@OttoLab

Systems Chemistry Group at the University of Groningen. Transition of chemistry to biology (incl. origins of life, synthetic life), complex systems.

 Groningen, The Netherlands
otto-lab.com
Joined February 2013
  • Tweets339
  • Following477
  • Followers2.7K
55Media
Selection for photocatalytic function through Darwinian evolution of synthetic self-replicators bit.ly/4oCH7C1
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How to select primitive / synthetic replicators based their photocatalysis? Check out our manuscript just published in @NatureCatalysis : nature.com/articles/s41929-0… @KaiLiu125348 @Ottolab #OoL #Origins #Prebiotic #Evolution
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SijbrenOttoLab retweeted
J. Am. Chem. Soc.@J_A_C_S
28 Nov 2024
Light-Mediated Interconversion between a Foldamer and a Self-Replicator | Journal of the American Chemical Society @LMU_Muenchen @StratinghInst @univgroningen #Foldamer #SelfReplicator #LightMediated #Interconversion pubs.acs.org/doi/10.1021/jac…

Light-Mediated Interconversion between a Foldamer and a Self-Replicator

Abstract. Self-replicating molecules and well-defined folded macromolecules are of great significance in the emergence and evolution of life. How they may

pubs.acs.org
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SijbrenOttoLab retweeted
J. Am. Chem. Soc.@J_A_C_S
28 Nov 2024
Simultaneous Formation of a Foldamer and a Self-Replicator by Out-of-Equilibrium Dynamic Covalent Chemistry | JACS @LMU_Muenchen @StratinghInst @univgroningen #Foldamer #SelfReplicator #OutofEquilibrium #Dynamic #Covalent #Chemistry pubs.acs.org/doi/10.1021/jac…

Simultaneous Formation of a Foldamer and a Self-Replicator by Out-of-Equilibrium Dynamic Covalent...

Abstract. Systems chemistry has emerged as a useful paradigm to access structures and phenomena typically exhibited by living systems, including complex mo

pubs.acs.org
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SijbrenOttoLab retweeted
Kai Liu@KaiLiu125348
10 Nov 2024
What can dissipative chemistry bring us? In our recently published paper, we demonstrate the emergence of mechanical function from disspative droplet systems. @NatureChemistry nature.com/articles/s41557-0…

Molecular-scale dissipative chemistry drives the formation of nanoscale assemblies and their...

Nature Chemistry - The use of molecules as fuels to achieve function is largely unexplored. Now it has been shown that fuelled dissipative self-assembly can yield transient droplets that release a...

nature.com
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Probe the non-enzymatic macrocyclization reaction of benzene-1,3-dithiol in the presence of peptide condensates by reactive Martini simulations, reported by @CG_Martini @OttoLab @csbrasnett nature.com/articles/s42004-0…

Capturing chemical reactions inside biomolecular condensates with reactive Martini simulations

Communications Chemistry - Biomolecular condensates show distinct physicochemical properties that may affect the rate of enzymatic activity and control cellular redox reactions, however, their...

nature.com
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A little peak into last year's work with @Juntian74804617 and @Armin__Kiani in @OttoLab . You think our replicators are already complex enough? Then brace yourselves, Marcel has put 2-3 of them in competition and we had to make sense of their behaviour... chemrxiv.org/engage/chemrxiv…

Competitive Exclusion among Self-Replicating Molecules Curtails the Tendency of Chemistry to...

The transition of chemistry into biology is poorly understood. One of the key questions in this transition is how the inherently divergent nature of chemical reactions can be curtailed, allowing...

chemrxiv.org
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Top Science
@isciverse
6 May 2024
This study introduces a new mechanism that decreases error rates and corrects errors in synthetic self-replicating systems driven by self-assembly. @angew_chem #chemistry #Science #chemed #Technology #news @OttoLab @OmerMarkovitch onlinelibrary.wiley.com/doi/…
Angewandte Chemie@angew_chem
1 Mar 2024
Binding of Precursors to Replicator Assemblies Can Improve Replication Fidelity and Mediate Error Correction (Sijbren Otto and co-workers) #openaccess @OttoLab @OmerMarkovitch onlinelibrary.wiley.com/doi/…

Binding of Precursors to Replicator Assemblies Can Improve Replication Fidelity and Mediate Error...

