@PepinLab

Associate Professor of Surgery at the Massachusetts General Hospital / Harvard Medical school. Reproductive and cancer biologist.

 Massachusetts General Hospital
pepinlab.com
Joined June 2021
  • Tweets146
  • Following133
  • Followers173
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Excited to share our lab's first preprint: we used spatial transcriptomics to dissect how aging disrupts the cycling ovary! 🧵 This was an incredible team effort w/ @jenngarrison @Tammyinlab @davidsebfischer AlisonKochersberger @RuthRaichur @sophiamszady
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.@kristenvbrown has spent nearly a decade reporting on consumer-DNA-testing companies and has recently written about the risks of sharing your data with genetic-testing companies. Tomorrow, she’s answering all of your questions in r/health on Reddit:
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I will be honored to coordinate this SSR New Investigator Bootcamp webinar tomorrow discussing the leadership, mentorship, and tenure for young investigators. Welcome register and join us. We will have three great panelist members, Dr. Jodi Flaws, Ripla Arora, and Humphrey Yao.
SSR@SSRepro23 Nov 2024
💡 Join us for our upcoming New Investigator Bootcamp webinar on "Leadership and Mentorship for Career Advancement and Tenure." 📅 Dec 11 | 12 PM ET 🎤 Dr. Humphrey Yao, Dr. Jodi Flaws, Dr. Ripla Arora Register today ➡️ brnw.ch/21wOUgb #EarlyCareer #Leadership
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Check out our new story! Mechanisms of innate and adaptive immune activation in cancer cells deficient in SMARCA4. Thank you to the multiple collaborators that made it possible. @neoviral @bengrbm @gonen_mithat @ChiappinelliLab science.org/doi/full/10.1126…

Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogeni...

SMARCA4 loss results in increased cancer cell–intrinsic immunogenicity, offering a therapeutic strategy to reverse immune evasion.

science.org
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New paper from our group in @Nature by @YiyunLin_YL @junkewang @KaileWang and team reporting the unexpected discovery of aneuploid epithelial cells (3%) in normal breast tissues from healthy women raising the question of when is cancer really cancer? nature.com/articles/s41586-0…
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Can Women Anti-Age Their Ovaries to Live Longer? elle.com/beauty/health-fitne…

Could Anti-Aging Your Ovaries Help You Live Longer?

Some promising evidence shows that ovarian health is tied to more than just your fertility.

elle.com
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Today! Come join us
SSR@SSRepro1 Nov 2024
🌟 Join us for the New Investigator Bootcamp webinar, "How to Put the ‘Fun’ in Funding: Applying, Maintaining Grant Funds and Managing your Finances!" 📅 Nov 13 @ 12 PM ET 🗣️ Dr. Chris Geyer, Dr. Paige Cooper, Dr. Stephanie Pangas, Dr. Susan Taymans 🔗 brnw.ch/21wOjux
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Woohoo, it's out! Our exciting publication in @PNASNews on genetic variants in kinesin genes that alter egg aneuploidy in humans. pnas.org/doi/10.1073/pnas.24…
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Check out our most recent work published in Communications Biology on harnessing the power of an ex vivo ovulation model to define the molecular mechanisms of follicle rupture. nature.com/articles/s42003-0… Congratulations Emily Zaniker and team!
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PepinLab retweeted
nature
@Nature18 Oct 2024
AlphaFold reveals the intimate details of the molecular meet-cute between sperm and eggs go.nature.com/3YqKdif
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Each month an #egg is ovulated from the #ovary, starting the journey of reproduction. But how does ovulation occur?🥚 Our latest work in @NatureCellBio led by @LastChrisThomas and @Tabea_Marx, describes the control of #ovulation using live imaging. bit.ly/3Ya8dEL (1/7)
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Happy publication day for us! Labor of love with @CoffmanLab #TLS #ovariancancer @UPMCHillmanCC @PittTweet The activity of tertiary lymphoid structures in high grade serous ovar... sciencedirect.com/science/ar…
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Data integrity concerns flagged in 130 women’s health papers — all by one co-author nature.com/articles/d41586-0…

Data integrity concerns flagged in 130 women’s health papers — all by one co-author

Nature - Some of the studies listed in a peer-reviewed paper as potentially problematic have been included in analyses that could inform clinical practice.

nature.com
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Making Eggs Without Ovaries, by @NikoMcCarty asimov.press/p/eggs?r=hzuy&u…

Making Eggs Without Ovaries

It may soon be possible to make human eggs from stem cells, thanks to advances in a technology called in vitro oogenesis.

asimov.press
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Excited to share my final paper as a postdoc with @NUDuncanLab, now on BioRxiv! Grateful to @GCRLE1 for funding this high-risk project and for fostering a network of reproductive biologists working on ovarian aging biorxiv.org/content/10.1101/…

Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse

The female reproductive system is one of the first to age in humans, resulting in infertility and endocrine disruptions. The aging ovary assumes a fibro-inflammatory milieu which negatively impacts...

biorxiv.org
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As an immigrant to the United States, along with many members of my lab, I feel compelled to reiterate that we are working on the development of non-surgical contraceptives for the humane treatment of cats, not recipes.
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Excited to share that my latest research on rejuvenating aged oocytes has just been published in @NatureAging with @SpringerNature! 🌟 Read here: xitter.cf/NaturePortfolio/status…
Nature Portfolio
@NaturePortfolio9 Sep 2024
Aged mouse oocytes appear to improve their developmental potential when implanted in follicles from young mice, according to a study in @NatureAging. This research highlights the importance of the follicular microenvironment in ovarian aging. go.nature.com/3MCn1Xp
This is figure 6, which shows restored mitochondrial fitness in aged oocytes cultured in young r-follicles.

ALT This is figure 6, which shows restored mitochondrial fitness in aged oocytes cultured in young r-follicles.

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Hormone-free infertility treatment....well, here we are finally...it's a clinical reality!! 20 years ago, our old IVM alliance: myself, @jeremygthompso2, Johan Smitz and @MdevosMD made this our aspirational goal. Now Dr Lan Vuong and @TuongMHo got there!!
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The end of menopause: would women be healthier and happier if they menstruated for ever? | Menopause | The Guardian theguardian.com/society/arti…

The end of menopause: would women be healthier and happier if they menstruated for ever?

The ovaries affect everything from metabolism to mood – so some scientists are on a quest to slow their ageing process

theguardian.com
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Great summary of the inflated expectations of age reversal. It’s certainly true of reproductive aging. How can anyone make claims when we barely understand the fundamentals. embopress.org/doi/full/10.10…

Inflated expectations: the strange craze for translational research on aging

EMBO Reports - The geroscience research program of the last decade has entailed a shift of focus in research on aging, away from understanding its underlying biology and towards translation into...

link.springer.com
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