Postdoc in the Chromatin and Development lab at the @MRC_LMS. Tweets are 50% science, 50% randomness.
Joined July 2013
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Paul Chammas retweeted
Hady Habib’s reaction after winning his 1st round at Australian Open
Imagine being the 1st from your country to qualify for a Slam
He did that 2 days ago
Imagine being the 1st from your country to win a Slam match
He did that today
For Lebanon 🇱🇧❤️
Happy to share our latest #preprint showcasing the work done during my postdoc in the lab of @MPercharde at the @MRC_LMS. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state. biorxiv.org/content/10.1101/… (1/8)
Noxa KO in ESCs reduces Dux-dependent apoptosis and is even upregulated in the muscular dystrophy, FSHD, which is driven by DUX4 mis-expression. It’ll be interesting in future to look at therapeutic NOXA reduction in FSHD myoblasts. (7/8)
Tl;dr, MERVL is an integrator of multiple TFs to drive the 2C-like state, and drives some yet not all totipotency features. In contrast Dux-dependent toxicity is MERVL-independent and involves Noxa-induced apoptosis. Big thanks to all involved! @BryonyLeeke @Less_Sepulveda (8/8)
Paul Chammas retweeted
Very excited to announce this 1 day symposium on 7th Dec @MRC_LMS: Stem Cell-Based Modeling of Reproduction & Development. Fantastic speaker line up and topics inc. implantation, diapause, infertility, maternal-fetal interactions & more. Pls RT!
Register:
symposia.org.uk/courses/stem…
Paul Chammas retweeted
Still speechless! Past and current lab members came to Barcelona from all-over the globe for the 20th year anniversary of our lab at @CRGenomica @the_prbb !
Paul Chammas retweeted
Quick break from leave for a lab coffee @MRC_LMS - the view alone makes it worth a visit! Also some lab training in baby handling 😉
Paul Chammas retweeted
Want to dive deeper into she splicing reaction and code? 🔍 Check out the review we wrote with @JuanValcarcel5 and @MalgorzataRoga1 in @NatureRevGenet!! go.nature.com/3BFIlqc
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects go.nature.com/3BDfNO4 #Review by @MalgorzataRoga1, @clau_vivori & Juan Valcárcel @CRGenomica @UPFBarcelona @TheCrick
Paul Chammas retweeted
CNN report on Lebanon’s fantastic trip to the finals despite the country’s circumstances since 2019.
Very happy to have contributed to the first Percharde lab paper!! Massive effort by @XieSheila and all authors involved!!🥳🥳
🌟V.happy to update this thread and say our lab's 1st paper is now published. We describe unexpected roles for the nucleolus in gene and transposon regulation in early development.
Thanks to @GenesDev for a fast&fair process and to helpful reviewers 1/4
genesdev.cshlp.org/content/e…
Paul Chammas retweeted
Who's got a chance to win anything in winter Olympics other than Northern countries? We need another type of Olympics that gives a natural advantage to the South. Like the ability to use spices correctly or require 14 stamps for a government application.
Paul Chammas retweeted
🚨We're hiring! Postdoc position (computational or wet lab) available in our lab @MRC_LMS. #Transposon and chromatin regulation in human dev't/disease. Fun people&projects, soon to be in a new building! #PleaseRT International/EU always welcome 🇪🇺🌎🇬🇧
bit.ly/3FXgeC7
Paul Chammas retweeted
🚨NEW STORY 🚨Very excited to share the first preprint from our lab @MRC_LMS !! biorxiv.org/content/10.1101/… We reveal an intriguing requirement for nucleolar maturation for repression of Dux and the 2-cell (2C)-like state. (1/9) 🧵
Join our lab!! Fun science with fun people!
@FerranGLl @BryonyLeeke @MPercharde and other non-twitter folk 😄🧬🔬
Silly/hiring season is here! New postdoc position in our lab @MRC_LMS @imperialcollege in London. Come study chromatin and transposon regulation in development and disease. V.interested in people with experience with hESCs/iPSCs or bioinformatics. *Pls RT* tinyurl.com/urt46u43
