@Path_Wei

Associate Clinical Professor, Department of Pathology, UC Davis Medical Center

 Sacramento, CA
Joined February 2018
  • Tweets2K
  • Following338
  • Followers325
Dongguang Wei retweeted
JClinPath_BMJ
@JClinPath_BMJOct 17
🔬 When polarity turns upside down… A fascinating and apparently novel morphological finding in Crohn’s disease: reverse polarity in pseudopyloric metaplasia. Reverse polarity is well described in several neoplasms and a few non-neoplastic disorders—but its occurrence in pseudopyloric metaplasia in Crohn’s disease appears to be previously undescribed. ✨ A reminder that morphology still has the power to surprise us. For pathologists, sometimes the most interesting discoveries are hiding in the orientation of a nucleus. 📖 Gupta S, Bojanapu S, Pai SA. Reverse polarity in pseudopyloric metaplasia in Crohn’s disease. J Clin Pathol. 2025;78:651–652. Link to the paper: bit.ly/4cTdsRw
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Extra-nodal Rosai Dorfman disease shows overlapping features with IgG4-related fibrosclerosing disease - storiform fibrosis and inflammation. The S100 stain highlights emperipolesis with nuclear (short arrows) and cytoplasmic staining; engulfed cells are negative (long arrows).
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Dongguang Wei retweeted
Int J Surg Pathol@IJSPjournalOct 13
Histologic features favoring CMV hepatitis in liver allograft biopsies with overlapping rejection-type injury ➡️Microgranulomas ➡️Neutrophilic microabscesses Difficult topic, covered by IJSP. Read more here 👉🏼 tinyurl.com/5enfmwv3 #PathTwitter #GIPath #MedicalLiverPath
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Just a bread and butter case: with better control of HIV disease it is easy to forget about Kaposi sarcoma - this example with hyaline globules. (erythrophagolysosomes).
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Amyloid may be deposited anywhere in the human body - the colon is not an exception. These ones were taken out as polyps!!! Enjoy!
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Dongguang Wei retweeted
Pathological Society@pathsocOct 14
Latest Editor’s Choice article in #TheJournalOfPathology (November 26 issue): pathsocjournals.onlinelibrar… #Hepatoblastoma #Pathology #PathSoc #PathTwitter
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Dongguang Wei retweeted
Ankur Sangoi@slusagarOct 6
nice recent @IntSocUropath consensus on urachal neoplasms staging these is still a challenge! (I typically include both Sheldon and Mayo in my reports)
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It's a vintage article from Modern Pathology, but keratin expression in schwannomas is an "always" pitfall! IYKYK! pubmed.ncbi.nlm.nih.gov/1635…
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Check out the peculiar vacuolated cell change in this banal fundic gland polyp. This change, possibly related to proton pump inhibitors, sometimes results in concern for in situ signet ring cell carcinoma, which appears different (the high magnification image).
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Dongguang Wei retweeted
JClinPath_BMJ
@JClinPath_BMJOct 10
🔬 When polarity turns upside down… A fascinating and apparently novel morphological finding in Crohn’s disease: reverse polarity in pseudopyloric metaplasia. Reverse polarity is well described in several neoplasms and a few non-neoplastic disorders—but its occurrence in pseudopyloric metaplasia in Crohn’s disease appears to be previously undescribed. ✨ A reminder that morphology still has the power to surprise us. For pathologists, sometimes the most interesting discoveries are hiding in the orientation of a nucleus. 📖 Gupta S, Bojanapu S, Pai SA. Reverse polarity in pseudopyloric metaplasia in Crohn’s disease. J Clin Pathol. 2025;78:651–652. Link to the paper: bit.ly/4cTdsRw
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Langerhans cell histiocytosis (LCH) can present as colorectal polyps in adults and is generally indolent - analogous to to eosinophilic granuloma. Pediatric gastrointestinal LCH, in contrast, is often devastating. pubmed.ncbi.nlm.nih.gov/3889…
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This example of colonic Kaposi sarcoma has both spindle cell and lymphangioma-like areas. It even had perfect hyaline globules (indicated).
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Dongguang Wei retweeted
Tim Bracey@drtimbraceyOct 4
1/3. Primary anal canal adenocarcinoma in an elderly man. Modern classifications recognise 4 subtypes: mucosal, extramucosal anal gland, extramucosal fistula-associated, and extramucosal non-anal gland/non-fistula-associated adenocarcinoma. What subtype do you favour here?
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Dongguang Wei retweeted
Histopathology@Histo_JournalOct 3
A large population-based study showing that tumour deposits (TD) in colorectal carcinoma have inependent prognostic significance. The authors suggest that TD may represent a distinct metastatic phenotype. #GIPath #Xpath #Openaccess doi.org/10.1111/his.70297

Tumour deposits are associated with increased metastatic risk in colorectal cancer: a population‐...

In this population-based cohort of 3505 patients with colorectal cancer without distant metastases at diagnosis, tumour deposits are independently associated with an increased risk of distant...

onlinelibrary.wiley.com
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Gastropathy associated with losartan with parietal cell loss mimics autoimmune gastritis but there is no enterochromaffin-like cell hyperplasia. There is only mild antral inflammation. This case has a collagenous gastritis pattern of injury. Note the pseudopyloric metaplasia.
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Dongguang Wei retweeted
JClinPath_BMJ
@JClinPath_BMJSep 17
🔬 When polarity turns upside down… A fascinating and apparently novel morphological finding in Crohn’s disease: reverse polarity in pseudopyloric metaplasia. Reverse polarity is well described in several neoplasms and a few non-neoplastic disorders—but its occurrence in pseudopyloric metaplasia in Crohn’s disease appears to be previously undescribed. ✨ A reminder that morphology still has the power to surprise us. For pathologists, sometimes the most interesting discoveries are hiding in the orientation of a nucleus. 📖 Gupta S, Bojanapu S, Pai SA. Reverse polarity in pseudopyloric metaplasia in Crohn’s disease. J Clin Pathol. 2025;78:651–652. Link to the paper: bit.ly/4cTdsRw
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Pathology is not local. It is global! If you are interested in expanding your pathology knowledge, whatever your practice setting, check out the free curriculum and other resources that the Open Pathology Education Network has to offer. open-pathology.org/ #pathology
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Dongguang Wei retweeted
Tim Bracey@drtimbraceySep 14
1/2. Don’t think I’ve seen this pattern in rectal mucosa before! HSIL (AIN3) with striking replacement of anorectal crypt epithelium, producing multiple rounded dysplastic crypt profiles on low power. The appearance brought to mind cervical CIN3 with gland/crypt involvement.
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Check out a recent Letter to the Editor: Immunohistochemical Expression of FGFR2b (FPR2-D Antibody) in Colorectal Cancers Read more here 👉 10.5858/arpa.2025-0640-LE #CAP #Archives #GIPathology #Pathology #ColorectalCancer
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Dongguang Wei retweeted
Sumanta Das@SumantaDas_7Sep 1
#PathX #PathTwitter #SurgPath #GIPath Gastric adenocarcinoma with enteroblastic differentiation
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