Neli PISCO SUAREZ retweeted
🔵 Why can eyebrow neuromodulation relieve migraine?
Stimulating the supraorbital region targets the supraorbital nerve, a branch of the trigeminal nerve (CN V). Electrical stimulation may modulate trigeminal nociceptive signaling involved in migraine, helping reduce pain. 🧠⚡
Neli PISCO SUAREZ retweeted
🔵 A study published in Alzheimer’s & Dementia found that repetitive negative thinking was associated with greater amyloid and tau deposition—two pathological hallmarks of Alzheimer’s disease—as well as cognitive decline.
Neli PISCO SUAREZ retweeted
🔵 A study published in Alzheimer’s & Dementia found that repetitive negative thinking was associated with greater amyloid and tau deposition—two pathological hallmarks of Alzheimer’s disease—as well as cognitive decline.
Neli PISCO SUAREZ retweeted
📈 POSITIVE Phase 3 Results in SJÖGREN’S DISEASE (@Amgen )
Dazodalibep met the primary endpoint of OASIZ 301, significantly improving ESSDAI scores at 48 weeks, with benefits seen from week 4.
Adverse events were mostly mild or moderate.
Neli PISCO SUAREZ retweeted
📊✅ ZANUBRUTINIB + RITUXIMAB IN FIRST-LINE MANTLE CELL LYMPHOMA
Phase III MANGROVE trial (BeOne) met its PFS endpoint comparing BRUKINSA + rituximab vs bendamustine + rituximab.
The chemo-free regimen reduced progression/death risk by 43% and spares patients ~2 yrs of infusions
Neli PISCO SUAREZ retweeted
🔵 In the PHASE 3 NEO-HEALER trial, ANBENITAMAB (KN026) + HB1801 achieved a pathological complete response rate of 62.4% (164/263) versus 51.2% (132/258) with trastuzumab + pertuzumab + docetaxel in patients with stage II–III HER2-positive breast #cancer .
Neli PISCO SUAREZ retweeted
🌞 UV radiation is present year-round, and UVA rays can penetrate clouds and windows, contributing to cumulative skin and DNA damage. Cold weather doesn’t mean low UV exposure. Applying broad-spectrum SPF 30–50 to exposed facial skin daily helps reduce cumulative UV damage.
Neli PISCO SUAREZ retweeted
💡 Editorial by Dr. Sana Al-Khatib:
Current guidelines require an LVEF ≤35% for ICD in primary prevention. Although CMR with late gadolinium enhancement helps identify risks in LVEF >35%, more randomized clinical trials are needed before changing clinical practice.
#Cardiology
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📊 ESC Congress Study:
In patients with an ejection fraction (EF) of 36-50% and myocardial scarring on magnetic resonance imaging (MRI), ICD implantation did not significantly reduce sudden cardiac death or ventricular arrhythmias compared to an implantable loop recorder.
Neli PISCO SUAREZ retweeted
#LongCOVID is not just common fatigue: it's a chronic multi-organ disease. Medical evidence confirms that the risk of vascular and neurological damage, as well as dysautonomia (such as PoTS), increases with each reinfection. Funding for biomarkers and treatments is needed.
Neli PISCO SUAREZ retweeted
Historical: @escardio launches 1st joint CVD & CKD Guidelines. Core pillar: "STAMP on CKD"
🩺 Screen: Mandatory (Class I) eGFR + UACR in CVD.
📊 Triage: Validated risk scores.
💊 Address: Early iSGLT2 & ACEi/ARB.
⚙️ Modify: Dose adjustment.
👥 Plan: Cardio-Nephro co-management.
Neli PISCO SUAREZ retweeted
🟡FDA approves Mounjaro to reduce CV risk in adults with type 2 diabetes. A cardiometabolic milestone expanding tirzepatide's reach beyond glycemic control, directly impacting patient survival and reducing major adverse cardiac events. #Cardiology #Diabetes #Pharma
Neli PISCO SUAREZ retweeted
🔵Biogen advances systemic lupus erythematosus research with Phase 3 trials (TOPAZ) evaluating litifilimab. This monoclonal antibody targets BDCA2 to block plasmacytoid dendritic cell pathways, reducing type I interferon production to control inflammation. #Immunology #Lupus
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📊🔵Glioblastoma update: Laminar Pharma hits LPLV milestone in its Phase 2b/3 trial. This oral, first-in-class drug modifies tumor cell membrane lipid composition via Melitherapy, reducing oncogenic signaling in aggressive brain tumors. #Neurology #Cancer #ClinicalTrials #MedEd
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🟡💉Biotech innovation: A thermostable diphtheria/tetanus vaccine inspired by the resurrection plant passes Phase 1. Using plant sugars like trehalose, it survives extreme heat, eliminating the cold chain to revolutionize vaccine access in developing nations. #Vaccines
Neli PISCO SUAREZ retweeted
🔹When facing status migrainosus—a severe migraine lasting over 72 hours—specialists often use targeted rescue therapies to break the cycle:
• IV Dihydroergotamine (DHE)
• Valproic acid infusions
• Corticosteroids
• triptans
• CGRP Monoclonal antibodies
• Nerve blocks
Neli PISCO SUAREZ retweeted
«He who studies medicine without books sails an uncharted sea, but he who studies medicine without patients does not go to sea at all.»
— Sir William Osler
Neli PISCO SUAREZ retweeted
👉 Herpes zoster is no longer a diagnosis we associate exclusively with older adults. The rise in cases among younger populations raises an important public health question: should vaccination eligibility criteria be updated to reflect the current epidemiological reality?
The increasing number of younger patients with shingles has prompted debate about expanding free vaccination eligibility.
mdsc.pe/4gTzaX0
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📊 An interesting finding in experimental oncology: psilocybin showed neuroprotective effects against chemotherapy-induced peripheral neuropathy, helping preserve mitochondrial transport in nerves. The next step is determining whether these effects can translate to patients.
More positive news on psychedelics: psilocybin doses before cancer chemotherapy protects neurons and helps prevent peripheral neuropathy in the experimental model @ScienceMagazine
science.org/doi/10.1126/scie…
science.org/doi/10.1126/scie…
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✅ The muscle–brain axis is fascinating: new research suggests that muscle-derived apelin may enhance hippocampal neurogenesis and plasticity through APJ and NMDA signaling, linking exercise to brain function and depressive symptoms. The biology behind exercise is surprising.
Que belleza el eje músculo-crebro un estudio reciente que demuestra cómo los músculos liberan la proteína apelin durante el ejercicio para comunicarse con el cerebro y reducir síntomas depresivos.
El artículo en Molecular Psychiatry revela que el apelin muscular aumenta la neurogénesis y plasticidad hipocampal vía receptores APJ y señalización NMDA, confirmando un eje músculo-cerebro.
El músculo es una glándula antidepresiva, ocúpala.