Chemistry lab at the University of Oregon. Focused on molecular recognition, physical organic chemistry, and chemical biology of reactive S and Se species.

Eugene, OR
Joined November 2010
New @ChemRxiv preprint: Substituent Effects Govern the Fidelity of Responsive Persulfide Donors. When do persulfide donors release persulfides? We identify pathways and parameters for effective persulfide release. Great work Ismail! chemrxiv.org/doi/full/10.264…
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Congratulations Dr. Li @keyanl10 on a great PhD defense! Thanks for all of your creativity and hard work in expanding the bioinorganic chemistry of reactive S & Se species!
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Upcoming PhD defense in our lab this week from Keyan (@keyanl10) on Wednesday!
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New Chem Comm paper on light activated HCN donors! We expand different linkages compatible with responsive HCN release, using direct HCN measurements to understand efficiency & selectivity. Great work Ally! doi.org/10.1039/d6cc03475f
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Following an oustanding 8th World Congress on H2S in Biology & Medicine in Fribourg, Switzerland hosted by Csaba Szabo, we will be hosting the 9th iteration of this meeting in Eugene, OR in 2028!
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New @ChemRxiv preprint: A Structural Model for Mononuclear Fe(II) Alkyl Persulfide Intermediates and its Sulfide Release Chemistry. Includes synthesis, characterization, and reactivity of a mononuclear Fe-SSR species. Great work Keyan (@keyanl10)! chemrxiv.org/doi/full/10.264…
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Nice article on the impacts of the UO NRT Molecular Probes and Sensors graduate training program (run by @v_derose w/ DW Johnson, @mdpluth). Multiple past & current group members have been supported by this program that spans across scientific areas. research.uoregon.edu/news/mu…
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New @ChemRxiv preprint: Closing the H2S/NO Signaling Loop: Nitric Oxide Regeneration by a Synthetic Zn2+ Persulfide via Transnitrosation and Nitrite Reduction Great work @SayanAtta95, @keyanl10, & Alex! Computational work by @PAChampagne. chemrxiv.org/doi/full/10.264…
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Excited to share our Chem Rev on the bioinorganic chemistry of persulfides! Includes biological chemistry, bioinorganic models, inorganic systems, & isolable S/Se compounds. A huge congrats to Keyan (@keyanl10) for this heroic undertaking! pubs.acs.org/doi/10.1021/acs…
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Posters from 3 of our outstanding undergrads at the UO Undergraduate Research Symposium today! Great job Addison, Christopher, & Aleanna!
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🦆 🦆 The Duck approves! 🦆 🦆
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(1/2) Our awesome Chemistry and Biochemistry graduate students represented us at the Chemical Biology and Physiology Conference 2025 in Portland, Oregon last week. Go Ducks!🦆 @v_derose @PluthGroup @uoCHandBIC @Gaby_Bailey_6 @Katelyn_alley14
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Do ‘gasotransmitters’ need to be gases? Andy makes the case in Redox Biology for Protic Small Molecule Bioregulators (PSMBs): a cross-cutting class of small molecules where protonation states impact biological speciation, permeability, & action. @agdavis98 doi.org/10.1016/j.redox.2025…
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Curious about the impacts of Lewis acids on persulfide & thioselenide chemistry? Check out Keyan & Addison’s paper using isolated ZnSSR & ZnSeSR complexes to directly study reactivity. Lots of insights from 77Se NMR & XRD! @keyanl10 @angew_chem onlinelibrary.wiley.com/doi/…
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Hydrogen cyanide (HCN) is the newest gasotransmitter & a key protic small molecule bioregulator. We developed a platform approach to develop & deploy biocompatible responsive chemical tools for HCN delivery. Check out Mike's paper in @angew_chem! onlinelibrary.wiley.com/doi/…
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🎃🎃Happy Halloween from the Pluth Lab! 🦇🦇
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New Chem Commun paper on Cys-activated H2Se delivery from isoselenocyanates. Includes mechanistic insights, solution characterization, and cell imaging. Great work Reis, Keyan, Christopher, Arman, Turner, & Kaylin! pubs.rsc.org/en/content/arti…
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New ACS Chem Biol paper out: No H2S needed - We show that an increasingly common approach for H2S detection actual reports on thiols and esterases. Nice work Haley (@hsmith922), Aleanna, Christopher, & Ally sorting out the chemistry of this system! pubs.acs.org/doi/10.1021/acs…
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