Ghimire retweeted
Just because you don’t see it, doesn’t mean it’s not there!!!
Just because you don’t see all cranial nerves on MRI doesn’t mean they aren’t there!
You must know their anatomy so you know when pathology might affect them.
Here is a figure w/the anatomy you NEED to know!
➡️Just remember this easy rule of four from Peter Gates:
There are:
🔸 4 cranial nerves from above the pons (including 2 from the midbrain)
🔸4 from the pons
🔸And 4 from the medulla oblongata!
Now you won't have be nervous when it comes to this nerve anatomy!
Prajwal Ghimire retweeted
Online now: Subtypes of neurons in the cerebellar cortex dlvr.it/TTwMpc
Prajwal Ghimire retweeted
An artificial neural network built into a computer memory chip reconstructs the human cortex with high accuracy in real time.
Learn more in a new #SciencePerspective: scim.ag/3TYzDPA
Prajwal Ghimire retweeted
53 presentations. One department.
@KingsNeuro will be showcasing work across neuro-oncology, vascular, spine, skull base, trauma, paediatrics, functional, global, basic science and more at #SBNS100 this October.
An incredible team effort and testament to collaborative research!
The preliminary programme for #SBNS100 is now available! Explore a comprehensive scientific programme covering neurosurgery, from clinical practice and training to the latest research, alongside contributions from the wider neuroscience community sbns.org.uk/event-calendar/s…
🎓PhD ✔️
💥After years of research, late nights, setbacks and perseverance, I’m incredibly happy to have passed my PhD viva at @KingsImaging @KingsCollegeLon .
Excited for the next chapter ! 🎓🧠
Grateful to my supervisors, examiners, mentors, colleagues & patients. – at Greenwich, London
Thrilled to share our gbm radiogenomics and global neuro work is heading to two major meetings this autumn 🧠
🇮🇹 @EANOassociation 2026 : 3 abstracts (oral + poster)
🇬🇧 @The_SBNS 100 : 4 oral presentations
🙏YRI (@COSTprogramme Net4Brain) & @The_SBNS Trainee conference awards.
🧠 One figure, two classifications:
In our new @BrainSpineJ paper we propose simple end-of-surgery scheme for glioblastoma:
👉5-ALA residual → none / focal (1–2 walls) / diffuse (all walls)
👉Recurrence → focal / diffuse / distal
Diffuse residual tracked with worse OS & PFS.
Replying to @KingsNeuro
We classified end-of-resection 5-ALA residual as none / focal (1–2 walls) / diffuse (all walls) in 46 IDH-wt GBMs, with blinded central radiology review of recurrence. (2/4)
🖼️illustration by @PrazNeuro
🤔concept by @lavrador_jose
Prajwal Ghimire retweeted
Publication!
🧠@BrainSpineJ : Does the pattern of leftover 5-ALA fluorescence in glioblastoma surgery predict outcome?
We looked beyond "fluorescence present vs absent" and asked whether how residual is distributed matters. 🧵 (1/4)
@feras199 @PrazNeuro @AsfandBm @lavrador_jose
Prajwal Ghimire retweeted
1/Ready for a throw down?
MMA fights get a lot of attention, but MMA (middle meningeal art) doesn’t get the attention it deserves!
This month’s @theAJNR SCANtastic tells you all you need to know!
ajnr.org/content/47/6/1515




































