@PancPathologist

Pancreatic/Gastrointestinal Pathologist. T/RT ≠ medical advice

Pittsburgh, PA
Joined April 2016
A tweetorial on our study (gastrojournal.org/article/S0…). But, first a case: Young female w/ a 1.9 cm incidental pancreatic cyst. No concerning features, but KRAS, TP53 and SMAD4 mutations on molecular testing. Surgical resection: #IPMN w/ a small #PancreaticCancer. #Pathology #GIPath
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Aatur Singhi, MD PhD retweeted
Nichole Borchard faced one of the rarest cancer diagnoses a woman can receive. The Nichole Borchard Foundation - created to change the narrative for patients - is now partnering with NANETS to fund new research into high-grade NEC. Up to $100K, applications open tomorrow. Details at nanets.net/research/research…
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Aatur Singhi, MD PhD retweeted
Robotic vs. Laparoscopic Cholecystectomy: What Our New Multihospital Study Reveals At PittSurgery, we're always asking the same question before every operation: what's actually best for this patient? A new study led by @AmerZureikatMD  analyzing 1,828 patients across 8 hospitals (2020–2021), offers some of the clearest evidence yet on when robotic surgery adds real value in gallbladder removal — and when it doesn't. Key findings: -Robotic cholecystectomy (RC) showed lower rates of adverse outcomes overall (3.3% vs. 8.7% for laparoscopic) and shorter hospital stays. -The advantage was concentrated in high-risk cases (Nassar score ≥7) and patients with elevated BMI — in these groups, laparoscopic surgery carried significantly higher odds of complications or conversion to open surgery.  -For low/intermediate-risk patients with lower BMI, both approaches performed comparably.  -The catch: RC cost roughly $2,200–$2,400 more per case than LC, regardless of risk level.  Dr. Zureikat's team also validated a preoperative risk calculator (AUC ~0.74–0.75) to help surgeons match the right approach to the right patient. Robotic surgery isn't universally "better" — its clinical edge shows up specifically in technically complex or higher-risk cases. For most routine cholecystectomies, laparoscopic surgery remains equally safe and far more cost-effective. Smarter patient selection — not blanket adoption of new technology — may be the real path to better outcomes and resource stewardship. What's your take: should risk-stratified guidelines like this shape hospital purchasing and OR scheduling decisions? JAMA Surgery: Published today Published Online: September 16, 2026. doi:10.1001/jamasurg.2026.4128 #PittSurgery #JAMASurgery #RoboticSurgery#LaparoscopicSurgery #Cholecystectomy#SurgicalInnovation #PatientSafety#ClinicalResearch #EvidenceBasedMedicine#SurgicalOutcomes
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Aatur Singhi, MD PhD retweeted
Pancreatic tumors are highly heterogeneous and immunosuppressive. But is immune resistance imposed across the whole tumor - or built locally by distinct cancer-cell states? I’m incredibly excited to share our new paper, now out in @Nature! 🎉 doi.org/10.1038/s41586-026-1… (1/7)
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Aatur Singhi, MD PhD retweeted
📣Join CGA-IGC and the @AmCollegeGastro for an expert-led webinar with Fay Kastrinos, MD, on the evolving management of hereditary pancreatic cancer risk. 🩺 📅 Thursday, September 24 ⏰ Noon ET / 9:00 am PT or 8:00 pm ET / 5:00 pm PT This session will provide an updated overview of: 🔹 Surveillance strategies for high-risk individuals 🔹 Findings encountered during pancreatic cancer screening 🔹 Interpretation of pancreatic abnormalities 🔹 When closer follow-up or intervention should be considered 🔹 Practical, case-based approaches to risk stratification and clinical decision-making ➡️Gain valuable insights into this rapidly advancing area of hereditary GI cancer care. 🔬💡 📍CGA-IGC members, check your inbox for registration details. Not a member? Join at cgaigc.com #HereditaryCancer #PancreaticCancer #CancerSurveillance #CancerGenetics #Gastroenterology #HereditaryGICancer #MedicalEducation
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Aatur Singhi, MD PhD retweeted
All of the negative comments about daraxonrasib center around how it’s not a “cure” for pancreatic cancer. For the longest time, we’ve dealt with a substandard therapy-chemotherapy; and watched our patients succumb to this awful disease. On RASolute302- not only did patients live longer and tolerate the therapy better than 2L chemo- they were also more likely to receive subsequent line therapy. That is indeed something to celebrate. Most importantly- this isn’t THE cure we’ve been looking for but this is certainly the dawn of a new era that we’ve all been anticipating for so long. Every therapy has AEs and will need fine tuning and real world experience before it becomes more tolerable for the not-so-fit patients in clinic. Drug pricing is also not an issue unique to this drug-it is a systemic issue that needs addressing on multiple levels. It’s so easy to be an “expert critic” for likes and engagement on social media and so hard to work towards moving the needle forward for patients.
