@PiresChemBioLab

Chemical Microbiology Group @ChemistryUVA, University of Virginia | Account managed by members of the group. https://xitter.cf/t.co/zIrbZKARM7

Joined August 2013
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  • Following98
  • Followers248
16Media
We present "The mycomembrane differentially and heterogeneously restricts antibiotic permeation" a fantastic collaboration led by @siegristpalmore biorxiv.org/content/10.1101/…

The mycomembrane differentially and heterogeneously restricts antibiotic permeation

The recalcitrance of Mycobacterium tuberculosis to antibiotic treatment has been broadly attributed to the impermeability of the organism’s outer mycomembrane. However, the studies that support this...

biorxiv.org
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Congratulations to our advisor Dr. Marcos Pires on being named a Dean's Research Fellow by the Graduate School of Arts and Sciences at UVA! as.virginia.edu/inaugural-cl… @ChemistryUVA #UVA #Pireslab #Science
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Congratulations to 4th year graduate student Rachita Dash on receiving the Littleton Glover Endowed Graduate fellowship for the 2024-2025 academic year. @ChemistryUVA @___Rachita___ #UVA #UVAchemistry #UVA
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Some of our graduate students learning about the latest advances in peptide science & presenting their work at the #37thEPS European #Peptide Symposium & 14th international peptide symposium in Florence, 🇮🇹. #peptide #EPS2024 #research #UVAchemistry #UVA
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Our summer undergraduate researchers enjoying #ACSFall2024. #ACSDenver #UVAChemistry #UVA
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Out in @AmerChemSociety chemical biology " A Chemical Approach to Assess the Impact of Post-translational Modification on MHC Peptide Binding and Effector Cell Engagement" pubs.acs.org/doi/epdf/10.102… Congratulations to all the authors.
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Out in @PNASNews a collaboration led by David Weiss & Craig Ellermeier "Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability" pnas.org/doi/10.1073/pnas.24… Congratulations to all the authors!
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Out in @ChemMedChem a collaboration led by @TheveninLab "Selective Recruitment of Antibodies to Cancer Cells and Immune Cell-mediated Killing via In Situ Click Chemistry" Congratulations to all the authors. chemistry-europe.onlinelibra…

Selective Recruitment of Antibodies to Cancer Cells and Immune Cell‐mediated Killing via In Situ...

This study presents a novel method using the pH-low insertion peptide (pHLIP) and click chemistry to selectively recruit antibodies to tumor cells, exploiting the tumor's acidic environment. This...

chemistry-europe.onlinelibrary.wiley.com
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This study in #ACSInfectiousDiseases presents a method to assess the accumulation of antibiotics real-time in live bacteria using bioluminescence. @PiresChemBioLab go.acs.org/9dI
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🎉Congratulations to third year graduate student Rachita Dash on winning the third year poster competition 🏆 @ChemistryUVA @___Rachita___
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With our wonderful collaborators led by the Kana group in South Africa 🇿🇦 in @eLife " A modified BCG with depletion of enzymes associated with peptidoglycan amidation induces enhanced protection against tuberculosis in mice" elifesciences.org/articles/8…

A modified BCG with depletion of enzymes associated with peptidoglycan amidation induces enhanced...

The new vaccine candidate for tuberculosis displays superior protection against disease when compared the currently available vaccine, and can potentially provide new options for global childhood...

elifesciences.org
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Out in @BioconjChem A study focused on the intestinal microbiota entitled “Noninvasive Analysis of Peptidoglycan from Living Animals” a story led by @ScienceavecKarl. We thank our wonderful collaborators @RutkowskiLab and @jutraslab pubs.acs.org/doi/10.1021/acs…

Noninvasive Analysis of Peptidoglycan from Living Animals

Abstract. The role of the intestinal microbiota in host health is increasingly revealed in its contributions to disease states. The host-microbiome interac

pubs.acs.org
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Out in @FrontImmunol we present "Targeted acidosis mediated delivery of antigenic MHC-binding peptides" a story in a wonderful collaboration with @TheveninLab led by @Joeykelly510 frontiersin.org/journals/imm…

Frontiers | Targeted acidosis mediated delivery of antigenic MHC-binding peptides

Cytotoxic T lymphocytes are the primary effector immune cells responsible for protection against cancer, as they target peptide neoantigens presented through...

frontiersin.org
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Check out our latest paper out in @ACS_Infectious led by @___Rachita___ We present a method to assess the accumulation of antibiotics, in real-time, in bacteria using bioluminescence! pubs.acs.org/doi/10.1021/acs…

Bioluminescence-Based Determination of Cytosolic Accumulation of Antibiotics in Escherichia coli

Abstract. Antibiotic resistance is an alarming public health concern that affects millions of individuals across the globe each year. A major challenge in

pubs.acs.org
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Check out this recent preprint identifying a novel L,d transpeptidase in C. difficile. This collaboration was led by our fantastic collaborators form the university of Iowa pubmed.ncbi.nlm.nih.gov/3855…

Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is...

Clostridioides difficile, the leading cause of antibiotic-associated diarrhea, relies primarily on 3-3 crosslinks created by L,D-transpeptidases (LDTs) to fortify its peptidoglycan (PG) cell wall....

pubmed.ncbi.nlm.nih.gov
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Check out our latest paper with our wonderful collaborators led by @AlisonCrissUVA group "Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation" Congratulations to the authors! journals.asm.org/doi/10.1128…

Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent...

Neisseria gonorrhoeae, the bacterium that causes gonorrhea, is an urgent global health concern due to increasing infection rates, widespread antibiotic resistance, and its ability to thwart protect...

journals.asm.org
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🎉Congratulations to Rachita Dash and Liora Wittle for securing the 2024 stepped-up and newly-arrived UVA Chemistry departmental service awards! 🏆 @___Rachita___ @ChemistryUVA
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🎓Congrats to our graduate students Joey Kelly and Karl Ocius for clinching the 2024 Hunt and Hecht UVA Chemistry departmental research awards! 🏆@joeykelly510 @ScienceavecKarl @ChemistryUVA
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🎉Exciting news from our lab! Karl has been awarded the Merck Underrepresented Chemists of Color award🏆. This recognition is well-deserved and highlights Karl's dedication and talent. Congratulations, @ScienceavecKarl! 🌟@ChemistryUVA @Merck
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Our latest manuscript "Measurement of Accumulation of Antibiotics to Staphylococcus aureus in Phagosomes of Live Macrophages" is live in @angew_chem dlvr.it/SzlfY0 Congratulations to all the authors! #UVAchemistry #Antibiotics #Permeability

Measurement of Accumulation of Antibiotics to Staphylococcus aureus in Phagosomes of Live Macroph...

Staphylococcus aureus (S. aureus) has evolved the ability to persist after uptake into host immune cells. This intracellular niche enables S. aureus to potentially escape host immune responses and...

pubmed.ncbi.nlm.nih.gov
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