Binding of precursor molecules to the side of a fibrous assembly of self-replicating macrocycles can improve the fidelity of replication and yield a novel error-correction mechanism, provided that...

onlinelibrary.wiley.com
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Generalist versus Specialist Self-Replicators (Sijbren Otto and co-workers) @seilenfranzli @Nitrogeno_N @GuilleMonrealS @OttoLab @StratinghInst onlinelibrary.wiley.com/doi/…

Generalist versus Specialist Self‐Replicators

Whether assembly-driven self-replicators that emerge from a mixture of two building blocks specialize on one resource or are generalists was found to depend on their supramolecular organization.

chemistry-europe.onlinelibrary.wiley.com
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Binding of Precursors to Replicator Assemblies Can Improve Replication Fidelity and Mediate Error Correction (Sijbren Otto and co-workers) #openaccess @OttoLab @OmerMarkovitch onlinelibrary.wiley.com/doi/…

Binding of Precursors to Replicator Assemblies Can Improve Replication Fidelity and Mediate Error...

Binding of precursor molecules to the side of a fibrous assembly of self-replicating macrocycles can improve the fidelity of replication and yield a novel error-correction mechanism, provided that...

onlinelibrary.wiley.com
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Our newest paper is out!!! Here we show how a replicator system can correct errors during replication. Congrats @OmerMarkovitch and @Juntian74804617 🥳 Check it out: onlinelibrary.wiley.com/doi/…
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SijbrenOttoLab retweeted
The Goldup Lab@GoldupLab
22 Dec 2023
Fancy doing some shiny new chemistry in a shiny new building? If so, come and join us @UoBChemistry 😀 We have fully funded PhD positions available working on…
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Sijbren and Kayleigh were interviewed by @NEMOkennislink at the occasion of the 70th birthday of the famous Miller-Urey experiment. Check it out if you speak Dutch - or know how to use Google translate!
This Post is from an account that no longer exists. Learn more
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SijbrenOttoLab retweeted
Babis Pappas@pappas_babis
4 Dec 2023
We have a PhD position on phosphate-driven non-equilibrium assemblies @ERC_Research funded at @FitFreiburg @UniFreiburg. Deadline for application is 15/01/24. More information can be found here: static1.squarespace.com/stat… RT appreciated!
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Can a purely chemical system reduces its #errors during #replication? And even "correct" them?. In this latest @ChemRxiv we are claiming YES to both questions! doi.org/10.26434/chemrxiv-20… @OttoLab @Juntian74804617
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BREAKING💥Ottogroup was awarded an ERC synergy grant, together with @AshkenasyLab and the groups of Eörs Szathmáry and Andrew Griffiths. Greatest thanks to all collaborators, it was a long and winding journey but it paid off!
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More details about the proposal on the university website👇 rug.nl/research/stratingh/ne…

Sijbren Otto awarded an ERC Synergy Grant

Sijbren Otto awarded an ERC Synergy Grant

rug.nl
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More PhD and also post-doc positions will open - especially prospective post-docs are encouraged to get in touch with Sijbren soon. We offer high-quality research in a multidisciplinary field and (soon) in a brand-new building in Groningen!
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Reminder 📢 We have a total of three PhS positions open! Two within a MSCA ITN, more at darchem-dn.eu. Applicants should have been no longer than 12 months in NL ober the last 3 years; deadline 31 oct. One more position on diff. funding is without residence constraints.
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Please spread the word! We look for excellent students with motivation to work in an interdisciplinary environment. Potential candidates should directly get in touch with Sijbren: otto-lab.com
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