Our lab at the University of Maryland studies vector-borne diseases, with a special focus on Lyme disease and novel prevention & treatments. *Views are our own*
College Park, MD
Joined September 2020
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We are proud to share this article from our group, published in @NatureGenet, about the elusive genome of the black-legged or deer tick, featuring our presentation of the most complete genome, transcriptome, proteome, and related analysis for the species! nature.com/articles/s41588-0…
IL36γ signaling promotes mammalian anti-tick immunity | PNAS pnas.org/doi/10.1073/pnas.26…
A nice spotlight in @TrendsParasitol by @jutraslab and colleagues - thanks for bringing attention to this fascinating pathway!
Drs @Ebohon_1 Brittany Hart & Brandon Jutras highlight @PalLabUMD & colleagues’ @ScienceMagazine paper on Dome1–JAK–STAT signaling between #tick and mammalian host. @vtbiochem @FralinLifeSci @virginia_tech @VaMdVetMed
authors.elsevier.com/a/1gnlp…
Utpal Pal Lab retweeted
Parasitic ticks exploit host-derived interferon-γ through cross-species signaling to promote arthropod immunity and development, according to a new study in Science. scim.ag/1cb
Utpal Pal Lab retweeted
🎉 OUT TODAY @NatureGenet
📰 A high-quality Ixodes scapularis genome advances tick science
👩🏿🤝👨🏼 @DeSandipDe @PalLabUMD and team
👇🏼
go.nature.com/3D0Psdv
Utpal Pal Lab retweeted
CIC bioGUNE @brta_eus researchers describe the presence of a tick #molecular receptor able to respond to signals from the host.
🔗 ow.ly/ZMNe50MoK75
@Ikerbasque @PalLabUMD @UMNews @Yale @MAGEUMD @NIH
#research #science
Excited to share our discovery of a new twist in host-pathogen interactions, published today in @ScienceMagazine! science.org/doi/10.1126/scie…
Who doesn't love a striking immunofluorescence image? We're very proud that one of our tick images was selected by the editor of @TrendsImmuno for the cover of their current issue! cell.com/trends/immunology/i…
We are thrilled to announce the publication of a featured review from our lab. Check out our article in @TrendsImmuno which highlights some truly fascinating aspects of tick-host associations.
Tick host immunity: vector immunomodulation and acquired tick resistance dlvr.it/S0hSHM #immunology
Our lab is hiring a new postdoc to work on drug discovery and vaccine projects. If you (or someone you know) is interested in this exciting work, please see this link for more information! nature.com/naturecareers/job…
We are very excited that @CellMicrobiol is featuring our new article about tick biology & Lyme disease as the Editor’s Choice Article, and with a really cool image of the tick gut on the cover! onlinelibrary.wiley.com/doi/…
Some surprising new statistics about Lyme disease from @CDCgov: Now there's an estimate of close to 500,000 new cases annually, in the US alone - much more than we thought before. Here's to hoping that our research can make a difference! wwwnc.cdc.gov/eid/article/27…
As biologists, we care deeply for all living things, and yearn for the wellbeing of species around the world. How refreshing it is to see how people have come together to protect threatened wildlife in their communities! cnn.com/2020/11/17/americas/…
Utpal Pal Lab retweeted
Mice lacking PGLYRP1 had an increased B.b. "spirochete burden in the heart and joints, along with splenomegaly. Mice lacking PGLYRP1 also showed signs of immune dysregulation, including lower serum IgG levels and higher levels of IFNγ, CXCL9, and CXCL10." #LymeDisease
New | A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in #Lyme borreliosis.
via @PLOSPathogens
... dx.plos.org/10.1371/journal.…
Utpal Pal Lab retweeted
EXCELLENT talk by @ImmunoFever on the involvement SIRPa & CD-47 cells in helping Borrelia Burgdorferi's evade the immune system. Must watch! 👇
Ever had to give a talk a few minutes after waking up because you didn't realise how early it was? It happens to the best of us, doesn't it Michal @ImmunoFever? 😂😂
Michal Tal's talk on immune clearance of pathogens is finally online!
youtu.be/8DXjx5-aYSg
Utpal Pal Lab retweeted
Very excited to share our preprint describing a CRISPRi platform for Borrelia burgdorferi. Project led by @NickTakacs86 in fun collaboration with lab members, @JunLiuLab and Patti Rosa. #LymeDisease #Lyme biorxiv.org/content/10.1101/…
Check out our new paper in @CellMicrobiol, where we investigate an important structure (and related protein) in the tick gut. The results of our study show some promising results that can hopefully be applied to novel Lyme disease interventions.
Recently published in Cellular Microbiology by Yang, Koči and Smith et al. A novel tick gut protein promotes #Borrelia burgdorferi infectivity and impacts the resident #microbiome @PalLabUMD #Ticks #LymeDisease
Check it out here: onlinelibrary.wiley.com/doi/…
DNA is the blueprint of life - but environmental factors can affect how DNA is differentially expressed within individuals! Our new review from @TrendsGenetics delves into the concept of epigenetics as it relates to ticks, vector biology, & Lyme disease: cell.com/trends/genetics/ful…