PRotocolised Evaluation of permiSSive blood pressure targets versus Usual caRE. A multi-centre randomised controlled trial for critically-ill children. #PedsICU
Joined July 2022
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PRESSURE study retweeted
🧵 Presented at #WFPICCS26: Among critically ill children with hypotension receiving invasive ventilation and vasoactive drugs, a permissive #BloodPressure target of the fifth percentile for age did not significantly change the composite outcome of mortality and duration of invasive ventilation at 30 days vs usual care.
The permissive target was associated with lower exposure to vasoactive drugs without a signal for harm.
ja.ma/4rBWwVH
#WFPICCS26 @WFPICCS
PRESSURE study retweeted
Day 2 at #WFPICCS2026! Today’s late-breaking session spotlighted results from the PRESSURE Trial, what they could mean for practice, and an exciting look at the upcoming PICNIC Trial. Thank you to David Inwald, Luregn Schlapbach, @PaulMouncey, sites, families, and all involved!
PRESSURE study retweeted
Great first day at #WFPICCS2026 - learning about progress across PICU-CONNECT, ANZICS CORE and discussing @PIVOTALTrial. We’re looking forward to two more days of collaboration to improve critical care for children and families. Thank you @anzics, @WFPICCS, and all involved!
What a fantastic weekend with 8 randomisations into the PRESSURE study! Well done to all site teams for their ongoing hard work and commitment! A special shout out to @stmaryspicu for randomising 3 of these patients over the weekend! Let's keep this momentum going! 🙌
🎉Exciting milestone! We've now recruited over 1,200 patients to the PRESSURE study! Thank you to the incredible hard work & dedication of all site teams for helping us reach this milestone! A special well done to Addenbrooke's hospital for randomising the 1,200th patient!
We are very excited to announce that over 1000 patients have been recruited to the PRESSURE study! Thank you so much to all sites and retrieval teams for getting us to this fantastic milestone. Well done to @Leeds_Childrens for randomising the 1000th patient!
Over 950 patients have now been recruited to the PRESSURE study! A massive thank you to all sites and retrieval teams for getting us to the halfway point, and especially to @UHS_PICResearch for randomising the 950th patient!
Over 900 patients have now been recruited to the PRESSURE study! A massive thank you to all sites and retrieval teams, and especially to @BristolPicu for randomising the 900th patient!
800 patients have now been recruited to the PRESSURE study! A massive thank you to all teams and especially to @GreatNorthCH for getting us to this milestone.
And that’s it!
Thank you to everyone who attended our Investigator’s Meeting today!
It’s been wonderful to hear from you all. We’re really looking forward to implementing all the ideas, tips and tricks that we heard ☺️
@Dlawni @ICNARC @NIHRresearch
#criticalcare #PICU
Kicking off our sharing sessions with a really interesting presentation on insights from the 65 Trial by @PaulMouncey, followed by some group work.
There’s so much to learn from each other! Teamwork really does make the dream work 😌
@ICNARC @NIHRresearch
#PICU #criticalcare
Our joint Investigator’s Meeting with @GASTRIC_PICU has been off to a great start so far!
We had some great discussions this morning and we’re so excited to learn more from each other in our PRESSURE session this afternoon ☺️
@Dlawni @ICNARC @NIHRresearch
PRESSURE study retweeted
We’re so excited to welcome everyone to today’s investigators meeting @etcvenues!
Looking forward to morning of interesting discussions and sharing ideas, tips and tricks ☺️
@lyvonnetume @pus27 @ICNARC @NIHRresearch
PRESSURE study retweeted
📢 Calling all critical care nurses and matrons! Your insights matter.
ICNARC has joined forces with the SEISMIC-R study team at the @UniofHerts, led by @drnatpat, for an important survey on ICU nurse staffing. 1/6
#CriticalCare #Nursing
700 patients have now been recruited to the PRESSURE study! A massive thank you to all teams and especially to @BristolPicu for getting us to this milestone.
A huge well done to the team at
@cuh_picu for randomising the 650th patient to the PRESSURE study!
Welcome to the last two centres to join the PRESSURE study @nottmchildrens and @PICU_Scot - and thank you to their research teams for working so hard to set up - both have now randomised their first patients!
600 patients have now been recruited! A massive thank you to all teams and especially to
@GreatOrmondSt #PedsICU for getting us to this milestone.
