@PaulTalbert10

Chromatin geneticist HHMI at Fred Hutchinson Cancer Center

Joined March 2019
  • Tweets47
  • Following42
  • Followers46
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Our recent review on genome packaging in giant viruses: pubmed.ncbi.nlm.nih.gov/3777…

Giant variations in giant virus genome packaging - PubMed

Giant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase...

pubmed.ncbi.nlm.nih.gov
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Oops, that didn't work cell.com/trends/biochemical-…

Giant variations in giant virus genome packaging

Giant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase...

cell.com
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Human satellite centromere expansions and contractions can be measured in ~20 cell generations and depend on RAD52 and PIF1, suggesting break-induced replication biorxiv.org/content/10.1101/…

Expansion of human centromeric arrays in cells undergoing break-induced replication

Human centromeres are located within α-satellite arrays and evolve rapidly, which can lead to individual variation in array lengths. Proposed mechanisms for such alterations in lengths are unequal...

biorxiv.org
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Paul Talbert retweeted
Nick Irwin@dinokaryon22 Sep 2023
Excited to share our manuscript about how we studied the function and evolution of giant viral histones to understand the origin of the nucleosome biorxiv.org/content/10.1101/… (1/10)
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For anyone who follows me or otherwise happens to read my tweets, it appears that my account was hacked in April. I apologize for the resultant spam, and have changed my password. I am not on here often and was not aware until now.
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This project is 🔥🔥🔥 @mehrabmunna27 @alexeymosobl @Qatarcrywrld @sh7825 @TsTsybenova @Vladimi83888799 @adaduck11 @BuiHung10799114 @kianichaharlang @alsaadhus
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This project is 🔥🔥🔥 @btcracer @lotsoftips @MohtasimBilla15 @Sentham55941626 @SportsHobbyist @_magic_mushroom
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One of my top tokens! @RedBarron1121 @Tric0ma @Jeffoy88 @Winifre70914203 @mihaylord @cryptoalexevz @Terraandluna @HemingwayClint @CryptoKing_Tony
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One of the best projects in the space! @Jpartyon @joe293312 @AlexLee5354 @bigboy19917 @vdramaliev @Ana1288770 @RajgarhiaShyam @tacwzr @BigAnnaGao520
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Genuinely curious: do the Texas republicans have a rationale for why voting after midnight is okay if the rules say they can't? #UniswapScam
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Just lost a bunch of USDC an hour ago cause there was an exploit on @Uniswap from when I bought magic earlier today... #UniswapExploit #UniswapHack
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🚨#UniswapHack #UniswapExploit🚨 If you have interacted with UniSwap recently, please revoke any token approvals.
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My review of the centromere drive model 20 years after it was proposed is out in Current Opinions in Genetics and Development. sciencedirect.com/science/ar…
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Check out our investigation of Marseillevirus chromatin in Molecular Cell. sciencedirect.com/science/ar…
Metagenomic projects have uncovered a wealth of viral histones. What do they do? epigeneticsandchromatin.biom…

Viral histones: pickpocket’s prize or primordial progenitor?

Epigenetics & Chromatin - The common histones H2A, H2B, H3, and H4 are the characteristic components of eukaryotic nucleosomes, which function to wrap DNA and compact the genome as well as to...

link.springer.com
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Interesting story of episodic duplication, loss and replacement a fundamental enzyme across all three domains of life.
Albert Erives 🧬@AlbertErives2 Aug 2019
My paper with University of Iowa UG research assistant Oliver Vickman just came out at PLoS ONE! #NADK #LUCA #LECA #metabolism #Nematoda journals.plos.org/plosone/ar…

Episodic evolution of a eukaryotic NADK repertoire of ancient provenance

NAD kinase (NADK) is the sole enzyme that phosphorylates nicotinamide adenine dinucleotide (NAD+/NADH) into NADP+/NADPH, which provides the chemical reducing power in anabolic (biosynthetic) pathwa...

journals.plos.org
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