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Aatur Singhi, MD PhD retweeted
New paper from @BiffiGiulia in @NatureCellBio comparing fibroblast diversity and epithelial–stromal interactions between #pancreatitis and #PancreaticCancer using a plethora of sample types across species. Congratulations Giulia! nature.com/articles/s41556-0…
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Aatur Singhi, MD PhD retweeted
Preprint on @10xGenomics Atera single cell whole transcriptome analyses (WTA) platform biorxiv.org/content/10.64898… One demonstrated advantage is single cell resolution inferred CNV that can be mapped with co-occurring tumor microenvironmental alterations. Great for precursor lesions.
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Pancreatic cancer is notoriously hard to treat, but we are making progress. Recent @theNCI -funded work that sheds light on mechanisms behind #daraxonrasib resistance and could help clinicians choose treatment combos that outsmart pancreatic tumors. go.nih.gov/AcvCu95
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Dr. Janie Zheng explains her hospital’s protocol for making sure all new pancreatic cancer patients get genetic testing. bit.ly/4jqRPKx
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Some hepatic adenomas are easy - this one is beta catenin activated and thus should be resected. An endothelial cell (negative internal control, arrow) shows no nuclear staining. Note the unpaired artery. However, Mod Pathol offers some tips! pubmed.ncbi.nlm.nih.gov/3716…
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Aatur Singhi, MD PhD retweeted
ESMO Clinical Practice Guideline Express Update on daraxonrasib in the treatment of metastatic pancreatic cancer @Annals_Oncology doi.org/10.1016/j.annonc.202… 👉pan-RAS(ON) inhibitor daraxonrasib included in second-line therapy @myESMO
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Unexpected opening! Surgical Pathology Fellowship at @UPMCPathology / University of Pittsburgh for AY 2027–2028. 9 months of core surgical pathology (~50,000 specimens/year), plus tailored electives and department-funded research. 📧 [email protected] | [email protected]
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Aatur Singhi, MD PhD retweeted
The future of biomedical research depends on sharing high-quality data. The NIH S-index aims to recognize and reward researchers whose shared datasets drive new discoveries and advance science beyond publications alone. Congratulations to the winners of the NIH S-index Challenge, whose innovative approaches are helping shape this new metric for data sharing! Learn more about the winning teams: bit.ly/46bLLiZ.
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Aatur Singhi, MD PhD retweeted
Are you interested in knowing the outcomes of the different subgroups participating in the NETTER-2 trial of PRRT with Lu-177 DOTATATE vs. octreotide LAR? If so, wait no longer. It is available online now. In short, PRRT is effective in this population. -- PFS in G2: 29 months -- PFS in G3: 22.2 months -- PFS in pNETs: 19.4 months -- PFS in sbNETs: Not reached Response rates are quite high: -- G2: 40.4% -- G3: 48.1% -- pNETs: 51.2% -- GI/sbNETs: 33.3% More details below... thelancet.com/journals/eclin…
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Aatur Singhi, MD PhD retweeted
Important changes coming to how @NIH reports scores on reviewed grants - while individual reviewers will still provide an overall impact score, the investigators will only receive information on which of three broader categories their grant falls under: grants.nih.gov/grants/guide/…
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Aatur Singhi, MD PhD retweeted
From RAS inhibitor resistance to rational combination strategies nature.com/articles/s41591-0… Thanks @graokane @MacarullaTeresa et al for the editorial accompanying today's @NatureMedicine paper on mechanisms of resistance to Daraxonrasib in #PancreaticCancer nature.com/articles/s41591-0…
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Aatur Singhi, MD PhD retweeted
Cholangioblastic cholangiocarcinomas are really interesting - I am old so I like the old name! Hissong E, et al. NIPBL::NACC1 Fusion Hepatic Carcinoma. Am J Surg Pathol. 2024 Feb 1;48(2):183-193. PMID: 38047392; PMCID: PMC11238093.
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Aatur Singhi, MD PhD retweeted
Neural niches are recurrent features of human cancer that may relay signals to nearby cells, to the immune system, + to the brain. So what’s in these niches, and what happens when cancer cells barge in? We take a look under the hood in our new preprint 1/ biorxiv.org/content/10.64898…
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