@philiplabvandy

Working together at the frontier of cancer and immunology to advance cancer care, science, and education

philiplab.org
Joined August 2019
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Check out VUMC reporter piece on @jjroetman @CIR_AACR paper featuring amazing artwork by senior Halle Borowski @williamandmary created during the @ArtLab_Vandy @VI4Research Summer 2023 program! news.vumc.org/2023/11/17/tum…
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Check out other @artlab_vandy art at the Vanderbilt Fine Arts Gallery news.vanderbilt.edu/2023/08/…
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And a big thank you and shout out to @EricSkaar @kh_oliver @VI4Research @bwfund for creating and supporting this great program to bring scientists and artists together!
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Happy to present our latest paper in @CIR_AACR from @jjroetman, the whole @philiplabvandy team and Drs. Youngmin Lee and Ting-Fang Less @VUMCSurgery !
Cancer Immunology Research@CIR_AACR
6 Nov 2023
#OnlineFirst: Tumor-reactive CD8+ #Tcells enter a TCF1+PD1– dysfunctional state, by @jjroetman, Mary Philip et al. bit.ly/3MxT9w1 @immuno_minna @VUmedicine
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We hypothesize that peptide/MHC-TCR affinity may play a role in the divergent antigen-dependent differentiation we observed as self-shared antigens are usually lower affinity. 6/7
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We welcome feedback and suggestions, and a big thank you to our colleagues @VUMC_VCI @VUMC_Cancer @VUMCDIsoveries @Vandy_Biomed for all their support! 7/7
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@jjroetman developed a unique cancer model in which we could study CD8 T cell responses against tumor-specific antigens and self/shared antigens. 2/7
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Immune checkpoint blockade (ICB) can unleash T cell responses against tumors but can also cause unwanted toxicity, or immune-related adverse events (irAE), when T cells attack self/shared antigens in non-cancerous tissues. 3/7
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Happy Halloween🎃🎃🎃from the Dr. Seuss Lab @VUMC_VCI @VUmedicine @VanderbiltU
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Congratulations @JeffRathmell @ahasty4 @hasty4 @MakowskiLab @WellenLab! @VUMC_Cancer @VUMC_VCI
The Mark Foundation for Cancer Research
@TheMarkFdn
17 Oct 2023
Replying to @TheMarkFdn
Congratulations Endeavor team at Vanderbilt, University of Tennessee, University of Pennsylvania: Jeffrey Rathmell, Alyssa Hasty, Liza Makowski, Kathryn Wellen @jeffrathmell @hasty4 @MakowskiLab @WellenLab @vumc_cancer @PennMedicine
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Congratulations Andrea!
The American Association of Immunologists (AAI)
@ImmunologyAAI
10 Aug 2023
Congratulations to Dr. Andrea Schietinger, who received the AACR-Irving Weinstein Foundation Distinguished Lectureship. aacr.org/about-the-aacr/news… #Immunology
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We are excited to share our work published today in @NatImmunol by @MRudloffMSTP, the whole @PhilipLabVandy team @VUMCDiscoveries, and in collaboration with our fantastic computational biology collaborators @dbetel and his group @WeillCornell. 1/7 nature.com/articles/s41590-0…

Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before...

Nature Immunology - Rudloff et al. examine the kinetics of CD8+ T cell dysfunction/exhaustion. Tumor-specific CD8+ T cells in the tumor environment exhibit epigenetic modifications within hours,...

nature.com
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By dissecting the earliest epigenetic and gene expression programs that mediate dysfunction, we can design new strategies to prevent T cell dysfunction in patients with cancer. 6/7
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Last and most important, a big shoutout to all our amazing colleagues @VUMC_VCI @VUMC_Cancer @VUMCDIsoveries @Vandy_Biomed especially @JeffRathmell @SchietingerLab for all their support! 7/7
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