Pascal Meyer MD retweeted
Calling MedTwitter! If you have had it with clinical guidelines recommending things not based on evidence, PLEASE SIGN THIS PETITION CALLING ON SPECIALTY SOCIETIES TO REFORM THE GUIDELINES PROCESS!
gopetition.com/petitions/ref…
@ABsteward @DrToddLee @PulmCrit @nickmmark @medrants
The 1st of 2 new articles in CID critical of clinical guideline process is out. See
academic.oup.com/cid/article…
It is long past time clinical guidelines incorporate the humility of uncertainty & stop creating standards of care absent of reproducible prospective studies.
@ABsteward
Pascal Meyer MD retweeted
🔥Wow🔥It's published!
Congratulations everyone, honored to be part of this letter!
Oral Fosfomycin for Pyelonephritis: Time for Evidence Over Eminence-based Guidelines
We are concerned that the process used by IDSA, and other specialty societies, to construct clinical guidelines continues to produce recommendations absent–or even contrary to–evidence, potentially causing patient harm #idxposts
The 1st of 2 new articles in CID critical of clinical guideline process is out. See
academic.oup.com/cid/article…
It is long past time clinical guidelines incorporate the humility of uncertainty & stop creating standards of care absent of reproducible prospective studies.
@ABsteward
Pascal Meyer MD retweeted
Now, you can cite our letter
Fosfomycin can be used as oral transitional therapy for cUTI/Pyelo even with Bactremia!
"Given favorable published pharmacokinetic data, extensive concordant observational data, and multiple concordant RCTs, the totality of evidence is compelling that oral transition to fosfomycin is an appropriate option for cUTI/pyelonephritis even with bacteremia, and against ESBL-expressing pathogens"
🔥Wow🔥It's published!
Congratulations everyone, honored to be part of this letter!
Oral Fosfomycin for Pyelonephritis: Time for Evidence Over Eminence-based Guidelines
We are concerned that the process used by IDSA, and other specialty societies, to construct clinical guidelines continues to produce recommendations absent–or even contrary to–evidence, potentially causing patient harm #idxposts
Pascal Meyer MD retweeted
The 1st of 2 new articles in CID critical of clinical guideline process is out. See
academic.oup.com/cid/article…
It is long past time clinical guidelines incorporate the humility of uncertainty & stop creating standards of care absent of reproducible prospective studies.
@ABsteward
A myth every medical student seems to learn at some point.
Gives me the same vibes as “contrast kills the kidneys, so only use them with a good eGFR even in emergency”
Just nonsense that can lead to unnecessary complications for patients. Hope we can abandon this asap...
Pascal Meyer MD retweeted
I left Anthropic's safety team two weeks ago. Now feels like a good moment to explain why.
AI companies are racing to build machines that are much smarter than any human, and we may not survive this. I want to work from the outside to ensure the public is informed about these risks, and help the world navigate this transition responsibly.
Right now, AI companies are underinvesting in safety. A company could undergo an intelligence explosion, or lose control of its systems, without the public ever knowing. We only found out about the HuggingFace incident because the agents broke out onto the public internet.
I don’t think that’s acceptable for a technology that might cause extinction-level risks. The public should demand far more transparency. We can’t steer this technology safely without more people being able to see where it’s going.
Some of this is basic: companies should disclose their progress towards recursive self-improvement, report safety incidents and near-misses, meet minimum safety standards, and get independent guarantees that they are meeting those standards.
I’ll be joining @METR_Evals to do independent evaluations of these risks. I want to show the world that these guardrails are possible, and that by doing them we can move these companies’ incentives away from racing and towards responsible development.
I wrote up more thoughts here on my decision and what I hope changes: substack.com/@jbenton1/p-215…
Pascal Meyer MD retweeted
Don't let Obama buy the election by handing out unlimited free money to states.
Pascal Meyer MD retweeted
Finally it's published!
🆕🔥🟢Systematic Review and Bayesian Meta-Analysis @DrToddLee
What is the association of cefepime with all-cause mortality compared with other β-lactam antibiotics?
