@PlesaLab

Official lab news from the Plesa Lab at @UOKnightCampus

 Eugene, OR
plesalab.org
Joined May 2019
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PlesaLab retweeted
Calin Plesa@calinplesaJun 2
We just preprinted DropSynth-Gold where we replaced PCA with Golden Gate Assembly (GGA) inside emulsion droplets, extending multiplexed gene synthesis to ~3 kb constructs assembled from up to 12 fragments while preserving the scalability of DropSynth. 1/n
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PlesaLab retweeted
Calin Plesa@calinplesaMar 3
New lab preprint: if ML struggles with extrapolation, let's expand the diversity of training data with gene synth, DNA shuffling, and ML gen.... also lots of #FluorescentProteins #ProteinEngineering #MachineLearning #SyntheticBiology 1/n
bioRxiv Synthetic Biology@bioRxiv_synbioMar 3
High Diversity Gene Libraries Facilitate Machine Learning Guided Exploration of Fluorescent Protein Sequence Space biorxiv.org/content/10.64898… #biorxiv_synbio
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Need long-read sequencing? We’ve just completed the first ever run on @uoregon GC3F core’s new @PacBio Revio instrument! Perfect for amplicons too long for Illumina, and with Kinnex prep, you can get >10x more data. Great pricing, no queue, try it out. gc3f.uoregon.edu/pacbio-sequ…
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Lab memes!
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Congratulations @TrieneToScience for winning the people’s choice award at the Oregon Bio Innovation Showcase today!!
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Interested in antibody generation and expression of human proteins in bacteria? If you're at @ProteinSociety tonight check out poster 75 at Bayshore Grand Ballroom D with @MuggleInSynbio to hear about expressing the human proteome in E. coli. @UOKnightCampus
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Powerful 1st-person piece by Knight Campus Dept of Bioengineering Asst Prof Parisa Hosseinzadeh on her long road to recovery following a brain hemorrhage in Nov. 2022. We are so inspired by your strength & determination Parisa and are happy to see you growing stronger every day
nature
@Nature24 Jul 2024
A brain haemorrhage late in pregnancy upended Parisa Hosseinzadeh’s life — and her tenure clock. Thanks to supportive physicians, family and colleagues, she’s restarting her academic career. go.nature.com/3LCnFUl
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At @ProteinSociety tonight check out poster 73 with @AlkynesOfSci to hear about our efforts to deorphanize sensor histidine kinases en masse & poster 117 with @TrieneToScience to hear about BAR-CAT, our approach to scalable enrichment of assembled gene libraries. @UOKnightCampus
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Christmas came early in @PlesaLab with the latest Degenerate DropSynth preprint and the fun was doubled up by lovely Secret Santas in the lab and the Impact & Innovation Award in the annual celebration at @UOKnightCampus 🎉🎁 Signing off 2023 slowly with style 😎
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Story time! Introducing the first of several new flavors of DropSynth #genesynthesis we have been working on, cooked up by @AlkynesOfSci and Sam Hinton. TLDR: We show multiple gene variants assembled per barcoded droplet and 1 kbp lengths. 1/n biorxiv.org/content/10.1101/…

Degenerate DropSynth for Simultaneous Assembly of Diverse Gene Libraries and Local Designed Mutants

Protein engineering efforts often involve the creation of hybrid or chimeric proteins, where functionality critically hinges on the precise design of linkers and fusion points. Traditional methods...

biorxiv.org
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The Department of Bioengineering Seminar Series continued today with Biochemistry PhD student Andrew Holston (Plesa Lab) and #KnightCampusBioe PhD student Sam Lester (Guldberg Lab) who gave talks in the Beetham Seminar Room. The seminar series is held most Mondays.
A grad student named Andrew Holston gives a science talk at a podium

ALT A grad student named Andrew Holston gives a science talk at a podium

A grad student named Sam Lester gives a talk at a podium

ALT A grad student named Sam Lester gives a talk at a podium

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Roughly half the world's population is infected with H. pylori, a leading cause of stomach cancer. A group of UO undergraduates are working on a probiotic they hope could be a gamechanger. The iGEM team is raising funds to take their project to Paris: brnw.ch/21wCypS
A group of eight college students standing together outside

ALT A group of eight college students standing together outside

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Carmen, Yuki, and I representing @PlesaLab from @UOKnightCampus at #VariantEffect23 ! It's been a pleasure to see the amazing research and to share our work.
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Replying to @PlesaLab
@PlesaLab is full of cool surprises!
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When you hit the desk on a weekend to spot an art by the #LOTR geek, and instantly know it’s none other than your PI ! @PlesaLab How many of you have items named in the lab? #research #sciencetwitter #academiclife
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A perfect getaway for a lab retreat on a sunny weekend. More to follow soon! @PlesaLab @sweetcheekswine
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End of the year celebration in @UOKnightCampus and what a blast ❤️❤️❤️
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Just in time for Winter a quick tour of the more unusual things around our lab... 1/n
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Forgotten buffers have been colonized, By herds of wooly mammoths, a surprise, oh my goodness gracious! It's a sight to behold, these majestic creatures on the scene, In the forgotten buffers, they now reign supreme. 8/n
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A perfect 20.000 score on the Nanophotometer Attracts attention, but watch those ratios, or else you'll be a goner! Stay focused, don't let your measurements falter. 9/n
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