@PratLab

Prat Lab @CRCHUM. Unraveling the migration mechanisms of immune cells across the brain barriers in multiple sclerosis 🔬🧠 Tweets by lab members.

Joined August 2021
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  • Following109
  • Followers276
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A la retraite du département de Neurosciences @chumontreal @CRCHUM @ChuSteJustine @UMontreal, de riches échanges se font entre chercheurs et cliniciens pour pousser la recherche sur les maladies du système nerveux encore plus loin
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Comprehensive and insightful review by @PratLab discussing the role of genes & environment on BBB disruption in MS and the therapeutic implications of mesenchymal stromal cells and antibodies targeting cell adhesion molecules or #fibrin to halt neurodegeneration. @TheLancetNeuro "Blood–brain barrier dysfunction in multiple sclerosis: causes, consequences, and potential effects of therapies" thelancet.com/journals/laneu…
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In our January 2024 issue: the blood–brain barrier in multiple sclerosis, reviewed by Bettina Zierfuss and colleagues from @PratLab thelancet.com/journals/laneu…
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Please share! The 2024-2025 #endMS_SPRINT and 2024 #endMS_SummerSchool competitions are NOW OPEN! Inviting graduate students, post doctoral and clinical fellows, to apply by Feb 15, 2024. For complete details: endmstrainingprogram.ca @ChristinaWolfs1 @MSCanOfficial @umanitoba
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Excited to be part of @MSCanOfficial #EndMS 2023 in Toronto! I’m grateful for the chance to engage with the MS research community. I’ll be presenting the latest work on cytokines and endothelial barriers in the brain from the @PratLab with my poster #97 at 17:15, let’s connect!
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In this week’s #neuroimmunology special issue, Thai and @PratLab explore advances in immune cell carriers that ferry therapeutics across the #BloodBrainBarrier, which are opening a new frontier in #DrugDelivery for central nervous system disorders. @CRCHUM scim.ag/4PP
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Check out our recent Viewpoint 👇
Karine T@KarineThai_9 Nov 2023
Our Viewpoint in the latest special issue of @ScienceTM highlights how immune cell properties can be harnessed to enable targeted drug delivery to brain regions previously inaccessible to free drugs. Read more here: science.org/doi/10.1126/scit… @PratLab

CNS therapeutics: Immune cells break the barriers

Immune cell carriers enable targeted drug delivery to previously inaccessible brain regions through their capacity to cross the blood-brain barrier.

science.org
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Hoping to spread the word: We've started a study to see how circadian rhythms might affect those living with MS in Canada. Please share/RT across your networks! @KarimiLab @jrplemel @YegMs @TheNeuro_MNI @DCNSNeuro @PratLab @Craigurs @uOttawaBMRI @Raph_Schneider @UnityHealthTO
CircaPain@CircaPain16 Oct 2023
Do you live with Multiple Sclerosis? Do you experience pain and/or fatigue? Please consider participating in our sibling study CircaMS or sharing it with your network! Get involved and take the survey here: redcap.link/caoh8m30 Check out our website circams.ca/
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Very thrilled to have had the opportunity to present my PhD work in the @PratLab about the use of single-cell immune profiling for prediction of MS activity today at @ECTRIMS #MSMilan2023 🧠
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Leucocyte trafficking inhibition to modulate neuroinflammation: is MCAM a next generation target (and more clever than Natalizumab)? A commentary on novel findings and strategic thoughts around this: pubmed.ncbi.nlm.nih.gov/3694…

Targeting MCAM for next-generation modulation of leucocyte trafficking - PubMed

This scientific commentary refers to ‘MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes’ by Charabati et al. (https://doi.org/10.1093/ …

pubmed.ncbi.nlm.nih.gov
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Interested in exciting research on the BBB and MS? 🧠 The Prat lab is recruiting talented and motivated graduate students and post-docs! DM us to know more about available positions and send applications to [email protected]. Please share!
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If you’re interested in machine learning, come see my poster p290 ‘Machine Learning Identifies a Combination of Immunological and Clinical Parameters as the Best Predictor of MS Disease Progression’ at the #ACTRIMS2023 poster session tonight! #MultipleSclerosis @PratLab @endMS
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Which endothelial cell types are most responsive to neuroinflammation? Read our new article to find out and feel free to play with the two interactive R shiny applications to identify new targets for your projects. nn.neurology.org/content/10/…
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Read more about our latest story published in Brain about the role of MCAM+ brain endothelial cells in the recruitment of pathogenic T cells in multiple sclerosis!
Stephanie Zandee@StephanieZandee9 Nov 2022
Read about the latest @PratLab research in Brain 🔥🧫🥼🧬🔬we have investigated the role of MCAM on the BBB in multiple sclerosis 👇 doi.org/10.1093/brain/awac38… #MultipleSclerosis #BBB #endMS @MSSocietyCanada
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Check out our recent study led by @AP_Fournier: CLMP Promotes Leukocyte Migration Across Brain Barriers in Multiple Sclerosis nn.neurology.org/content/9/6…
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The Prat lab is recruiting graduate students! Please share and send your application to [email protected] if interested. More info about the research here: neurosciences.umontreal.ca/r… @CRCHUM @UMontreal

Alexandre Prat - Département de neurosciences - Faculté de Médecine - Université de Montréal

Dr Prat a obtenu son baccalauréat (B. Sc.) en biochimie à l’Université de Montréal en 1990 et un MD-MSc en 1995. Il a complété sa résidence en neurologie à l’Université […]

neurosciences.umontreal.ca
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Our latest paper is out! The first "official" research paper of my beautiful CBN team @uhasselt, with @PhDory as first author (but this publication was a team effort!). Check it out! Especially if you're into #bloodbrainbarrier #multiplesclerosis 👇👇👇 link.springer.com/article/10…
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Such a great talk from @JenGommerman today at the @CRCHUM! #BCells #Aging #GreyMatter #WomenInSTEM
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Check out the most recent publication from the Yong lab led by our talented Jeff Dong on how age impacts microglia's capacity to buffer CNS damage! nature.com/articles/s43587-0…
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Huge congratulations to our PhD student @KarineThai_ for the best presentation award in the ADENUM last event! 🥳🤩 we're so proud of you!
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