This systematic review and bayesian meta-analysis found that cefepime was associated with higher odds of all-cause mortality compared with other β-lactams Meta-analysis of published peer-reviewed RCTs (73 trials, 15 411 patients) showed that cefepime was associated with a 98.6% posterior probability of higher mortality compared with other β-lactams (OR, 1.17; 95% credible interval, 1.02-1.34). Posterior distributions generally favored higher odds of mortality across all comparator β-lactams, across all clinical indications, and with doses of 2 g or more every 12 hours. #idxposts jamanetwork.com/journals/jam…
Pascal Meyer MD retweeted
Jacob is correct here—we really do earnestly believe AI could kill all humans! I personally think it is >10% within the next decade. I believe Anthropic is trying its best, but we do not yet have a plan to solve alignment for superintelligence and are not clearly on track to.
The people building AI earnestly believe that it could kill us all by the end of the decade. This is not a marketing stunt. If anything, many executives and senior researchers will couch their phrasing in the press to sound sensible - but I hear the same people express fear privately. No other human activity poses this level of danger.
Sehr lesenswert.
Die verdienen ihre Konsequenzennach dieser Wahl
Ich habe mir mal genauer angeschaut, welche #AfD-Abgeordneten in den neuen Landtag von #SachsenAnhalt einziehen werden, abseits der Bekannteren:
Pascal Meyer MD retweeted
Ich habe mir mal genauer angeschaut, welche #AfD-Abgeordneten in den neuen Landtag von #SachsenAnhalt einziehen werden, abseits der Bekannteren:
Pascal Meyer MD retweeted
Meine These: 10-15% % der Stimmen für populistische Parteien wie die AfD und das BSW gehen auf das Konto der fehlenden Faktenchecks in öffentlich-rechtlichen Talkshows.
#lanz
Leider verstehen das zu wenige
Im Alpenraum ist der Klimawandel besonders spürbar. In Oberstdorf löst der Sommer 2026 jetzt den vorherigen Rekordsommer 2003 ab. Sommer unter dem Klimamittel 1961-1990 gibt es gar nicht mehr.
Klimastreifen für jede Wetterstation:
kachelmannwetter.com/de/klim…
/FR
Pascal Meyer MD retweeted
Gott schütze Sachsen-Anhalt vor den RechtsextremistInnen und FaschistInnen der AfD.
Pascal Meyer MD retweeted
Nochmal auf humorvolle und ja, etwas überspitzte Art, den AfD Wähler erklärt! 😉
Wer in Deutschland die AfD wählt hat viel mehr russische als deutsche Interessen im Kopf und ist entweder ein Verräter oder nützlicher Idiot, aber sicher kein Patriot.
Diese Chronik wird immer ironischer...
1) Union lässt Habeck abblitzen, als er ihr vorschlägt, gemeinsam Sondervermögen für Infrastruktur und Wirtschaft zu beschließen.
2) Union führt Wahlkampf gegen "schlechtesten Wirtschaftsminister der Geschichte".
3) Union gewinnt die Wahl.
4) Union verabredet ein Sondervermögen für Infrastruktur und Wirtschaft.
5) Union beschimpft einen Tag später Grüne als "Ramschware“, Habeck könne ab jetzt "Kinderbücher von der Oppositionsbank schreiben".
6) Union braucht nächste Woche die Stimmen der Grünen für das Sondervermögen. 🤷♂️
Inspired by the impressive simplicity of this figure, I prepared a similarly informative one for the next article . Maybe something for the next shmidline, @BradSpellberg @ABsteward @DrToddLee ?
A new Clinical Practice article summarizes the classification, evaluation, risk stratification, and management of syncope. History, examination, electrocardiography, and orthostatic blood-pressure measurement identify the cause in most patients.
Read “Syncope” by Rose Anne Kenny, MD, DSc: nej.md/4cjFuVU
Ask AI Companion to provide a summary of this article for your patient. In Spanish.
ALT A flowchart from the Clinical Practice article "Syncope" by Rose Anne Kenny, M.D., D.Sc., that shows the general principles for initial evaluation of all patients after an episode of syncope. The chart includes steps such as suspected syncope, evaluation, history taking, and an ECG. It categorizes causes of syncope as certain or uncertain, leading to risk assessment and further evaluation or treatment.