The photomicrograph shows a distended tubule with an intratubular crystalline cast with agryophilia. While crystalline casts can be seen from calcium phosphate, calcium oxalate and others, the presence of agryophilia on sliver stain is characteristic for 2,8-Dihydroxyadenuria (DHA) crystals. 2,8-DHA is a rare, autosomal recessive trait caused by a genetic deficiency in adenine phosphoribosyltransferase (APRT). Accurate diagnosis is critical (especially in those with limited chronicity) as treatment exists that can ameliorate renal damage in some patients. And, in patients with undiagnosed disease who undergo transplant, the disease will reoccur unless pharmacologic intervention is initiated. Of note, agryophilic, birefringent crystals can also be seen in patients exposed to triamterene which should always be excluded before a diagnosis of 2,8-DHA is rendered. #renalpath #kidneypath #pathology #renal #pathtwitter