@PatDotPy

Bioinformatics & Computational Biology @biosens8

 United States
Joined May 2018
  • Tweets18
  • Following87
  • Followers16
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Replying to @NousResearch
Hermes said replying to this counts as social engineering
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Replying to @NousResearch
Ok
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If Dario and Sam really wanted to slow down the pace of AI, they would move their research to a university.
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Happy Friday!
Unsloth AI
@UnslothAIAug 14
Qwen3.8-27B can now be run locally! ✨ Run on 17GB RAM via Unsloth Dynamic GGUFs. Qwen3.8-27B is by far the strongest model for its size. We also uploaded NVFP4 quants. GGUF: huggingface.co/unsloth/Qwen3… Guide: unsloth.ai/docs/models/qwen3…
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Pat Lally retweeted
Qwen Developers
@QwenDevsAug 11
Got you covered bro, 27B is landing this week
Wayne Lowry
@wikiwayneAug 10
Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b Qwen 3.8 27b We believe in you!!!!
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👀
Synthetic Sciences (YC W26)
@SynScienceJul 5
Introducing OpenScience. A better, open-source Claude Science. • Any model: GLM, Kimi, DeepSeek, Claude, GPT, your own fine-tune. Switching is one flag. • 250+ research skills across ML, comp bio, cheminformatics. All readable, editable, extensible. • No throttling, no gatekeeping, no one vendor deciding what science is okay. • Native Atlas integration: many agents, one shared reproducible research graph. • Runs on your infra. Your data stays yours. Scientific AI should be open. One company shouldn't own the tools the rest of us discover with, or decide who gets to.
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Replying to @anshulkundaje @vijaypande
A used RTX 3090 and see how far you can get with the ~30B param class of models :)
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"I'm trying to free your mind Neo. But I can only show you the door. You're the one that has to walk through it"
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Replying to @dionizije_fa @sudoingX
Is the 3.6 score actually run through local hardware? (Eg q4 k m, maybe kv quant)
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Replying to @Teknium
I wake up The feature I thought about last night already exists
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decided to move the hallucinations on-prem
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Excited to release BoltzGen which brings SOTA folding performance to binder design! The best part of this project has been collaborating with many leading biologists who tested BoltzGen at an unprecedented scale, showing success on many novel targets and pushing its limits! 🧵..
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Pat Lally retweeted
owl
@owl_posting2 Oct 2025
Ask not why would you work in biology, but rather: why wouldn't you? owlposting.com/p/ask-not-why… openai/gemini gave this essay an A- for evocative imagery. claude gave it a C- for being emotionally manipulative. both are probably right. i feel a little sick re-reading it

Ask not why would you work in biology, but rather: why wouldn't you?

1.9k words, 9 minutes reading time

owlposting.com
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Last month, @PatDotPy defended his PhD dissertation! Pat’s work studied E. coli Transcription Factors at multiple resolution scales & provided novel insights into the spectrum of TF binding (more details soon)! He is now building NGS Analysis Pipeline Services for @BU_PDC!
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Replying to @jankosinski
Apologies if you’ve answered this already but have you tried this with a “nonspecific” sequence? Might give that a shot later myself but curious what it would find
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When a fly is buzzing around the lab
Loving our new OT2 liquid handler! Looking forward to seeing what else it can do! @opentrons #Automation #NGS #HighThroughputBiology
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