🎉 𝐂𝐨𝐧𝐠𝐫𝐚𝐭𝐮𝐥𝐚𝐭𝐢𝐨𝐧𝐬 𝐭𝐨 𝐃𝐚𝐯𝐢𝐝 𝐂. 𝐏𝐨𝐰𝐞𝐫𝐬, 𝐒𝐚𝐦𝐲𝐚 𝐒𝐚𝐦𝐚𝐧𝐭𝐚, 𝐋𝐚𝐮𝐯 𝐏𝐚𝐭𝐞𝐥, 𝐃𝐢𝐲𝐚𝐬𝐡𝐚 𝐌𝐚𝐧𝐧𝐚, 𝐚𝐧𝐝 𝐌𝐞𝐥𝐢𝐬𝐬𝐚 𝐎𝐣𝐞𝐝𝐚 𝐨𝐧 𝐭𝐡𝐞𝐢𝐫 𝐧𝐞𝐰 𝐉𝐀𝐂𝐒 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧: “𝐁𝐚𝐬𝐞-𝐅𝐫𝐞𝐞 𝐂-𝐍 𝐂𝐫𝐨𝐬𝐬-𝐄𝐥𝐞𝐜𝐭𝐫𝐨𝐩𝐡𝐢𝐥𝐞 𝐂𝐨𝐮𝐩𝐥𝐢𝐧𝐠”! 📖 pubs.acs.org/jacsat/article/… 🔬 This study introduces a nickel-catalyzed base-free C-N cross-electrophile coupling (XEC) strategy that enables efficient C-N bond formation by coupling electrophilic carbon and nitrogen partners under mild conditions. 🔹 A philicity-mismatched Ni-catalyzed C-N cross-electrophile coupling was developed using electrophilic carbon and nitrogen precursors, eliminating the need for basic additives. 🔹 The method exhibits broad functional group tolerance, including excellent compatibility with base-sensitive substrates and late-stage functionalization. 🔹 Electrophilic nitrogen precursors can be readily prepared from diverse starting materials, including C-H bonds and olefins. 🔹 A two-step, one-pot N-phenothiazination/C-N XEC sequence enables the efficient functionalization of amine-containing bioactive molecules and the synthesis of designer secondary, tertiary, and unsymmetrical diamines. 🔹 Mechanistic studies support a Ni(II)-aryl-amido intermediate as the key species responsible for promoting cross-selectivity while suppressing homocoupling. 🐝 We are pleased to see that 4,4'-di-tert-butyl-2,2'-bipyridine, a key ligand used in this study, was sourced from AmBeed. 𝗧𝗿𝘆 𝗔𝗺𝗕𝗲𝗲𝗱’𝘀 𝗯𝗶𝗽𝘆𝗿𝗶𝗱𝗶𝗻𝗲 𝗹𝗶𝗴𝗮𝗻𝗱𝘀 𝗶𝗻 𝘆𝗼𝘂𝗿 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵！ ambeed.com/search/StructureS… #AmBeed #JACS #OrganicChemistry #CrossElectrophileCoupling #NickelCatalysis #CNCoupling #Bipyridine #ResearchTools #BuildingBlocks #Paper #Chemistry