Prostate oncologist, cyclist, would-be climate activist

UK
Joined January 2016
Chris Parker retweeted
Our #ZZFIRST trial is out today in @NatureMedicine! An academic randomized phase II trial of Talazoparib + Enzalutamide in high-volume mHNPC integrating spatial transcriptomics on longitudinal tumor biopsies. Thanks to all patients and funding from DoD/CDMRP + @ContraCancerEs
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New in #practicalRO: Androgen Deprivation Therapy (ADT) and Radiotherapy (RT) with Imaging Evaluation Longitudinally (ARIEL) Trial: Protocol, Early Results, and Implications of Neoadjuvant ADT for Focal RT Boost in Prostate Cancer. This article was presented during #ASTRO2026 in Quick Pitch Session 22.
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8️⃣ end 🙏🏼Patients who got in the 🧲 tube for research 🙏🏼Physicians who enrolled patients 🙏🏼Research team for consenting and collecting data 🙏🏼@ASTRO_org @PCF_Science for funding the trial
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Chris Parker retweeted
An essay worth reading, for every clinician and patient (with a PrCa paragraph) The Quiet Half of Good Medicine jamanetwork.com/journals/jam…
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Chris Parker retweeted
A day in the life of a @NHSEngland palliative medicine consultant @JoeHawk75825077 blogs.bmj.com/spcare/2026/01…
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Chris Parker retweeted
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Replying to @LukeTryl
As someone who regards themselves as a socially progressive, pro-human rights, liberal, atheist, NHS palliative care doctor, I want to challenge your framing of AD as “socially progressive”, Luke. Freedom to choose state assistance in ending your life has to be balanced against ensuring vulnerable people are not coerced into ending their lives prematurely by AD - whether this is due to subtle societal messages that your life has no value, or lack of the basic palliative & social care that might make your life still worth living, or pressure from self-interested individuals. How is protecting the vulnerable the opposite of “socially progressive”? How is the elevation of personal freedom above other values synonymous with “socially progressive”? There’s a reason so many medical bodies & those representing disabled people opposed this bill - and it’s not social conservatism, it’s concern for vulnerable people. (I see more death & dying than almost anyone & I happen to be pro AD, btw, provided a legal change is safe. This bill was very far from that.)
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PFS endpt treats different events as equivalent, but how well do oligomet RT trials tell us what us what actually constituted progression? In this study led by Cole Friedes, we found across 21 RCTs, event-level reporting was limited...🧵1/2 @OncoAlert thegreenjournal.com/article/…
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…only 24% specified the 1st PFS event, & clinically relevant consequences were rarely reported. Rather than abandoning PFS, we propose a simple 5-item reporting rubric to deconstruct it into clinically meaningful events. Take a read & congrats to Cole! 2/2
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⚠️ 🌍 ⚠️ We stand with humanity: A scientist statement to confront climate destruction⚠️ 🌍 ⚠️ ✒️ 🙏 If you are an academic or healthcare professional, please consider signing. 🙏✒️ framaforms.org/we-stand-with…
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Very nice editorial by @TylerSbrt Radiotherapy dose intensification for high-risk prostate cancer—what is gained? - The Lancet Oncology thelancet.com/journals/lanon…
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Chris Parker retweeted
Proud of our multi-D editorial in @JAMA_current with my incredible urologic oncology collegues @jeshoag @SBasourakos We relate the classic tale of the Emperor's New Clothes with the problematic and promising practice patterns we observe in prostate cancer cancer. @AmerUrological @ASTRO_org @ASCO @DrChoueiri @urotoday @PCF_Science @qdtrinh @Adam_Weiner535 @wandering_gu @uroegg @DrHowardSandler @jmmrad @HimanshuNagarMD @ndesai2005 @piet_ost @alison_tree @nytimes @NCCN @NRGonc @rtdess
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📝🚨 - New paper on detection and localization of unfavorable-histology #ProstateCancer (uhPC: GG3+ or cribriform/IDC GG2) MRI🧲 compared to biopsy and RP histopath authors.elsevier.com/sd/arti… @EurUrolOncol @OncoAlert @UroToday @PCF_Science @APCCC_Lugano @UCSDCancer 🧵1️⃣
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Chris Parker retweeted
Caroline Lucas, Chris Packham, George Monbiot and others are asking you to add your signature to a petition, putting pressure on the government to hold a televised emergency briefing on the risks of climate and nature breakdown. They need 100,000 signatures. petition.parliament.uk/petit…
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🚨 177Lu-PSMA-617 to ADT + ARPI improves rPFS (PSMAddition) 🚨 @TheLancet 👥 1144 pts w/ PSMA+ metastatic APMN/S #ProstateCancer (50% de novo, 68% high-volume) 📊 Phase 3 RCT, 1:1, open-label, 169 sites, crossover allowed at progression 💊 177Lu-PSMA-617 (7.4 GBq q6w x6) + ADT/ARPI vs ADT/ARPI ⏱️ Median f/u 19.6 mo for rPFS ✅ rPFS HR 0.72 (95% CI 0.58-0.90), p=0.0021; median not reached in either arm BUT👇 ⚠️ G3+ AEs 51% vs 43%; dry mouth 46% vs 4% (all G1-2); more cytopenias and GI events ⚠️ QoL trended worse w/ RLT: time to FACT-P worsening 11.3 vs 17.1 mo (HR 1.14, CI crosses 1); gap seen mainly during treatment cycles, similar arms after week 36 🎯 RLT moves into earlier stage PCa. But we need to keep an eye on QoL @AmerUrological @UroOnc @SUO_YUO @PCFnews @urotoday @UrologyTimes @PCF_Science 🔗shorturl.at/yGNAS
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