Constantly Curious. Mostly about Single Cells, Signaling, CRISPR and Cancer
Joined June 2020
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Fascinating work by @fabivf90 and @SendoelLab about the secret roles of microproteins
Our genome encodes > 7000 microproteins that have been previously ignored in genome annotations. How do these microproteins impact tissue function? Here, we use an in vivo single-cell CRISPR screen to systematically explore microprotein function. 1/9
biorxiv.org/content/10.1101/…
Peter F. Renz retweeted
Our genome encodes > 7000 microproteins that have been previously ignored in genome annotations. How do these microproteins impact tissue function? Here, we use an in vivo single-cell CRISPR screen to systematically explore microprotein function. 1/9
biorxiv.org/content/10.1101/…
Peter F. Renz retweeted
Spearheaded by the very talented @fabivf90 and another great collaboration with the Ellis lab, we used ribosome profiling to map microproteins in healthy epidermis and cancer, annotating more than 3000 novel ORFs. 2/9
interesting approach to look at clonal dynamics in cancer emergence. Particualrly impressed by the adoption of the Drake equation for cancer.
Goliath clades and in vivo tracking of clonal dynamics show three phases of UV-induced skin carcinogenesis biorxiv.org/cgi/content/shor… #biorxiv_cancer
Peter F. Renz retweeted
Goliath clades and in vivo tracking of clonal dynamics show three phases of UV-induced skin carcinogenesis biorxiv.org/cgi/content/shor… #biorxiv_cancer
I was happy to contribute a small part to this very innovative work on single-cell translatomic changes in the aging epidermis led by the incredibly talented @clarasdure . Check it out
How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse skin. 1/6
biorxiv.org/content/10.1101/…
Peter F. Renz retweeted
Congratulations to Peter (@PeterFRenz3) for being awarded the Skin Cancer Award 2024! Well deserved, we are very proud of you!
It was an honor and a pleasure to make a small contribution to help this lab grow. I'm sure the future is very bright for the Sendoel Lab.
It’s the end of an era as we bid a bittersweet farewell to @PeterFRenz3, one of the first members of our lab. Your commitment, spirit and enthusiasm have profoundly shaped our lab’s culture and have not only pushed scientific frontiers but also filled our days with lots of fun..
Peter F. Renz retweeted
It’s the end of an era as we bid a bittersweet farewell to @PeterFRenz3, one of the first members of our lab. Your commitment, spirit and enthusiasm have profoundly shaped our lab’s culture and have not only pushed scientific frontiers but also filled our days with lots of fun..
Peter F. Renz retweeted
Thank you @CD_AACR for highlighting our recent paper.
TNF Pathway Alterations Mediate Clonal Expansion and Tumorigenesis
aacrjournals.org/cdnews/news…
Peter F. Renz retweeted
Clonal expansions can remodel entire tissues even when they appear normal, but what mechanisms drive this? And how do these processes differ from tumorigenesis? Out @Nature, we identify distinct TNF programs during tumor evolution. 🧵
nature.com/articles/s41586-0…
Peter F. Renz retweeted
Der Signalweg TNF-α steuert die Umwandlung von Epithelzellen in aggressive Tumorzellen. Die Erkenntnis einer UZH-Studie könnte die Früherkennung und Behandlung von Haut-, Speiseröhren-, Blasen- oder Dickdarmkrebs verbessern: news.uzh.ch/de/articles/medi… @SendoelLab @uzh_irem
Peter F. Renz retweeted
The signaling pathway TNF-α drives the transformation of epithelial cells into aggressive tumor cells. This finding of a UZH study could help to improve early detection and treatment of cancers in skin, esophagus, bladder or colon: news.uzh.ch/en/articles/medi… @SendoelLab @uzh_irem
Peter F. Renz retweeted
The dark proteome encoded by more than 7200 annotated sORFs is redefining our understanding of the human genome.
Interested in how to detect microproteins? Check out Fabiola's recent review "No country for old methods".
sciencedirect.com/science/ar…
Peter F. Renz retweeted
Publication by the Sendoel lab (@uzh_irem, @UZH_en) with first author Umesh Ghoshdastider "Exploring the pan-#cancer landscape of #posttranscriptional regulation" @CellReports
bit.ly/3REmSXl #RNA #Bioinformatics
Peter F. Renz retweeted
Preprint by the Sendoel (@uzh_irem, @UZH_Science, @UZH_en), @moorlab (@ETH_BSSE, @ETH_en) & @s__ellis (@MaxPerutzLabs) labs "In vivo single-cell #CRISPR uncovers distinct #TNF-alpha programs in clonal expansion and #tumorigenesis" @biorxivpreprint
bit.ly/3pMhZ35
#cancer
Happy to share the latest pre-print from our lab. A single-cell CRISPR based investigation into clonal expansion and early tumorigenesis.
biorxiv.org/content/10.1101/…
A great team effort with @moorlab and @s__ellis
Excited to give a talk about our recent work from the sendoel-lab at #KSSingleCell23 @KeystoneSymp tomorrow.
"Tissue-wide Single-cell CRISPR Uncovers Distinct TNFa Modes in Clonal Expansion and Transformation in the Skin".
In collaboration with @moorlab and @s__ellis
Peter F. Renz retweeted
Great collaborative work with the Beyer group at ETH finally out!!
Inhibition of FGF and TGF-β Pathways in hESCs Identify STOX2 as a Novel SMAD2/4 Cofactor mdpi.com/925606 via @MDPIOpenAccess