Group at CIB-CSIC working on Posttranslational Modification of Proteins, focusing on Lipoxidation, Intermediate Filaments, Drug-protein interactions.
CIB-CSIC, Madrid, Spain
Joined October 2018
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Vimentin remodeling in response to oxidants and electrophiles is modulated by pH | Science Advances science.org/doi/10.1126/scia…
What we have been working on lately at @CIB_CSIC. "Mimicking two posttranslational modifications associated with oxidative stress affords phase separation of vimentin" biorxiv.org/content/10.64898…
European researchers' Night. Nuria goya and Diego Moneo @CIB_CSIC, present the project Astromad astromad.eu, "Towards a better understanding of Alexander disease", funded by @CaixaResearch at @CaixaForum. Thanks to grants "Alexander"-EJP Rarediseases, @EpiLipidNET
Perez-Sala Lab retweeted
Announcing 22nd SFRR-International Biennial Meeting (host SFRR-Europe) in Galway, Ireland 3-6 June 2025 (sfrrgalway2025.com). Call for Symposia and SFRRI Award Lectures (see sfrr.org) @SFRR_Europe @SFRRAustralasia @SFRBM @elsbiomedchem @physoc @BiochemSoc
After a long time watching vimentin droplets induced by oxidants, we report that "Oxidative stress elicits the remodeling of vimentin filaments into biomolecular condensates" sciencedirect.com/science/ar… Thanks to colleagues from @CIB_CSIC, @ConnectingIFs, @SFRR_Europe for feedback
Perez-Sala Lab retweeted
We introduce the flyer of the next @GEIRLI2 meeting which we, @bioxgroupwill, host in Oviedo. We welcome everyone interested in redox and free radicals!!!
Looking forward to meeting the Redox redoxistanbul2024.com/ and Intermediate Filament communities grc.org/intermediate-filamen…, sharing our results, and enjoying the advances in these fields. @SFRR_Europe, @ConnectingIFs
Our recent observations while playing with oxidants and vimentin network remodeling: "Formation of vimentin biomolecular condensate-like structures under oxidative stress" biorxiv.org/content/10.1101/…
Perez-Sala Lab retweeted
📢 Are you interested in laminopathies, desminopathies, Alexander disease, etc. Then join us in Spain (June 15-21, 2024), where we will share and discuss the latest on intermediate filament research in a beautiful setting. Apply now: GRC: tinyurl.com/43jms2t5 @ConnectingIFs
Perez-Sala Lab retweeted
Your body is full of essential fatty & oily compounds known as lipids. Today we take a look at the @EpiLipidNET network comprising 450 lipid scientists who celebrate their 4th year of transformative research & public engagement ⬇
#COSTactions #EpiLipidNET #lipids
Perez-Sala Lab retweeted
And we also found that pharmacological up regulation of mitophagy restores age-dependent neurological decline! Contrats to all authors for a great team effort! 👏💪😎
Thrilled to share that my first first-author paper is finally out in @NatureComms! 📝We analyzed mitophagy in several organs and found that it actually increases with age... to decrease inflammation!🔬🧓🏼 @patricia_boya @CIB_CSIC @unifr @CEBAS_CSIC
nature.com/articles/s41467-0…
Perez-Sala Lab retweeted
An evolutionarily conserved molecule used to make cholesterol also acts as a defence against cell death.
Donna Zhang discusses how this finding might lead to new ways to treat cancer. go.nature.com/3UpdWX8
Key role of vimentin in the organization of the primary cilium biorxiv.org/content/10.1101/…. First steps in the pursuit of vimentin till the tip of the cell's "antenna". @CIB_CSIC, @ConnectingIFs.
Here are our first observations on how vimentin reorganization upon exposure to oxidants depends on pH.
Best wishes to all! @CIB_CSIC, @EpiLipidNET, @ConnectingIFs
Intracellular pH modulates vimentin remodeling in response to oxidants biorxiv.org/content/10.1101/…
The redox-responsive roles of intermediate filaments in cellular stres... sciencedirect.com/science/ar… Exposing connections between intermediate filaments and redox biology. Curr Opin Cell Biol Special Issue on Cell Architecture @CIB_CSIC @CaixaResearch @EpiLipidNET @ConnectingIFs
Desmin Reorganization by Stimuli Inducing Oxidative Stress and Electrophiles: Role of Its Single Cysteine Residue mdpi.com/2461032 #mdpiantioxidants via @antioxidants_OA, @EpiLipidNET, @CIB_CSIC, Exploring the redox connections of intermediate filaments.
European Researchers' Night. Alma Martínez, Nuria Goya, Elena Hernández & María Pajares @CIB_CSIC present the project Astromad-From GFAP mutations to neurodegeneration. Towards a better understanding of Alexander disease, funded by @CaixaResearch, at @CaixaForumMAD. @EpiLipidNET
Perez-Sala Lab retweeted
Protein Lipoxidation at the Crossroads between Reactive Lipid Species and Redox Signaling mdpi.com/si/138789 #mdpiantioxidants via @antioxidants_OA
Consider sending your work on reactive lipid species or protein lipoxidation to this Special Issue (deadline Nov 15)
Perez-Sala Lab retweeted
Junto @FundacionLuzon hemos impulsado cinco proyectos sobre ELA liderados por investigadores de:
👉la @UABBarcelona,
👉la @USPCEU,
👉la Fundación @navarrabiomed,
👉el @CIB_CSIC
👉y el @CNIOStopCancer
Te lo explicamos en el blog #CaixaResearch.👇
🔗 bit.ly/47mPSIC
Protein Lipoxidation at the Crossroads between Reactive Lipid Species and Redox Signaling mdpi.com/si/138789 #mdpiantioxidants via @antioxidants_OA
Consider sending your work on reactive lipid species or protein lipoxidation to this Special Issue (deadline Nov 15)