The Pain and Addiction Interaction Neurosciences (PAIN) Lab @YalePsych seeks to develop new approaches for understanding & treating chronic pain and addiction

New Haven, CT
Joined August 2024
Does #cannabis co-use make quitting #tobacco harder? Our new meta-analysis of 18 studies (N=229K) found 25% lower odds of tobacco cessation among people who use cannabis. But targeted modulation of the endocannabinoid system may be a different story. Now in Neuroscience & Biobehavioral Reviews: doi.org/10.1016/j.neubiorev.…
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Inspired from The Real World of Addiction Specialty Track at #CPDD26 - DAD is seeking papers for a special issue focused on designing translational addiction science that better reflects patients, real-world settings, and meaningful outcomes. cpdd.org/call-for-papers-des…
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Excited to speak with stellar colleagues at the #USASP2026 Annual Scientific Meeting (March 23–26, Philadelphia)! Join us! In Person: usasp.memberclicks.net/usasp… Or Virtually: usasp.memberclicks.net/virtu… Looking forward to a great discussion at the #pain–#addiction interface.
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New paper out in Molecular Psychiatry! Huge congratulations to first author @Gabriel_PACosta for leading this #translational systematic review & meta-analysis on #endocannabinoid modulation in #alcohol use disorder. Proud of this team effort. nature.com/articles/s41380-0…
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Pleased to share this recent @IASPpain Journal Club featuring our @RAPMOnline systematic review and meta-analysis on buprenorphine versus full agonist #opioids for acute postoperative #pain management. Watch here: youtube.com/watch?v=80nrmwTi…
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Is once-daily #methadone enough to manage #pain among patients with #OUD? Using quantitative sensory testing (#QST), we show evidence of greater pain sensitivity just before the next methadone dose—suggesting an inter-dose “hyperalgesic window.” tinyurl.com/4thjjx8m
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🚨New in @npp_journal: We used an opioid-withholding human lab model to ask not just whether #CBD affects pain, but when—across the #methadone dosing cycle in people with co-occurring #OUD + chronic #pain. Effects were dose- and phase-dependent. shorturl.at/NqLrj
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Glad to have joined the @ASAMorg Beyond the Abstract #podcast to discuss our paper in the Journal of Addiction Medicine. Among patients on #methadone, greater childhood trauma tracked with worse #pain, more #alcohol use, and earlier #cannabis initiation. podcasts.apple.com/us/podcas… @YaleADM @YalePsych @USASP_SubUseSIG
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Thrilled to see our @PainLaboratory postdoc @Gabriel_PACosta selected for the 2027 @ACNPorg Near-Peer Mentorship Program! Very well deserved, and I’m excited to continue supporting your growth and all that lies ahead. Congratulations!
Incredibly honored to share that I've been selected as a Mentee for the 2027 ACNP Near-Peer Mentorship Program! Grateful to the @ACNPorg for the opportunity, and to my mentor @JPDeAquinoMD for the continued support and for encouraging me to apply! @YalePsych @YaleADM
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New R01 from NIAAA! The @PainLaboratory will build a human laboratory model of how #alcohol shapes pain in co-occurring AUD and chronic #pain. Alcohol dulls pain as blood levels rise; pain rebounds as they fall — a cycle that may drive drinking. This study advances a platform to test novel treatments for both.
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New NCCIH R61/R33! The @PainLaboratory will test if #psilocybin helps people with chronic low back #pain benefit more from physical therapy. When pain signals danger, movement is avoided. We'll study whether psilocybin shifts that. Grateful to @GaylordHealth and to our team!
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