Research scientist, Immunology

New York, NY
Joined August 2012
Three young American Barn Owl siblings pose for their family portrait on Thursday night. Most seem able to take short flights around the Upper West Side water tank where they have been growing up. 🦉 🦉 🧡 🦉
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A glimpse of one of the Central Park Coyotes, as the Canadian Geese file by. Central Park, New York City #birdcpp #centralpark
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The Barred Owl, now present in Central Park for two weeks, perches by the Loch. 🦉 🧡
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Just spotted the Tesla Cybercab driving down 1st Ave in Manhattan. 👀🚕 @Tesla @robotaxi @TeslaNewswire @RobotaxiRadar
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There are no child prodigies in biology for the same reason there’s none in mining or agriculture. Biology is an experimental science and is labor-bottlenecked, not intelligence-bottlenecked.
Why are there no child prodigies in biology? This question seems to me to reveal something important about the nature of biological knowledge It has new relevance as try to distinguish questions that can be answered with pure intelligence from those that require large datasets
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Fun fact, every particularly nice place in NYC is only nice because it's managed and funded by private organizations (rich people). This includes central park, bryant park, prospect Park, the high line, Brooklyn bridge Park, West side highway, etc.
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Microglia feet are highly dynamic and can be in contact with dense networks of axons. In this video by our #ElectronMicroscopy team using MICrONS data, a microglia (purple) contacts with an excitatory pyramidal neuron (gold). Slowly the axons under the feet are revealed.
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Three chicks in the Red-tailed Hawk nest on Central Park South near Seventh Avenue.
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TREM2+ macrophages have rapidly emerged as key regulators in diseases. Studying them requires specific antibodies. Among 14 tested antibodies in KO cell lines, 5 are specific in WB. Pick up the right one. Full report: tinyurl.com/TREM2Ab Or here: tinyurl.com/OGA-TREM2
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Journalism demands fact checking, disclosure, and due diligence. What @NickKristof and his editors gave @nytimes readers was an uncritical amplification of unverified claims, outlandish accusations, and untrustworthy sources. The question is no longer just whether al Sai's story is credible. It’s how the @nytimes published a piece of this magnitude, based on a source with this background, without disclosing any of it to readers. That is the story.
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Moonlight—or the lack thereof—affects the energy and foraging of nocturnal organisms like the red-necked nightjar, a monthly cycle that shapes the timing of key life events like migration and reproduction. scim.ag/4uiVbTQ @ebdonana @HedenstrmAnders
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While the non-disclosure of the conflicts of interest is a serious issue, it is also important to point out that @addictedtoigno1 and others found several instances of image duplication in this paper. pubpeer.com/publications/64D…
There is a tendency to minimise the implications of the recent retraction in PNAS of the Mariano Barbacid paper for non-declaring their conflicts of interest. This is not a minor procedural oversight. It touches a core structural principle of modern scientific practice: transparency as a prerequisite for credibility. Conflict-of-interest disclosure is not a bureaucratic formality. It is a mechanism designed to allow readers, reviewers, and the broader community to interpret data within its full economic and intellectual context. When omitted—particularly in cases where authors hold ownership stakes in companies positioned to commercially exploit the reported findings—the omission distorts the epistemic framework in which the results are evaluated. We have precedent. Both in Spain and the United States, high-profile cases have demonstrated the institutional consequences of such failures. A prominent clinician-scientist—former chief in leading hospitals across both countries and president of major international medical societies— resigned from positions in the United States after failing to disclose relevant financial conflicts, subsequently transitioning to the pharmaceutical industry. The issue was not scientific fraud; it was a breach of transparency. Yet the reputational and institutional consequences were substantial. There is an additional layer here that is often overlooked. The publication in question was submitted under the “contributed” track available to members of the United States National Academy of Sciences. This pathway—effectively a form of editorial privilege—allows for an expedited and, in practice, more controlled review process. It is a mechanism unavailable to the majority of researchers, who must navigate standard peer review with no such structural advantage. This episode is not about a single paper. It reflects a tension between scientific authority and scientific accountability. Prestige may facilitate access, but it does not exempt one from the foundational norms that sustain trust in the system.
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PL Loyher retweeted
Replying to @AlvaroCurielGa1
The retraction is a massive red flag. If you can’t be transparent about your financial stakes in a biotech company (Vega oncotarget) you shouldn’t be trusted to lead a clinical trial. That 4 millions raised from the public could have funded dozens of other brillant scientists.
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Huang et al report on somatic mutations in AD microglia using a massive cohort which allowed identification of new variants 👀. It builds on the foundation laid by Vicario et al. in both eLife and Neuron ('24), who first identified the enrichment of these microglial clones.
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I like this raccoon’s vibe. 🦝 #urbanwildlife #centralpark
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Excited to share- Building on our work defining TRMacs heterogeneity, we show that distinct chemokine+ IM subsets and recruited TAM niches shape pro- and anti-tumor immunity within to the TME, while Ag+ moDCs trafficking to LNs dampen DC-based neoAg vac nature.com/articles/s41590-0…
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PL Loyher retweeted
the weather is pretty bad inside a mouse brain
Optical clearing & time-lapse fluorescent imaging of Live mouse Brain (up to 800 μm of depth)🤯 SeeDB-Live is finally in peer-reviewed print (1.5 yr from Preprint)🥸 An acute olfactory bulb slice(P11) loaded with GCaMP6f (Ca2+ sensor) was imaged with #2PM at a depth of 150 μm during clearing with SeeDB-Live👹 @Shigenori774 @TakeshiImaiLab @naturemethods 2026 nature.com/articles/s41592-0…
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The Empire State Building casts a shadow as the sun rises behind the skyline of midtown Manhattan in New York City, Tuesday morning #newyork #newyorkcity #nyc @EmpireStateBldg #sunrise
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To any future historians reading this, this era will make a lot more sense if you remember that every name is the opposite of what it really is. The antifascists are fascists, the antiracists are racists, the fact-checkers are propagandists, etc. Hopefully this has been fixed by your time.
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new spinosaurus
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